Section 1: Groundwork.
1 The excitement of developmental biology.
Where the subject came from.
Central position in biology.
Impact on society.
2 Common features of development.
Genomic equivalence, cloning of animals.
Growth and death.
3 Developmental genetics.
Screening for mutants.
Cloning of genes.
4 Experimental embryology.
Acquisition of commitment.
Criteria for proof.
5 Techniques for the study of development.
Study of gene expression by biochemical methods.
Study of gene expression by in situ methods.
Section 2: Major model organisms.
6 Model organisms.
The big six.
Availability and cost.
Access and micromanipulation.
Genetics and genome maps.
Relevance and tempo.
Oogenesis, maturation, fertilization.
8 The zebrafish.
9 The chick.
Regional specification of the early embryo.
Description of organogenesis in the chick.
10 The mouse.
Normal embryonic development.
Technology of mouse development.
Regional specification in development.
Other topics in mouse development.
Drosophila developmental genetics.
Overview of the developmental program.
The dorsoventral pattern.
The anteroposterior system.
12 Caenorhabditis elegans.
Regional specification in the embryo.
Analysis of postembryonic development.
Programmed cell death.
Section 3: Organogenesis.
13 Tissue organization and stem cells.
Types of tissue.
14 Development of the nervous system.
Overall structure and cell types.
Anteroposterior patterning of the neural plate.
Dorsoventral patterning of the neural tube.
Neurogenesis and gliogenesis.
The neural crest.
Development of neuronal connectivity.
15 Development of mesodermal organs.
Somitogenesis and myogenesis.
Germ cell and gonadal development.
Heart and blood vessels.
16 Development of endodermal organs.
Determination of the endoderm.
17 Drosophila imaginal discs.
Genetic study of larval development.
Regional patterning of the wing disc.
Section 4: Growth, regeneration, and evolution.
18 Growth, aging, and cancer.
Size and proportion.
Growth in stature.
Postnatal disorders of growth and differentiation.
19 Regeneration of missing parts.
Distribution of regenerative capacity.
Vertebrate limb regeneration.
20 Evolution and development.
The primordial animal.
What really happened in evolution?
Appendix: Key molecular components.
Transcription factor families.
Inducing factor families.
Cell adhesion molecules.
Extracellular matrix components.