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Presents the latest research and applications for a new, promising approach to fighting infectious diseases
Enzybiotics is a promising way of fighting bacterial or fungal infectious diseases by using viruses or viral-derived lysins. Drawing from the fields of medicinal chemistry, microbiology, genetics, and biochemistry, this book presents the state of the science in enzybiotics research, fully exploring its emerging therapeutic applications.
The book begins with four chapters that review the potential applications, possible advantages, and phylogeny of enzybiotics. Next, the book explores:
The authors, all active enzybiotics researchers, offer a variety of perspectives, the benefit of their own hands-on investigations, as well as a thorough review and analysis of the current literature.
As more and more bacteria become resistant to antibiotics, the development of new disease-fighting agents has become essential. This book demonstrates the full potential of the emerging field of enzybiotics to control infectious diseases. Moreover, it will serve as a springboard for new research and the development of new therapeutics.
1 Enzybiotics and Their Potential Applications in Medicine Jan Borysowski Andrzej Górski 1
2 Advantages and Disadvantages in the Use of Antibiotics Or Phages As Therapeutic Agents Patricia Veiga-Crespo Tomas G. Villa 27
3 Enzybiotics as Selective Killers of Target Bacteria Juan C. Alonso Marcelo E. Tolmasky 59
4 Phylogeny of Enzybiotics Patricia Veiga-Crespo Tomas G. Villa 75
5 Bacteriophage Lysins: The Ultimate Enzybiotic Vincent A. Fischetti 107
6 Bacteriophage Holins and their Membrane-Disrupting Activity María Gassest 123
7 Anti-Staphylococcal Lytic Enzymes Jan Borysowski Andrzej Górski 149
8 Membrane-Trageted Enzybiotics María Gasset 173
9 Design of Phage Cocktails For Therapy From a Host Range Point of Veiw Lawrence D. Goodridge 199
10 Identifying Phage Lytic Enzymes: Past, Present, and Future Jonathan E. Schmitz Raymond Schuch Vincent A. Fischetti 219
11 Use of Genetically Modified Phages to Deliver Suicidal Genes to target Bacteria Lawrence D. Goodridge 253
Concluding Remarks: The Future of Enzybiotics Patricia Veiga-Crespo Tomas G. Villa 269