Epilepsy: Mechanisms, Models, and Translational Perspectives / Edition 1

Epilepsy: Mechanisms, Models, and Translational Perspectives / Edition 1

by Jong Rho
     
 

ISBN-10: 142008559X

ISBN-13: 9781420085594

Pub. Date: 06/18/2010

Publisher: Taylor & Francis

Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervous system, have

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Overview

Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervous system, have led to a substantial reduction in the morbidity and mortality of patients with epilepsy. At the same time, remarkable developments in neuroscience have enhanced our understanding of brain structure and function.

Epilepsy: Mechanisms, Models, and Translational Perspectives incorporates new translational advances that bring epilepsy therapies from the laboratory bench to the bedside and back again. It brings together the work of more than 70 of the field’s most respected and cutting-edge researchers and clinicians. In 24 chapters, this extraordinarily comprehensive and current work:

Offers an overview of the basic anatomic and functional substrates of seizure genesis and considers novel pathogenic concepts that have both emerged and been validated experimentally

  • Examines antiepileptic drug therapy, including the latest on molecular targets
  • Looks at the state of surgical treatments for epilepsy and discusses advances in the fields of structural and functional neuroimaging
  • Reviews the variety of nontraditional therapeutic options, such as the ketogenic diet, the vagus nerve stimulator, immunomodulators, neurosteroids, herbs, and botanicals
  • Investigates neuroendocrine, hormonal, and biobehavioral factors that influence seizure susceptibility—information that can be incorporated into the design of treatment algorithms on an individualized basis
  • Provides a glimpse of what future epilepsy therapies might look like, from novel mechanisms of drug delivery to gene and stem-cell therapies for epilepsy to seizure detection methods, to the ultimate goal of disease prevention.

The idea for this book was inspired by the editors’ collective desire to promote bridging of the so-called translational divide—that is, covering innovative treatment strategies based on scientific principles that have yet to be tested rigorously in the clinical setting, but yet may provide practitioners with new and promising approaches toward epilepsy therapeutics.

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Product Details

ISBN-13:
9781420085594
Publisher:
Taylor & Francis
Publication date:
06/18/2010
Pages:
684
Product dimensions:
7.20(w) x 10.10(h) x 1.30(d)

Table of Contents

Section I Scientific Foundations
Pathophysiological Mechanisms of Seizures and Epilepsy: A Primer, Carl E. Stafstrom
Blood–Brain Barrier, Blood Flow, Neoplasms, and Epilepsy: The Role of Astrocytes, Luca Cucullo, Nicola Marchi, Vincent Fazio,
Minh-Tri Nguyen, and Damir Janigro
Metabolic Regulation of Seizures and Epileptogenesis, Manisha Patel
Brain Inflammation and Epilepsy, Teresa Ravizza, Silvia Balosso, Eleonora Aronica, and Annamaria Vezzani
Drug Resistance in Epilepsy and Status Epilepticus, Jaideep Kapur and Edward H. Bertram
Epilepsy with Complex Genetics: Looking Beyond the Channelopathies, Asuri N. Prasad and Chitra Prasad
Pathophysiology of Developmental Epilepsies, Judith L.Z. Weisenberg and Michael Wong

Section II Antiepileptic Drugs
Mechanisms of Antiepileptic Drug Action, Timothy A. Simeone
Epilepsy and Disease Modification: Animal Models for Novel Drug Discovery, H. Steve White
Pharmacogenetics of AED Development, Russell J Buono, Thomas N. Ferraro, Dennis J. Dlugos, and Karen S. Wilcox
Neuroprotective Strategies Using Antiepileptic Drugs, Patrick G. Sullivan and Ryan D. Readnower
Posttraumatic Seizures and Epileptogenesis: Good and Bad Plasticity, Christopher C. Giza
Possible Roles of Nonsynaptic Mechanisms in Synchronization of Epileptic Seizures: Potential Antiepileptic Targets? F. Edward Dudek, Li-Rong Shao, and John E. Rash
A Mechanistic Approach to Antiepileptic Drug Interactions, Gail D. Anderson

Section III Epilepsy Surgery
Advances in Structural and Functional Neuroimaging: How Are These Guiding Epilepsy Surgery? Hyunmi Kim, A. LeBron Paige, and Robert C. Knowlton
Magnetoencephalography in Clinical Epilepsy: A Translational Viewpoint, Jerry J. Shih and Michael P. Weisend
What Have We Learned from Resective Surgery in Pediatric Patients with Cortical Dysplasia?, Carlos Cepeda and Gary W. Mathern
Nonsurgical Ablation for Epilepsy, Erich O. Richter, Marina V. Abramova, William A. Friedman, and Steven N. Roper
Deep Brain Stimulation for Epilepsy, Francisco Velasco, Ana Luisa Velasco, Luisa Rocha, Marcos Velasco, Jose D. Carrillo-Ruiz, Manoela Cuellar, Guillermo Castro, Fiacro Jimenez, and David Trejo
Optical Imaging Techniques in Pediatric Neocortical Epilepsy, Daryl W. Hochman and Michael M. Haglund
High-Frequency Oscillations in Epileptic Brain, S. Matt Stead, Mark Bower, and Greg Worrell

Section IV Alternative Therapies
Special Treatments in Epilepsy, Kevin Chapman and James W. Wheless
Herbs and Botanicals, Steven C. Schachter
The Ketogenic Diet: Scientific Principles Underlying Its Use, Kristopher J. Bough and Carl E. Stafstrom
Vagus Nerve Stimulation, Matthew M. Troester and Dean K. Naritoku
Antiinflammatory Treatments for Seizure Syndromes and Epilepsy, Stéphane Auvin and Raman Sankar

Section V Other Modulators of the Epileptic State
Impact of Neuroendocrine Factors on Seizure Genesis and Treatment, Pavel Klein and Jaromir Janousek
Neurosteroid Replacement Therapy for Catamenial Epilepsy, Doodipala S. Reddy and Michael A. Rogawski
Chronobiology and Sleep: Implications for Seizure Propensity, Mark Quigg
Pediatric Epilepsy: A Developmental Neuropsychiatric Disorder, Rochelle Caplan

Section VI The Future of Epilepsy Therapy
Novel Mechanisms of Drug Delivery, Vijay Ivaturi and James Cloyd
Early Seizure Detection: Considerations and Applications, Christophe C. Jouny, Piotr J. Franaszczuk, and Gregory K. Bergey
Gene and Stem Cell Therapies for Treating Epilepsy, Janice R. Naegele and Xu Maisano
Arresting Epileptogenesis: The Current Challenge, Philip A. Schwartzkroin

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