Engineering Biosensors: Kinetics and Design Applications

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Analysis of the binding between an analyte and a receptor is a key step in the design of immunodiagnostic assays and biosensors. This book describes and makes more quantitative the binding kinetics between an analyte and a receptor using a technique based on fractals. Actual examples from the existing literature are provided to illustrate the simplicity and the wide applicability of the technique. A better understanding of the binding interactions on the biosensor surface will greatly assist in the design as well as in the improvement of existing biosensors. In addition, the book deals with the economics of the biosensor market, and its past, present, and future trends.

· Describes a simple, rapid, and robust technique for evaluating binding kinetics in biosensors
· Includes a large number of examples illustrating the mathematical techniques
· Contains difficult to find data on existing biosensor industry economics
· Provides comprehensive introduction to biosensors, including illustrations to better explain the main concepts
· Includes recommendations to help design and improve existing biosensors
· Supplies useful information for biologists, chemists, and mathematicians
· Draws a distinction between classical modeling techniques and fractal models

The techniques described will provide chemists, biologists, and mathematicians with an alternative technique for better modeling and describing complex analyte-receptor binding kinetics. This book should help those in the biosensor industry to better understand the existing market and to predict where the market is heading.

Audience: Senior undergraduate and graduate students in biochemical engineering. Chemists, biochemists, environmental analytical chemists, immunologists, and biochemical engineers in academia and industry. Instrument manufacturers in the healthcare industry.

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Product Details

  • ISBN-13: 9780126137637
  • Publisher: Elsevier Science
  • Publication date: 9/1/2001
  • Pages: 420
  • Product dimensions: 1.06 (w) x 6.00 (h) x 9.00 (d)

Table of Contents

1 Introduction
2 Influence of Diffusional Limitations and Reaction Order On Antigen - Antibody Binding Kinetics
3 Influence of Diffusional Limitations and Lateral Interactions on Antigen-Antibody Binding Kinetics
4 Fractal Reaction Kinetics
5 Influence of Different Parameters on Fractal Dimension Values During the Binding Phase
6 Fractal Dimension and the Binding Rate Coefficient
7 Fractal Dimension and the Dissociation Rate Coefficient
8 Influence of Nonspecific Binding on the Rate and Amount of Specific Binding: a classical analysis
9 Influence of Nonspecific Binding on the Rate and Amount of Specific Binding: a fractal analysis
10 Fractal Dimension and Hybridization
11 Fractal Dimension and Analyte-Receptor Binding in Cells
12 Surface Plasmon Resonance Biosensors
13 Economics and Market for Biosensors
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