Escherichia Coli: Mechanisms of Virulence

Overview

This comprehensive compilation, written by an authoritative team of international contributors, surveys the role of Escherichia coli in health and disease. The potential of E. coli as a pathogen has increasingly been recognised in recent years and its mechanisms of virulence have been extensively investigated. This most valuable and timely account brings the subject fully up to date. First the diseases due to E. coli in man and animals are described in general terms and the part it plays in the normal flora. Then...

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Overview

This comprehensive compilation, written by an authoritative team of international contributors, surveys the role of Escherichia coli in health and disease. The potential of E. coli as a pathogen has increasingly been recognised in recent years and its mechanisms of virulence have been extensively investigated. This most valuable and timely account brings the subject fully up to date. First the diseases due to E. coli in man and animals are described in general terms and the part it plays in the normal flora. Then chapters are devoted to each of the recognised virulence factors and mechanisms, including capsules, adhesins, haemolysins, endotoxins and exotoxins, iron scavenging. The third section deals in detail with various diseases and their mechanisms. Finally, the host responses to infection are considered and the design of vaccines. This book will be of value to all scientists and clinicians with an interest in microbial pathogenicity.

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Product Details

  • ISBN-13: 9780521453615
  • Publisher: Cambridge University Press
  • Publication date: 3/28/1997
  • Edition number: 1
  • Pages: 639
  • Product dimensions: 5.98 (w) x 8.98 (h) x 1.46 (d)

Table of Contents

List of contributors
Preface
Pt. 1 Introduction 1
1 Escherichia coli and human disease 3
2 Escherichia coli infections in farm animals 49
3 Escherichia coli in the normal flora of humans and animals 85
Pt. 2 Virulence factors 111
4 Capsules of Escherichia coli 113
5 Escherichia coli lipopolysaccharide in pathogenesis and virulence 145
6 Type-1 fimbriae of Escherichia coli 169
7 Fimbriae of enterotoxigenic Escherichia coli 193
8 Assembly of adhesive virulence-associated pili in Gram-negative bacteria 213
9 The heat-labile and heat-stable enterotoxins of Escherichia coli 237
10 Vero cytotoxins 257
11 Haemolysins of Escherichia coli 281
12 Iron and the virulence of Escherichia coli 331
13 Co-ordinate regulation of virulence gene expression in Escherichia coli 373
Pt. 3 Mechanisms of disease 401
14 Enteropathogenic Escherichia coli 403
15 Vero-cytotoxin-producing Escherichia coli 421
16 Enteroinvasive Escherichia coli 449
17 Soft tissue infection and septicaemia 469
18 Urinary tract infection 495
Pt. 4 Responses to infection 551
19 Cellular activation by uropathogenic Escherichia coli 553
20 Immune responses to Escherichia coli 579
21 Vaccines against enterotoxigenic Escherichia coli 605
Index 627
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