Enzyme Systems that Metabolise Drugs and Other Xenobiotics / Edition 1

by Costas Ioannides

Overview

This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:
* enzyme function in the metabolism and bioactivation of xenobiotics
* substrate specificity
* tissue distribution
* species distribution (to include laboratory animals and humans)
* hormonal regulation
* sex differences
* modulation by prior exposure to other chemicals
* age-dependent expression
* pharmacogenetics and modulation by disease.
Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.

Product Details

ISBN-13:	9780471894667
Publisher:	Wiley
Publication date:	12/21/2001
Series:	Current Toxicology , #2
Pages:	588
Product dimensions:	6.30(w) x 9.30(h) x 1.40(d)

About the Author

Costas Ioannides is the author of Enzyme Systems that Metabolise Drugs and Other Xenobiotics, published by Wiley.

Table of Contents

Xenobiotic Metabolism: An Overview (Ionnides)

Cytochrome P450 (Guengerich)

Flavin Monooxygenases (Cashman)

Amine Oxidases and the Metabolism of Xenobiotics (Tipton and Benedetti)

Molybdenum Hydroxylases (Beedham)

Prostaglandin Synthases (Degen et al)

Lipoxygenases (Kulkarni)

UDP-Glucuronosyltranferases (Bock)

Glutathione S-transferases (Sherratt and Hayes)

Sulphotransferases (Glatt)

Arylamine Acetyltransferases (Levy and Weber)

Mammalian Xenobiotic Epoxide Hydrolases (Arand and Oesch)

Methyltransferases (Creveling)

The Amino Acid Conjugations (Steventon and Hutt)

Deconjugating Enzymes;
Sulphatases and Glucuronidases (Kunert-Keil et al)

Nitroreductases and Azoreductases (Zbaida)

What People are Saying About This

From the Publisher

"an invaluable reference book" (ISSX Newsletter, Summer 2002)

Editorial Reviews

Pharmacologists and biochemists from Europe and the US synthesize the knowledge to date on the xenobiotic metabolizing enzyme system, combining discussions of most enzyme systems utilized in both phases of metabolism, rather than a single system as previous references have done. Each chapter focuses on a specific enzyme system, detailing substrate specificity; underlying mechanisms of action, especially its role in activating and detoxifying xenobiotics; tissue and species distribution; age-dependent development; sex differences; and the endogenous and exogenous factors that regulate its activity. Veteran and neophyte chemists assessing safety and risk associated with new drugs or drug interactions might find useful information. Annotation c. Book News, Inc., Portland, OR (booknews.com)

"an invaluable reference book" (ISSX Newsletter, Summer 2002)

From the Publisher