Environmental Stressors in Health and Disease / Edition 1

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Overview

This volume illustrates the impact of environmental oxidants on the tissues of the eyes, lungs and skin, as well as on the immune system - highlighting common illnesses, injuries and pathologies induced by pro-oxidant environmental xenobiotics such as inflammation, immune response, signal transduction, regulation of gene expression, and carcinogenesis. It provides clinical presentations and discusses the effects of environmental oxidants on target organs.

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Product Details

  • ISBN-13: 9780824705305
  • Publisher: CRC Press
  • Publication date: 7/28/2001
  • Series: Oxidative Stress and Disease Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 520
  • Product dimensions: 6.25 (w) x 9.25 (h) x 1.00 (d)

Table of Contents

Series Introduction
Preface
Contributors
I Molecular and Cellular Aspects of Prooxidant Environmental Xenobiotics
1 Free Radical Reactions in Human Disease 1
2 Radicals and Inflammation: Mediators and Modulators 17
3 Autoimmunity Caused by Oxidizing Foreign Compounds 53
4 Role of Oxidative Stress in Chemical Carcinogenesis 81
5 Proposed Mechanisms of Arsenic Toxicity Carcinogenesis 103
6 Redox Regulation of Gene Expression and Transcription Factors in Response to Environmental Oxidants 115
II Target Organs of Environmental Oxidants: Lung
7 Cigarette Smoking and Pulmonary Oxidative Damage 135
8 Health Effects of Diesel Exhaust and Diesel Exhaust Particles 157
9 The Role of Free Radicals in Asbestos- and Silica-Induced Fibrotic Lung Diseases 185
10 Reactive Oxygen Species and Silica-Induced Carcinogenesis 203
11 Atmospheric Oxidants and Respiratory Tract Surfaces 225
III Target Organs of Environmental Oxidants: Skin
12 Redox Modulation and Oxidative Stress in Dermatotoxicology 237
13 Dermatotoxicology of Environmental and Occupational Chemical Hazards: Agents and Action 271
14 Photooxidative Stress in Skin and Regulation of Gene Expression 319
15 Ozone Stress in the Skin Barrier 335
16 Immunotoxicity in Environmental Agents in the Skin 345
IV Target Organs of Environmental Oxidants: Eye
17 Environmental Stressors and the Eye 365
18 Free Radicals and Aging of Anterior Segment Tissues of the Eye 381
19 The Role of Ocular Free Radicals in Age-Related Macular Degeneration 423
20 Nutritional Influences on Risk for Cataract 457
Index 489
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