Engineering of Functional Skeletal Tissues / Edition 1

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This is the 3rd in a series of reviews, centered on a single major topic of bone replacement (vol. 1 Bone Formation, vol. 2 Bone Resorption) written by acknowledged authorities in the field. The biology of stem cells and cell signals, knowledge needed to make stem cell engineered, bone tissue a reality and how to prevent bone allograft infection is discussed. Furthermore, non-degradable and biodegradable scaffolds, necessary implants to attract bone cells and build suitable bone replacements follow. Other topics are motion and bone degeneration analysis and effect of mechanical factors on bone healing, implants and their role in reparative dentistry and the application of computational modeling to prosthesis design. This text will interest bioengineers, orthopedists, reconstructive surgeons, dentists, physiotherapists and all working in the fields of skeletal and dental tissue engineering and rehabilitation, as well as basic bone scientists interested in translational research.

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Editorial Reviews

Doody's Review Service
Reviewer: Mark R Hutchinson, MD (University of Illinois at Chicago College of Medicine)
Description: This volume in a series on bone biology is dedicated to the engineering of functional skeletal tissues, covering issues regarding inducing the body's cells to accomplish repair, the ability of the skeletal structures to resorb temporary fixation devices, and its ability to attract and stimulate bone formation. This is a highly technical volume most appropriate for the PhD scientist in this field.
Purpose: The authors feel that this book will play a role as functional engineering of bone tissue is ready to play a growing role in orthopedic and orthodontic practice. The book brings readers up-to-date on the current state-of-the-art and concepts regarding the engineering of skeletal tissues.
Audience: This book is likely over the head of the average orthopedic resident, medical student, or even average orthopedic surgeon, and is best focused on the orthopedic scientist who currently is involved in orthopedic research on the engineering of functional skeletal tissues. The authors are PhD scientists who are experts in their fields.
Features: Each chapter is dedicated to a different facet of the engineering of skeletal tissues ranging from stem cells and osteogenic growth factors to biodegradable implants and implantable scaffolds. The 160 pages are packed with scientific information and current concepts and ideas regarding engineering and the effect of scaffolds on skeletal tissue regeneration.
Assessment: This is a high quality book that would be of benefit to PhD researchers and students participating or interested in skeletal tissue research.
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Product Details

  • ISBN-13: 9781852339623
  • Publisher: Springer London
  • Publication date: 12/6/2006
  • Series: Topics in Bone Biology Series, #3
  • Edition description: 2007
  • Edition number: 1
  • Pages: 178
  • Product dimensions: 7.25 (w) x 10.05 (h) x 0.60 (d)

Table of Contents

Stem Cells and the Art of Mesenchymal Maintenance.- Osteogenic Growth Factors and Cytokines and Their Role in Bone Repair.- Bone Allograft Safety and Performance.- Biodegradable Orthopedic Implants.- Titanium Fiber Mesh: A Nondegradable Scaffold Material.- Engineering Polymeric Scaffolds for Bone Grafts.- Injectable Scaffolds for Bone and Cartilage Regeneration.- Motion and Bone Regeneration.- Dental Applications of Bone Biology.- Multiscale Computational Engineering of Bones: State-of-the-Art Insights for the Future.

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