Essential Practical NMR for Organic Chemistry / Edition 1

Hardcover (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $62.32
Usually ships in 1-2 business days
(Save 26%)
Other sellers (Hardcover)
  • All (10) from $62.32   
  • New (8) from $62.32   
  • Used (2) from $67.26   

Overview

This book describes the use of NMR spectroscopy for dealing with problems of small organic molecule structural elucidation. It features a significant amount of vital chemical shift and coupling information but more importantly, it presents sound principles for the selection of the techniques relevant to the solving of particular types of problem, whilst stressing the importance of extracting the maximum available information from the simple 1-D proton experiment and of using this to plan subsequent experiments. Proton NMR is covered in detail, with a description of the fundamentals of the technique, the instrumentation and the data that it provides before going on to discuss optimal solvent selection and sample preparation. This is followed by a detailed study of each of the important classes of protons, breaking the spectrum up into regions (exchangeables, aromatics, heterocyclics, alkenes etc.). This is followed by consideration of the phenomena that we know can leave chemists struggling; chiral centres, restricted rotation, anisotropy, accidental equivalence, non-first-order spectra etc.  Having explained the potential pitfalls that await the unwary, the book then goes on to devote chapters to the chemical techniques and the most useful instrumental ones that can be employed to combat them.

A discussion is then presented on carbon-13 NMR, detailing its pros and cons and showing how it can be used in conjunction with proton NMR via the pivotal 2-D techniques (HSQC and HMBC) to yield vital structural information. Some of the more specialist techniques available are then discussed, i.e. flow NMR, solvent suppression, Magic Angle Spinning, etc. Other important nuclei are then discussed and useful data supplied. This is followed by a discussion of the neglected use of NMR as a tool for quantification and new techniques for this explained. The book then considers the safety aspects of NMR spectroscopy, reviewing NMR software for spectral prediction and data handling and concludes with a set of worked Q&As.

Read More Show Less

What People Are Saying

From the Publisher
"The style is informal and the content pragmatic with minimal technical detail, making for easy reading. It differs from many other books in trying to explain how organic structures can be confirmed with routine NMR methods without distraction from underlying theory." (Chemistry World, 1 June 2011)
Read More Show Less

Product Details

  • ISBN-13: 9780470710920
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 2/22/2011
  • Edition number: 1
  • Pages: 228
  • Product dimensions: 7.50 (w) x 9.90 (h) x 0.70 (d)

Meet the Author

Steve Richards graduated in Chemistry from Bangor University in 1977 and completed an MSc in Analytical Chemistry at Bristol in 1979. He joined Glaxo Group Research in 1980 and has worked in the NMR spectroscopy department ever since. He has run regular courses in NMR interpretation for new graduates and sandwich students within GSK since the late 80s.

John Hollerton joined the GSK spectroscopy department in 1980. Having spent time working with other spectroscopic techniques, he has been focused on NMR spectroscopy since 1982. He is now the manager with a staff of thirteen scientists working under his direction. John has also lectured internationally on the subject on many occasions.

Read More Show Less

Table of Contents

Introduction.

1. Getting Started.

1.1 The Technique.

1.2 Instrumentation.

1.3 CW Systems.

1.4 FT Systems.

2. Preparing the Sample.

2.1 How Much Sample Do I Need?

2.2 Solvent Selection.

2.3 Spectrum Referencing (Proton NMR).

2.4 Sample Preparation.

3. Spectrum Acquisition.

3.1 Number of Transients.

3.2 Number of Points.

3.3 Spectral Width.

3.4 Acquisition Time.

3.5 Pulse Width/Pulse Angle.

3.6 Relaxation Delay.

3.7 Number of Increments.

3.8 Shimming.

3.9 Tuning and Matching.

3.10 Frequency Lock.

3.11 To Spin or Not to Spin?

4. Processing.

4.1 Introduction.

4.2 Zero Filling and Linear Prediction.

4.3 Apodization.

4.4 Fourier Transformation.

4.5 Phase Correction.

4.6 Baseline Correction.

4.7 Integration.

4.8 Referencing.

4.9 Peak Picking.

5. Interpreting Your Spectrum.

5.1 Common Solvents and Impurities.

5.2 Group 1 – Exchangeables and Aldehydes.

5.3 Group 2 – Aromatic and Heterocyclic Protons.

5.4 Group 3 – Double and Triple Bonds.

5.5 Group 4 – Alkyl Protons.

6. Delving Deeper.

6.1 Chiral Centres.

6.2 Enantiotopic and Diastereotopic Protons.

6.3 Molecular Anistropy.

6.4 Accidental Equivalence.

6.5 Restricted Rotation.

6.6 Heteronuclear Coupling.

7. Further Elucidation Techniques – Part 1.

7.1 Chemical Techniques.

7.2 Deuteration.

7.3 Basification and Acidification.

7.4 Changing Solvents.

7.5 Trifluoroacetylation.

7.6 Lanthanide Shift Reagents.

7.7 Chiral Resolving Agents.

8. Further Elucidation Techniques – Part 2.

8.1 Instrumental Techniques.

8.2 Spin Decoupling (Homonuclear, 1-D).

8.3 Correlated Spectroscopy (2-D).

8.4 Total Correlation Spectroscopy (1- and 2-D).

8.5 The Nuclear Overhauser Effect and Associated Techniques.

9. Carbon-13 NMR Spectroscopy.

9.1 General Principles and 1-D 13C.

9.2 2-D Proton-Carbon (Single Bond) Correlated Spectroscopy.

9.3 2-D Proton-Carbon (Multiple Bond) Correlated Spectroscopy.

9.4 Piecing It All Together.

9.5 Choosing the Right Tool.

10. Some of the Other Tools.

10.1 Linking HPLC with NMR.

10.2 Flow NMR.

10.3 Solvent Suppression.

10.4 Magic Angle Spinning NMR.

10.5 Other 2-D Techniques.

10.6 3-D Techniques.

11. Some of the Other Nuclei.

11.1 Fluorine.

11.2 Phosphorus.

11.3 Nitrogen.

12. Quantification.

12.1 Introduction.

12.2 Relative Quantification.

12.3 Absolute Quantification.

12.4 Things to Watch Out For.

12.5 Conclusion.

13. Safety.

13.1 Magnetic Fields.

13.2 Cryogens.

13.3 Sample-Related Injuries.

14. Software.

14.1 Acquisition Software.

14.2 Processing Software.

14.3 Prediction and Simulation Software.

15. Problems.

15.1 Ten NMR Problems.

15.2 Hints.

15.3 Answers.

Glossary.

Index.

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)