Engineering Biosensors: Kinetics and Design Applications

Engineering Biosensors: Kinetics and Design Applications

by Ajit Sadana
     
 

Analysis of the binding between an analyte and a receptor is a key step in the design of immunodiagnostic assays and biosensors. This book describes and makes more quantitative the binding kinetics between an analyte and a receptor using a technique based on fractals. Actual examples from the existing literature are provided to illustrate the simplicity and the

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Overview

Analysis of the binding between an analyte and a receptor is a key step in the design of immunodiagnostic assays and biosensors. This book describes and makes more quantitative the binding kinetics between an analyte and a receptor using a technique based on fractals. Actual examples from the existing literature are provided to illustrate the simplicity and the wide applicability of the technique. A better understanding of the binding interactions on the biosensor surface will greatly assist in the design as well as in the improvement of existing biosensors. In addition, the book deals with the economics of the biosensor market, and its past, present, and future trends.

KEY FEATURES:
· Describes a simple, rapid, and robust technique for evaluating binding kinetics in biosensors
· Includes a large number of examples illustrating the mathematical techniques
· Contains difficult to find data on existing biosensor industry economics
· Provides comprehensive introduction to biosensors, including illustrations to better explain the main concepts
· Includes recommendations to help design and improve existing biosensors
· Supplies useful information for biologists, chemists, and mathematicians
· Draws a distinction between classical modeling techniques and fractal models

The techniques described will provide chemists, biologists, and mathematicians with an alternative technique for better modeling and describing complex analyte-receptor binding kinetics. This book should help those in the biosensor industry to better understand the existing market and to predict where the market is heading.

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Product Details

ISBN-13:
9780126137637
Publisher:
Elsevier Science
Publication date:
09/01/2001
Pages:
420
Product dimensions:
1.06(w) x 6.00(h) x 9.00(d)

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Table of Contents

Preface
1Introduction
2Influence of Diffusional Limitations and Reaction Order On Antigen - Antibody Binding Kinetics
3Influence of Diffusional Limitations and Lateral Interactions on Antigen-Antibody Binding Kinetics
4Fractal Reaction Kinetics
5Influence of Different Parameters on Fractal Dimension Values During the Binding Phase
6Fractal Dimension and the Binding Rate Coefficient
7Fractal Dimension and the Dissociation Rate Coefficient
8Influence of Nonspecific Binding on the Rate and Amount of Specific Binding: a classical analysis
9Influence of Nonspecific Binding on the Rate and Amount of Specific Binding: a fractal analysis
10Fractal Dimension and Hybridization
11Fractal Dimension and Analyte-Receptor Binding in Cells
12Surface Plasmon Resonance Biosensors
13Economics and Market for Biosensors
Index

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