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Enzyme Kinetics: From Diastase to Multi-enzyme Systems

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This textbook for advanced courses in enzyme chemistry and enzyme kinetics covers the field of steady state enzyme kinetics from the basic principles inherent in the Henri equation to the expressions which describe the control of multi-enzyme pathways. Steady state kinetic equations are derived with the use of the connection matrix method, and an algorithm which can be implemented easily for computer-based derivation of the equations is developed. Throughout the book emphasis is placed on a proper interpretation of the kinetic behavior of multi-reactant enzymic reactions. The principles of analytical geometry and basic calculus are employed to analyze non-hyperbolic substrate saturation curves in terms of the mechanisms, including subunit interactions, which cause the deviation from hyperbolic curves. Sensitivity theory is employed to obtain expressions for flux and concentration control coefficients for multi-enzyme pathways. The algorithm developed can be incorporated into a computer-based program for derivation. Emphasis is placed on the interpretation of control coefficients in terms of metabolic control. Problems are included at the end of each chapter and their solutions are found at the end of the book.
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Editorial Reviews

From the Publisher
"Currently, very few introductions to enzyme kinetics are available; this book could serve either as a text for a course in enqyme kinetics or as a reference for those needing an introduction to steady state enzyme kinetics. Definitely recommended." L.M. Prescott, Choice
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Product Details

  • ISBN-13: 9780521445009
  • Publisher: Cambridge University Press
  • Publication date: 6/28/2003
  • Pages: 260
  • Product dimensions: 5.98 (w) x 8.98 (h) x 0.75 (d)

Table of Contents

Pt. 1 Basic steady state enzyme kinetics
1 Derivation of a rate equation 3
2 A closer look at the basic assumptions 22
3 Enzyme inhibition 30
4 Reversible enzyme-catalyzed reactions 44
Pt. 2 Enzyme reaction sequence
5 Multi-reactant enzymic reactions 59
6 Analysis of multi-reactant enzyme kinetics 77
7 Prediction of reaction sequence 92
8 Enzyme-catalyzed isotopic exchange 103
9 Kinetic isotope effect on steady state parameters 114
10 The effect of pH on enzyme kinetics 120
Pt. 3 Non-hyperbolic enzyme kinetics
11 The causes of non-hyperbolic enzyme kinetics 133
12 Analysis of non-hyperbolic enzyme kinetics 140
13 The effect of subunit interactions on enzyme kinetics 153
Pt. 4 Control of multi-enzyme systems
14 Control of linear multi-enzyme systems 169
15 Control of branched multi-enzyme systems 189
16 Biochemical systems theory 199
Pt. 5 Solutions to problems
Author index 241
Subject index 244
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