Epilepsy and the Ketogenic Diet / Edition 1

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The ketogenic diet (KD) has become a significant feature of many epilepsy treatment programs as it has beneficial effects in a substantial proportion of drug-resistant epilepsies. However, there are a large number of uncertainties and mysteries regarding its application and mechanisms of action, and this book aims to answer these questions for both practicing physicians and scientists studying KD. It covers everything from the clinical aspects of KD formulation, administration and clinical use through to strategies for tailoring individual KD diets and monitoring its effectiveness.

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Editorial Reviews

From the Publisher
Foreword by Philip A. Schwartzkroin, PhD

"This book is a comprehensive summary of the use of the ketogenic diet for treatment of medically intractable epilepsy. This book should be read by all those caring for patients with medically intractable epilepsy, and should be on the shelves of all those involved in supervising the ketogenic diet."-The Lancet

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Product Details

  • ISBN-13: 9781617374777
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/9/2010
  • Series: Nutrition and Health Series
  • Edition description: Softcover reprint of hardcover 1st ed. 2004
  • Edition number: 1
  • Pages: 355
  • Product dimensions: 0.77 (w) x 7.00 (h) x 10.00 (d)

Table of Contents

Part I. Background

An Introduction to Seizures and Epilepsy: Cellular Mechanisms Underlying Classification and Treatment
Carl E. Stafstrom

History and Origin of the Ketogenic Diet
James W. Wheless

Part II. Clinical Aspects

The Ketogenic Diet: The Physician's Perspective
Eric H. Kossoff and John M. Freeman

Clinical Use of the Ketogenic Diet: The Dietitian's Role
Beth Zupec-Kania, Rhonda Roell Werner, and Mary L. Zupanc

How to Maintain and Support a Ketogenic Diet Program: A Nursing Perspective
Jeri E. Nichols Sutherling and Danine Mele-Hayes

Efficacy of the Ketogenic Diet
James E. Rubenstein and Eileen P. G. Vining

The Ketogenic Diet in Adults
Michael R. Sperling and Maromi Nei

Indications and Contraindications of the Ketogenic Diet
Anna Gunhild Christina Bergqvist

Complications of the Ketogenic Diet
Karen R. Ballaban-Gil

Measuring and Interpreting Ketosis and Fatty Acid Profiles in Patients on a High-Fat Ketogenic Diet
Kathy Musa-Veloso and Stephen C. Cunnane

Insights From Neuroimaging Studies Into Ketosis and the Ketogenic Diet
Jullie W. Pan

Potential Applications of the Ketogenic Diet in Disorders Other Than Epilepsy
Rif S. El-Mallakh

Dietary Treatments for Epilepsy Other Than the Ketogenic Diet
Carl E. Stafstrom and Gregory L. Holmes

Part III. Basic Science Perspectives

Effects of the Ketogenic Diet on Cerebral Energy Metabolism
Douglas R. Nordli, Jr. and Darryl C. De Vivo

The Ketogenic Diet: Interactions With Brain Amino Acid Handling
Marc Yudkoff, Yevgeny Daikhin, Ilana Nissim, and Itzhak Nissim

Molecular Regulation of Ketogenesis
Tim E. Cullingford

The Effects of Ketone Bodies on Neuronal Excitability
Sergei S. Likhodii and W. McIntyre Burnham

Effects of the Ketogenic Diet on Acute Seizure Models
Douglas A. Eagles and Kristopher J. Bough

Caloric Restriction and Epilepsy: Historical Perspectives, Relationship to the Ketogenic Diet, and Analysis in Epileptic EL Mice
Thomas N. Seyfried, Amanda E. Greene, and Mariana T. Todorova

The Role of Norepinephrine in the Anticonvulsant Mechanism of Action of the Ketogenic Diet
Patricia Szot

Galanin and Neuropeptide Y: Orexigenic Neuropeptides Link Food Intake, Energy Homeostasis, and Seizure Susceptibility
David Weinshenker

The Neuroprotective and Antiepileptogenic Effects of the Ketogenic Diet
Jong M. Rho

Afterword: A Parent's Perspective on Childhood Epilepsy: The Things I Wish They Had Told Us
Jim Abrahams

Carl E. Stafstrom and Jong M. Rho

Appendix A: The Carbohydrate and Caloric Content of Drugs
George Karvelas, Denis Lebel, and Lionel Carmant

Appendix B: Ketogenic Diet Resources
Carl E. Stafstrom and Jong M. Rho


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