Essential Physiological Biochemistry: An Organ-Based Approach / Edition 1

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Essential Physiological Biochemistry provides a fresh, accessible introduction to human metabolism that shows how the physiological actions of selected organs can be explained by their particular biochemical processes.

Focusing on metabolic integration, rather than pathways, this book opens with three introductory chapters that explore the principles of metabolism and its control before moving onto 'themed' chapters that investigate liver, communication systems (endocrine and neurological), blood and vascular system, muscle and adipose tissue and renal biochemistry.

A fresh, accessible primer that adopts a unique, organ-based approach to human metabolism.

Assumes only a basic understanding of chemistry.

Chapters are arranged specifically to enable readers to grasp key concepts and to aid understanding.

Some chapters include Case Notes, illustrating key aspects of metabolism in cells, tissues and organs.

Targeted at non-biochemistry majors who need to get to grips with key biochemical concepts and ideas, Essential Physiological Biochemistry is an essential guide for all undergraduate biomedical science, sports science, nutrition and other allied health students.

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Product Details

  • ISBN-13: 9780470026359
  • Publisher: Wiley
  • Publication date: 1/26/2010
  • Edition number: 1
  • Pages: 342
  • Product dimensions: 6.80 (w) x 9.70 (h) x 1.00 (d)

Table of Contents

Preface xi

1 Introduction to metabolism 1

Overview of the chapter 1

1.1 Introduction 1

1.2 Metabolic pathways 2

1.3 Organization of pathways 4

1.4 Enzymes and enzyme-mediated reactions 6

1.5 Bioenergetics: an introduction to biological thermodynamics 16

1.6 Enzyme-mediated control of metabolic pathways 17

1.7 Strategy for learning the details of a pathway: 'active learning' is essential 20

Chapter summary 26

Problems and challenges 27

2 Dynamic and quantitative aspects of metabolism: bioenergetics and enzyme kinetics 29

Overview of the chapter 29

2.1 Introduction 29

2.2 Bioenergetics: the application of thermodynamic principles to biological systems 30

2.3 Enzyme kinetics 39

2.4 Energy generating metabolic processes 45

Chapter summary 50

Problems and challenges 52

3 Principles of metabolic control: enzymes, substrates, inhibitors and genes 55

Overview of the chapter 55

3.1 Introduction 55

3.2 General principles 56

3.3 Glycolysis and the Krebs TCA cycle as models of control of metabolic pathways 71

Chapter summary 78

Problems and challenges 79

4 Biochemistry of intercellular communication; metabolic integration and coordination 81

Overview of the chapter 81

Key pathways 81

4.1 Introduction 81

4.2 Physiological aspects 82

4.3 Signalling molecules 85

4.4 Synthesis of hormones 86

4.5 Hormone and neurotransmitter storage, release and transport 95

4.6 Hormone and neurotransmitter inactivation 97

4.7 Target tissue response to signals 99

4.8 Diabetes mellitus 119

Chapter summary 123

Case notes 124

5 Biochemistry of the blood and the vascular system 127

Overview of the chapter 127

Key pathways 127

5.1 Introduction 127

5.2 The blood vascular system 129

5.3 Circulating blood cells 136

5.4 Coagulation and complement: two of the body's defence mechanisms 159

5.5 Blood as a transport medium 160

Chapter summary 166

Case notes 167

6 Biochemistry of the liver 171

Overview of the chapter 171

Key pathways 171

6.1 Introduction 171

6.2 Physiology of the Liver 171

6.3 Synthetic functions 172

6.4 Detoxification and waste disposal 197

6.5 Maintenance of blood glucose concentration 212

Chapter summary 226

Case notes 226

7 Biochemistry of muscle 229

Overview of the chapter 229

Key pathways 229

7.1 Introduction 229

7.2 Physiology of muscles 230

7.3 Fuel metabolism within muscles 236

7.4 Maintenance of ATP availability in active muscle 242

7.5 Fatty acid as a fuel in muscle 248

7.6 Proteins and amino acids as fuels 254

7.7 Fuel utilization by muscle: adaptation to exercise and training 256

Chapter summary 258

Case notes 259

8 Biochemistry of the kidneys 261

Overview of the chapter 261

Key pathways 261

8.1 Introduction 261

8.2 Renal physiology 262

8.3 Metabolic pathways in the kidneys 276

Chapter summary 279

Case notes 279

9 Biochemistry of connective tissue: bone and adipose 283

Overview of the chapter 283

Key pathways 283

9.1 Introduction 283

9.2 Histology of connective tissue 284

9.3 The ECM of connective tissue 284

9.4 Bone 295

9.5 Cartilage 301

9.6 Adipose tissue 301

Chapter summary 308

Case notes 309

Appendix 1 Answers to problems 313

Appendix 2 Table of important metabolic pathways 321

Index 323

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