Epigenetics and Cancer, Part A

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Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity.

• Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models

• Includes methods for testing with ethical, legal, and social implications

• Critically analyzes future prospects

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Product Details

  • ISBN-13: 9780123808660
  • Publisher: Elsevier Science
  • Publication date: 11/3/2010
  • Pages: 394
  • Product dimensions: 5.80 (w) x 9.10 (h) x 1.20 (d)

Table of Contents

  1. Introduction, objectives of the book
  2. Zdenko Herceg and Toshikazu Ushijima

    Section I. Basic epigenetic mechanisms in the regulation of critical cellular processes

  3. DNA methylation and cancer
  4. Manel Esteller

  5. Histone modifications and cancer
  6. Zdenko Herceg

  7. Epigenetics and miRNAs in human cancer
  8. George A Calin

  9. Interplay between different epigenetic mechanisms
  10. Rabih Murr

    Section II. Epigenetic events underlying biological phenomena

  11. Genomic imprinting and cancer
  12. Eamonn Maher

  13. Epigenetic code and stem cells
  14. Yasuhiro Yamada

  15. Inheritance of epigenetic aberrations (constitutional epimutations) in cancer susceptibility
  16. Megan Hitchins

    Section III. Cancer epigenome

  17. Cancer epigenome
  18. Stephan Beck

  19. Identification of driver methylation by epigenomic analysis
  20. Gerd Pfeifer

  21. Epigenetic driver of genetic alterations
  22. Minoru Toyota

    Section VI. Epigenetic therapy and epigenetic drugs

  23. DNA demethylating agents and epigenetic therapy of cancer
  24. Mani Samson and Zdenko Herceg

  25. Histone modification therapy of cancer

Severio Minucci

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