Essentials of Apoptosis: A Guide for Basic and Clinical Research / Edition 1

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Overview

As a fundamental biological process, cell death and cell survival is essential to the normal homeostasis of the organism. Our knowledge on this process has been tremendously expanded in the past two decades. Essentials of Apoptosis: A Guide for Basic and Clinical Research was first published in 2003. It timely provided a comprehensive but concise summary of the essential information of apoptosis to both new investigators to the field and seasoned researchers seeking an integrated view of the topics. The past several years have witnessed significant new developments in the field of apoptosis and cell death in general. The concept of various types of cell death has been further developed. The studies in both basic and clinical disciplines have been greatly expanded. Notable progress has been made in extending the work into the therapeutic arena. As a result, the field has matured considerably and developed extensive crosstalk with works in other fields. The second edition incorporates these new developments, in addition to the basic core concepts and machinery of apoptosis. Multiple new topics are added that expand the coverage on different types of cell death (apoptosis, necrosis, autophagic death and mitotic death), and on different death pathways (mediated by mitochondria, endoplasmic reticulum, death receptors, or lysosome). Furthermore, several integrated topics linking cell death to metabolism, redox status, transcription regulation are included and a systems biology approach to study apoptosis is introduced. Moreover, the roles of apoptosis and cell death in the pathogenesis of many human diseases in every major organ system are explored in detail with a novel therapeuticoutlook. This edition is the result of the hard work by more than 80 leading experts from across the world.

Authoritative, comprehensive and highly instructive, the second edition of Essentials of Apoptosis should be valuable for both novice and seasoned investigator, as an informative reference as well as a practical guide.

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Editorial Reviews

From the Publisher

From the reviews of the second edition:

"This book comprehensively reviews knowledge of the main mechanism of cell death, apoptosis, both from the molecular viewpoint and in relation to the roles of this process in mammalian physiology and pathology. … chapters are well written and scholarly in content and present the reader with a thorough and up-to-date insight into these fields. This book is highly recommended for scientists working in many areas of cell or developmental biology, as well as those involved in more clinical fields, such as neurobiology or molecular oncology." (Mike Clemens, Microbiology Today, November, 2009)

“The book ‘Essentials of Apoptosis’ is a collection of 31 review articles, covering a wide variety of approaches in studying cell death. … It enables the reader to get acquainted with many aspects of apoptosis, and impressive amounts of references cited in each of the article allows for further studies on the subject. I recommend this book to anyone seriously interested in research on programmed dell death.” (Piotr P. Stepien, Acta Biochimica Polonica, December, 2010)

“Prof. Yin and Prof. Dong … were able to cover both conceptual and practical aspects as well as both basic and applied research aspects, thus leading to translation research aspects in biomedicine, which is a crucial hot topic in modern biomedical clinic. … the potential readership is made up of the entire scientific comunity … and cellular biologists, developmental biologists, protein scientists.” (CarloAlberto Redi, European Journal of Hishemistry, Vol. 54 (e11), 2010)

“Comprehensive overview of the history and current knowledge of the study of the genetic program of cell death … . the book is to inform the basic researcher and the clinician interested in understanding how inappropriate apoptosis may underlie their area of scientific interest, and in this respect it succeeds. … a welcome addition for the collection of a newcomer to apoptosis: in the basic research lab, a graduate student or post-doc would benefit from … the excellent reference sections provided for each chapter.” (Robert Screaton, The Canadian Journal of Neurological Science, May, 2010)

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Product Details

  • ISBN-13: 9781588291462
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 2/28/2003
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 272
  • Product dimensions: 10.00 (w) x 7.00 (h) x 0.80 (d)

Table of Contents

Part I Molecules and Pathways of Apoptosis

1 Caspases: Activation, Regulation, and Function Stefan J. Riedl Fiona L. Scott 3

2 The Bcl-2 Family Proteins Wen-Xing Ding Xiao-Ming Yin 25

3 The Mammalian IAPs: Multifaceted Inhibitors of Apoptosis Eric C. LaCasse Herman H. Cheung Allison M. Hunter Stephanie Plenchette Douglas J. Mahoney Robert G. Korneluk 63

