Epigenetics

Overview

Epigenetics pertains to the development of an organism from an undifferential cell, resulting in the successive formation and development of organs and parts that did not pre-exist in the fertilized egg. An exciting and stimulating volume which used the extensive knowledge of basic transcriptional control as a foundation to explore the more complex and interesting level at which genes can be regulated.

Discusses current understanding of molecular mechanisms that ...

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1998 Hard cover New. No dust jacket as issued. Excellent as new condition, mint. A brand new copy. Sewn binding. Cloth over boards. 304+ pages, includes index and illustrations. ... Novartis Foundation Symposium, 214. *****PLEASE NOTE: This item is shipping from an authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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1998 Hard cover New. No dust jacket as issued. Excellent as new condition, mint. A brand new copy. Sewn binding. Cloth over boards. 304+ pages, includes index and illustrations. ... Novartis Foundation Symposium, 214. *****PLEASE NOTE: This item is shipping from an authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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1998 Hard cover New. No dust jacket as issued. Excellent as new condition, mint. A brand new copy. Sewn binding. Cloth over boards. 304+ pages, includes index and illustrations. ... Novartis Foundation Symposium, 214. *****PLEASE NOTE: This item is shipping from an authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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Overview

Epigenetics pertains to the development of an organism from an undifferential cell, resulting in the successive formation and development of organs and parts that did not pre-exist in the fertilized egg. An exciting and stimulating volume which used the extensive knowledge of basic transcriptional control as a foundation to explore the more complex and interesting level at which genes can be regulated.

Discusses current understanding of molecular mechanisms that direct epigenetic phenomena & future work & solutions.

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Product Details

  • ISBN-13: 9780471977711
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 4/13/1998
  • Series: Novartis Foundation Symposia Series , #137
  • Edition number: 1
  • Pages: 201
  • Product dimensions: 6.22 (w) x 9.31 (h) x 0.83 (d)

Table of Contents

Introduction 1
Gene silencing by methyl-CpG-binding proteins 6
Discussion 16
DNA methylation, nucleosomes and the inheritance of chromatin structure and function 22
Discussion 35
General discussion I: The methylation of CpG islands 46
Heritable chromatin states induced by the Polycomb and trithorax group genes 51
Discussion 61
The dynamics of globin gene expression and position effects 67
Discussion 79
Multiple epigenetic events regulate mating-type switching of fission yeast 87
Discussion 99
General discussion II: Centromeres 104
Nuclear organization and silencing: trafficking of Sir proteins 114
Discussion 126
Epigenetic mechanisms in the regulation of the maize Suppressor-mutator transposon 133
Discussion 140
Transgene-promoted epigenetic switches of chalcone synthase activity in petunia plants 144
Discussion 154
General discussion III: Nucleolar organization 163
General discussion III: The silencing of endogenous sequences and transgenes 164
Gene silencing in plants: relevance for genome evolution and the acquisition of genomic methylation patterns 168
Discussion 181
The host defence function of genomic methylation patterns 187
Discussion 195
Mammalian X chtomosome inactivation 200
Discussion 209
Methylation dynamics, epigenetic fidelity and X chromosome structure 214
Discussion 225
General discussion IV: Does DNA methylation regulate gene activity? 228
Imprinting and gene silencing in mice and Drosophila 233
Discussion 244
Making sense of imprinting the mouse and human IGF2R loci 251
Discussion 260
Imprinted genes in the Prader-Willi deletion 264
Discussion 275
Final general discussion: Rules of DNA methylation in humans inferred from the fragile X gene, FMRI 280
Summary 291
Index of contributors 293
Subject index 295
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