Enzymology and Molecular Biology of Carbonyl Metabolism: Aldehyde Dehydrogenase, Aldo-Keto Reductase, and Alcohol Dehydrogenase

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Proceedings of the Sixth International Workshop on [title], held near Dublin, Ireland in June 1992. The volume is divided into sections covering aldehyde dehydrogenase (26 papers), aldose reductase (eight papers) carbonyl reductase (six papers), and alcohol dehydrogenase (24 papers). Site directed mutagenesis to probe for the active site of an enzyme has become part of traditional enzymology, and many of the presenters now use this tool to study some aspect of structure and function of the carbonyl metabolizing enzymes. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

Table of Contents

1 The Big Book of Aldehyde Dehydrogenase Sequences: An Overview of the Extended Family 1
2 Reaction-Chemistry-Directed Sequence Alignment of Aldehyde Dehydrogenases 9
3 Three-Dimensional Structure of Mitochondrial Aldehyde Dehydrogenase: Mechanistic Implications 15
4 A Structural Explanation for the Retinal Specificity of Class 1 ALDH Enzymes 27
5 Structure and Function of Betaine Aldehyde Dehydrogenase: An Enzyme within the Multienzyme Aldehyde Dehydrogenase System 39
6 Evaluation of the Roles of the Conserved Residues of Aldehyde Dehydrogenase 45
7 Aldehyde Dehydrogenase Catalytic Mechanism: A Proposal 53
8 Inhibition of Human Mitochondrial Aldehyde Dehydrogenase by Metabolites of Disulfiram and Structural Characterization of the Enzyme Adduct by HPLC-Tandem Mass Spectrometry 61
9 Mechanism of Inhibition of Rat Liver Class 2 ALDH by 4-Hydroxynonenal 71
10 Aldehyde Inhibitors of Aldehyde Dehydrogenases 79
11 Covalent Modification of Sheep Liver Cytosolic Aldehyde Dehydrogenase by the Oxidative Addition of Coloured Phenoxazine, Phenothiazine and Phenazine Derivatives 89
12 A Thioeater Analogue of an Amino Acctylenic Aldehyde Is a Suicide Inhibitor of Aldehyde Dehydrogenase and an Inducer of Apoptosis in Mouse Lymphoid Cells Overexpressing the bcl2 Gene 97
13 Reaction between Sheep Liver Mitochondrial Aldehyde Dehydrogenase and a Chromogenic 'Reporter Group' Reagent 107
14 Activity of the Human Aldehyde Dehydrogenase 2 Promoter Is Influenced by the Balance between Activation by Hepatocyte Nuclear Factor 4 and Repression by Perosixome Proliferator Activated Receptor [delta], Chicken Ovalbumin Upstream Promoter-Transcription Factor, and Apolipoprotein Regulatory Protein-1 115
15 [alpha],[beta]-Unsaturated Aldehydes Mediate Inducible Expression of Glutathione S-Transferase in Hepatoma Cells through Activation of the Antioxidant Response Element (ARE) 123
16 Effect of Arachidonic Acid Alone or with Prooxidant on Aldehyde Dehydrogenases in Hepatoma Cells 133
17 Prepubertal Regulation of the Rat Dioxin-Inducible Aldehyde Dehydrogenase (ALDH3) 143
18 Effects of Tamoxifen and Toremifene on ALDH1 and ALDH3 in Human Retinal Pigment Epithelial Cells and Rat Liver 151
19 Negative Regulation of Rat Hepatic Aldehyde Dehydrogenase 3 by Glucocorticoids 159
20 Modulation of Class 3 Aldehyde Dehydrogenase Gene Expression: An Eye Opening Experience 165
21 Susceptibility of Hepatoma Cells to Lipid Peroxidation and Adaptation of ALDH 3C Activity to Iron-Induced Oxidative Stress 171
22 The Lack of AHD4 Induction by TCDD in Corneal Cells May Involve Tissue-Specific Regulatory Proteins 181
23 Human Corneal and Lens Aldehyde Dehydrogenases: Localization and Function(s) of Ocular ALDH1 and ALDH3 Isozymes 189
24 The Role of Retinoid Metabolism by Alcohol and Aldehyde Dehydrogenases in Differentiation of Cultured Neuronal Cells 199
25 Metabolism of Retinaldehyde by Human Liver and Kidney 205
26 The Hunt for a Retinal-Specific Aldehyde Dehydrogenase in Sheep Liver 213
27 Cardiac Metabolism of Enals 223
28 Oxidation of Ethanol to Acetaldehyde in Brain and the Possible Behavioral Consequences 231