4 Structural Biology of Programmed Cell Death Yigong Shi 95

5 The Death Receptor Pathway Maria Eugenia Guicciardi Gregory J. Gores 119

6 The Mitochondrial Pathway: Focus on Shape Changes Silvia Campello Luca Scorrano 151

7 The Endoplasmic Reticulum Pathway Michael W. Harr Clark W. Distelhorst 177

8 Reactive Oxygen Species in Cell Fate Decisions Han-Ming Shen Shazib Pervaiz 199

9 The Integration of Metabolism and Cell Death Jonathan L. Coloff Yuxing Zhao Jeffrey C. Rathmell 223

10 Transcriptional Regulation of Apoptosis Crissy Dudgeon Wei Qiu Quanhong Sun Lin Zhang Jian Yu 239

11 Clearance of Apoptotic Cells - Mechanisms and Consequences Carylyn J. Marek Lars-Peter Erwig 261

12 Systems Biology Approaches to the Study of Apoptosis Heinrich Huber Eric Bullinger Markus Rehm 283

Part II Apoptosis in Model Organisms

13 Programmed Cell Death in Plants: Apoptotic but Not Quite Naohide Watanabe Eric Lam 301

14 Tracing the Roots of Death: Apoptosis in Saccharomyces cerevisiae Didac Carmona-Gutierrez Frank Madeo 325

15 Programmed Cell Death in C. elegans Monica Darland-Ransom Yi-Chun Wu Ding Xue 355

16 Cell Death in Drosophila Dianne C. Purves Jessica P. Monserrate Carrie Baker Brachmann 375

Part III Apoptosis in Mammalian Physiology and Pathogenesis

17 Cell Death: Defining and MisshapingMammalian Embryos Zahra Zakeri Richard A. Lockshin 409

18 Matters of Life and Death in the Immune System Christopher P. Dillon Douglas R. Green 423

19 Cell Death in the Hematopoietic System Emma C. Josefsson Benjamin T. Kile 443

20 Cell Death in Acute Neuronal Injury R. Anne Stetler Armando P. Signore Jun Chen 461

21 Apoptosis in Neurodegenerative Diseases Qiuli Liang Jianhua Zhang 479

22 Apoptosis in Cardiovascular Pathogenesis Hamid el Azzouzi Meriem Bourajjaj Paula A. da Costa Martins Leon J. De Windt 505

23 Apoptosis in Lung Injury and Disease Stefan W. Ryter Hong Pyo Kim Augustine M. K. Choi 523

24 Apoptosis in Liver Injury and Liver Diseases Yosuke Osawa Ekihiro Seki David A. Brenner 547

25 Apoptosis in Acute Kidney Injury Navjotsingh Pabla Qingqing Wei Zheng Dong 565

26 Apoptosis in Cancer Biology and Cancer Therapeutics Simone Fulda 581

Part IV Alternative Cell Death Mechanisms and Pathways

27 Necrosis: Molecular Mechanisms and Physiological Roles Linde Duprez Nele Vanlangenakker Nele Festjens Franky Van Herreweghe Tom Vanden Berghe Peter Vandenabeele 599

28 Caspase-Independent Mitotic Death Katsumi Kitagawa 635

29 Lysosomal Proteases in Cell Death Nathalie Andrieu-Abadie 647

30 Autophagy and Cell Death Wentao Gao Jeong-Han Kang Yong Liao Min Li Xiao-Ming Yin 671

Part V Approaches to the Study of Apoptosis

31 Analysis of Apoptosis: Basic Principles and Protocols Man Jiang Craig Brooks Guie Dong Xiaoning Li Hong-Min Ni Xiao-Ming Yin Zheng Dong 691

Index 713

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