EPIGENETICS IN HUMAN REPRODUCTION AND DEVELOPMENT

EPIGENETICS IN HUMAN REPRODUCTION AND DEVELOPMENT

EPIGENETICS IN HUMAN REPRODUCTION AND DEVELOPMENT

EPIGENETICS IN HUMAN REPRODUCTION AND DEVELOPMENT

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Overview

Epigenetics is defined as heritable changes that do not affect the DNA sequence but influence gene expression. Epigenetic changes occur at the levels of DNA, histone, protein, and chromatin structures. Proper epigenetic modifications are essential for cell differentiation and function during development, while some epigenetic modifications are passed on from parents to offspring through gametes. Therefore, alterations of epigenetic states would have serious consequences for human development and health. This realization and the advent of new technologies have encouraged the advance of epigenetic studies in recent years. Nonetheless, many aspects of epigenetics, such as regulatory mechanisms and evolutional advantages, remain to be better understood.Written by 26 scientists at the forefront of epigenetics research, this book discusses the different facets of epigenetics: from gametogenesis to child development, as well as from mechanistic studies in animal models to reviews of human clinical data.

Product Details

ISBN-13: 9789813144286
Publisher: World Scientific Publishing Company, Incorporated
Publication date: 12/20/2016
Sold by: Barnes & Noble
Format: eBook
Pages: 304
File size: 4 MB

Table of Contents

Preface v

Chapter 1 Epigenetics and Transposon Control in the Mammalian Germline Safia Malki Alex Bortoin 1

Chapter 2 Epigenetic Modifications during Mammalian Oogenesis: Emerging Roles of Chromatin Structure during Oocyte Growth and Meiotic Maturation Rabindranath De La Fuente Claudia Baumann Maria M. Viveiros 35

Chapter 3 Meiotic Recombination in the Human Germ Line Fatima Smagulova 59

Chapter 4 Epigenetics of Male Infertility Debbie Montjean Antoine D. Rolland Celia Ravel 87

Chapter 5 Epigenetic Regulation of X-Chromosome Inactivation Bernhard Payer 113

Chapter 6 Placentation and Genomic Imprinting Courtney W. Hanna Wendy P. Robinson 159

Chapter 7 Genetic and Epigenetic Variation at the H19 Imprinted Region and Its Effect on Birth Weight Celia M T Greenwood Changjiang Xu Shomoita Alam Julia Krushkal Ronald M. Adkins Anna K. Naumova 185

Chapter 8 Disturbances in Folate Metabolism and Their Impact on Development Renala H. Bahous Karen E. Christensen Rima Rozen 209

Chapter 9 Early Life Experiences and Their Influence on Epigenetic Marks and Human Brain Development Alike Hoffmann Diet mar Spengler 239

Chapter 10 Epigenetic Consequences of Human Assisted Reproductive Technologies Debra L. Fulton Seang Lin Tan Teruko Taketo 273

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