29 Cloning and Expression of a cDNA Encoding a Constitutively Expressed Rat Liver Cytosolic Aldehyde Dehydrogenase 237
30 The Roles of Acetaldehyde Dehydrogenases in Saccharomyces Cerevisiae 243
31 Characterization of an Aldehyde Dehydrogenase Gene Fragment from Mung Bean (Vigna radiata) Using the Polymerase Chain Reaction 249
32 Aldehyde Dehydrogenase Gene Superfamily: The 1998 Update 255
33 Human Alcohol Dehydrogenase Family: Functional Classification, Ethanol/Retinol Metabolism, and Medical Implications 265
34 Dynamics in Alcohol Dehydrogenase Elucidated from Crystallographic Investigations 275
35 Studies on Variants of Alcohol Dehydrogenases and Its Domains 285
36 Uncompetitive Inhibitors of Alcohol Dehydrogenases 295
37 Tandem Mass Spectrometry of Alcohol Dehydrogenase and Related Biomolecules 305
38 Function of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Gene Families in Retinoid Signaling 311
39 Primary Role of Alcohol Dehydrogenase Pathway in Acute Ethanol-Induced Impairment of Protein Kinase C-Dependent Signaling System 321
40 Class II Alcohol Dehydrogenase: A Suggested Function in Aldehyde Reduction 331
41 Zinc Binding Characteristics of the Synthetic Peptide Corresponding to the Structural Zinc Site of Horse Liver Alcohol Dehydrogenase 339
42 Amphibian Alcohol Dehydrogenase: Purification and Characterization of Classes I and III from Rana perezi 343
43 Extracellular Acidification: A Novel Detection System for Ligand/Receptor Interactions: Demonstration with Bioactive Peptides and CHO or Pancreatic [beta] Cells, but of Possible Interest for Tracing Putative Receptors in Ethanol Metabolism 351
44 Multiplicity and Complexity of SDR and MDR Enzymes 359
45 Regulatory Factors and Motifs in SDR Enzymes 365
46 Bioinformatics in Studies of SDR and MDR Enzymes 373
47 The Protective Role of 11[beta]-Hydroxysteroid Dehydrogenase/Carbonyl Reductase against Tobacco-Smoke Related Lung Cancer 379
48 Structure-Function Relationships of 3[beta]-Hydroxysteroid Dehydrogenases Involved in Bile Acid Metabolism 389
49 Cloning and Sequencing of a New Comamonas testosteroni Gene Encoding 3[alpha]-Hydroxysteroid Dehydrogenase/Carbonyl Reductase 395
50 Comparative Properties of Three Pteridine Reductases 403
51 Effect of Androgen Structures on the Inhibition of Metyraponeinreductase in Rat, Mouse, and Human Liver 411
52 Physiological Relevance of Aldehyde Reductase and Aldose Reductase Gene Expression 419
53 The Aldo-Keto Reductases and Their Role in Cancer 427
54 Structure-Function Studies of FR-1: A Growth Factor-Inducible Aldo-Keto Reductase 435
55 4-Hydroxynonenal Metabolism by Aldo/Keto Reductase in Hepatoma Cells 445
56 Interconversion Pathways of Aldose Reductase Induced by Thiol Compounds 453
57 Aldo-Keto Reductases in Norepinephrine Metabolism 459
58 Rotamers of Tolrestat and Their Binding Mode to Aldose Reductase 465
59 Stereoselective High-Affinity Reduction of Ketonic Nortriptyline Metabolites and of Ketotifen by Aldo-Keto Reductases from Human Liver 473
60 Formation of Lens Aldose Reductase Mixed Disulfides with GSH by UV Irradiation and Its Proteolysis by Lens Calpain 481
61 Inhibition of Aldose Reductase by Gossypol and Gossypol-Related Compounds 487
62 Inhibition of Human Aldose and Aldehyde Reductases by Non-Steroidal Anti-Inflammatory Drugs 493
63 Regulation of Aldose Reductase by Aldehydes and Nitric Oxide 501
64 The Cytoxicity of Methylglyoxal and 3-Deoxyglucosone Is Decreased in the Aldehyde Reductase Gene-Transfected Cells 509
65 Enzymes Metabolizing Aldehydes in HL-60 Human Leukemic Cells 517
66 Rat Carbonyl Reductase: How Many Genes? 523
67 Cytostatic Drug Resistance: Role of Phase-I Daunorubicin Metabolism in Cancer Cells 529
68 Expression of mRNAs for Dihydrodiol Dehydrogenase Isoforms in Human Tissues 539
69 Alterations in the Expression of Daunorubicin Phase-I Metabolising Enzymes in Different Carcinoma Cell Lines 545
Index 553
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