Epigenetics in Health and Disease / Edition 1

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This is the first comprehensive, authoritative, and easy-to-understand introduction to modern epigenetics. Authored by two active researchers in the field, it introduces key concepts one step at a time, enabling students at all levels to benefit from it. The authors begin by presenting a historical overview that places epigenetics in context, and makes it clear that the field is not (as some presume) completely new. Next, they introduce and explain key epigenetic mechanisms, and discuss the roles these mechanisms may play in inheritance, organism development, health and disease, behavior, evolution, ecology, and the interaction of individual organisms with their environments. Coverage includes: non-coding RNAs in each kingdom; allelic interactions; CRYSPR; gene silencing; epigenetics of germline and epigenetic memory; epigenetic regulation of genome stability and plant stress response; and much more. The authors conclude by offering significant new insights into how knowledge of epigenetics and epigenomics may promote the development of technologies and solutions in areas ranging from behavioral neuroscience to cancer treatment, toxicology to the development of hardier crops.

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Product Details

  • ISBN-13: 9780132597081
  • Publisher: FT Press
  • Publication date: 6/7/2012
  • Series: FT Press Science Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 608
  • Product dimensions: 6.90 (w) x 8.80 (h) x 0.70 (d)

Meet the Author

Igor Kovalchuk, Ph.D., MD, is Professor and Board of Governors Research Chair at the Department of Biological Sciences, University of Lethbridge (Alberta, Canada). He edits Frontiers in Plant Microbe Interaction, Frontiers in Epigenomics, and other journals. As principal investigator in the university’s Plant Biotechnology laboratory, he studies genetic and epigenetic regulation of plant response to stress, including the transgenerational effects of stress and microevolution of plant stress tolerance/resistance.

Olga Kovalchuk, Ph.D., MD is Professor and Board of Governors Research Chair and CIHR Chair in Gender and Health at the University of Lethbridge and a member of the editorial boards of Mutation Research--Fundamental and Molecular Mechanisms of Mutagenesis and Environmental and Molecular Mutagenesis. She researches the role of epigenetic dysregulation in carcinogenesis; epigenetic regulation of cancer treatment responses; radiation epigenetics and role of epigenetic changes in genome stability and carcinogenesis; radiation-induced oncogenic signaling; and radiation-induced DNA damage, repair, and recombination.

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Table of Contents

1 Historical Perspective 1

2 Chromatin Dynamics and Chromatin Remodeling in Animals 19

3 Chromatin Dynamics and Chromatin Remodeling in Plants 49

4 DNA Methylation as Epigenetic Mechanism 75

5 Histone Modifications and Their Role in Epigenetic Regulation 119

6 Realm of Non-Coding RNAs-From Bacteria to Human 147

7 Non-Coding RNAs Involved in Epigenetic Processes-A General Overview 177

8 Non-Coding RNAs Across the Kingdoms-Bacteria and Archaea 203

9 Non-Coding RNAs Across the Kingdoms-Protista and Fungi 223

10 Non-Coding RNAs Across the Kingdoms-Animals 267

11 Non-Coding RNAs Across the Kingdoms-Plants 297

12 Non-Coding RNAs-Comparison of Biogenesis in Plants and Animals 327

13 Paramutation, Transactivation, Transvection, and Cosuppression-Silencing of Homologous Sequences 343

14 Bacterial Adaptive Immunity-Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) 385

15 Gene Silencing-Ancient Immune Response and a Versatile Mechanism of Control over the Fate of Foreign Nucleic Acids 409

16 Epigenetics of Germline and Epigenetic Memory 435

17 Epigenetics of Health and Disease-Cancer 465

18 Epigenetics of Health and Disease-Behavioral Neuroscience 499

19 Epigenetics of Health and Disease-Diet and Toxicology, Environmental Exposures 523

20 Epigenetics and Technology-Hairpin-Based Antisensing 555

Index 577

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