The Essentials of Biostatistics for Physicians, Nurses, and Clinicians / Edition 1

Paperback (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $54.99
Usually ships in 1-2 business days
(Save 34%)
Other sellers (Paperback)
  • All (9) from $54.99   
  • New (7) from $58.80   
  • Used (2) from $54.99   


Many universities, hospitals, and medical research facilities offer short courses in introductory biostatistics for the clinicians, fellows, nurses, and health practitioners to become familiarized with statistical methods. Written in a concise, clear, and straight-to-the-point style, this book begins with a basic introduction to the relationship between biostatistics and medical research. Subsequent chapters explore numerical techniques, including sampling from populations, graphics and summary statistics, normal distribution and related properties, estimating means and proportions, hypothesis testing, correlation, regression, diagnostics, logistic regression, contingency tables, nonparametric methods, and survival analysis.

Read More Show Less

Editorial Reviews

From the Publisher
"This book should be very useful for its intended readers, but it would be helpful if they had a beginning understanding of basic statistics and terminology." (Doody's, 10 February 2012)
Doody's Review Service
Reviewer: Diane M Tomasic, EdD, RN (Slippery Rock University )
Description: This book presents a nontechnical approach to the essential biostatics used in medical research, covering topics not necessarily taught in traditional introductory statistics courses, explaining them on a conceptual level without the theoretical background or how they work mathematically.
Purpose: The purpose is to provide readers with the knowledge they need to understand biostatics and their application in medical research. The emphasis is on how to interpret biostatistics and incorporate medical research into practice.
Audience: The target audience is nurses and physicians, hospital residents, and fellows. The author recommends this book as a supplement for biostatics courses at the upper-undergraduate and graduate levels. It also can serve as a resource for healthcare professionals. The author, who has over 30 years in the field of biostatics, teaches biostatistics and has published a book on the subject.
Features: A basic introduction to the relationship between biostatics and medical research begins the book. The significance of statistical methods in medical literature and clinical trials research is explored. Key concepts covered include correlation, regression, and logistic regression, diagnostics, estimating means and proportions, normal distribution and the central limit theorem, sampling from populations, contingency tables, meta-analysis, nonparametric methods, survival analysis, repeated measures analysis of variance, hazard ratios, contingency tables, log rank tests, bioequivalence, crossover designs, selection bias, and group sequential method. Chapter exercises test for comprehension.
Assessment: This book should be very useful for its intended readers, but it would be helpful if they had a beginning understanding of basic statistics and terminology.
Read More Show Less

Product Details

  • ISBN-13: 9780470641859
  • Publisher: Wiley
  • Publication date: 9/27/2011
  • Series: Wiley Desktop Editions Series
  • Edition number: 1
  • Pages: 228
  • Sales rank: 1,262,882
  • Product dimensions: 6.10 (w) x 9.20 (h) x 0.60 (d)

Meet the Author

Michael R. Chernick, PhD, is Manager of Biostatistical Services at Lankenau Institute for Medical Research, where he conducts statistical design and analysis for pharmaceutical research. He has more than thirty years of experience in the application of statistical methods to such areas as medicine, energy, engineering, insurance, and pharmaceuticals. Dr. Chernick is the author of Bootstrap Methods: A Guide for Practitioners and Researchers, Second Edition, and the coauthor of Introductory Biostatistics for the Health Sciences: Modern Applications Including Bootstrap, both published by Wiley.

Read More Show Less

Table of Contents

Preface ix

1. The What, Why, and How of Biostatistics in Medical Research 1

1.1 Defi nition of Statistics and Biostatistics, 1

1.2 Why Study Statistics?, 3

1.3 The Medical Literature, 9

1.4 Medical Research Studies, 11

1.4.1 Cross-sectional studies including surveys, 11

1.4.2 Retrospective studies, 12

1.4.3 Prospective studies other than clinical trials, 12

1.4.4 Controlled clinical trials, 12

1.4.5 Conclusions, 13

1.5 Exercises, 14

2. Sampling from Populations 15

2.1 Definitions of Populations and Samples, 17

2.2 Simple Random Sampling, 18

2.3 Selecting Simple Random Samples, 19

2.4 Other Sampling Methods, 27

2.5 Generating Bootstrap Samples, 28

2.6 Exercises, 32

3. Graphics and Summary Statistics 34

3.1 Continuous and Discrete Data, 34

3.2 Categorical Data, 35

3.3 Frequency Histograms, 35

3.4 Stem-and-Leaf Diagrams, 38

3.5 Box Plots, 39

3.6 Bar and Pie Charts, 39

3.7 Measures of the Center of a Distribution, 42

3.8 Measures of Dispersion, 46

3.9 Exercises, 50

4. Normal Distribution and Related Properties 51

4.1 Averages and the Central Limit Theorem, 51

4.2 Standard Error of the Mean, 53

4.3 Student's t-Distribution, 53

4.4 Exercises, 55

5. Estimating Means and Proportions 58

5.1 The Binomial and Poisson Distributions, 58

5.2 Point Estimates, 59

5.3 Confi dence Intervals, 62

5.4 Sample Size Determination, 65

5.5 Bootstrap Principle and Bootstrap Confidence Intervals, 66

5.6 Exercises, 69

6. Hypothesis Testing 72

6.1 Type I and Type II Errors, 73

6.2 One-Tailed and Two-Tailed Tests, 74

6.3 P-Values, 74

6.4 Comparing Means from Two Independent Samples: Two-Sample t-Test, 75

6.5 Paired t-Test, 76

6.6 Testing a Single Binomial Proportion, 78

6.7 Relationship Between Confi dence Intervals and Hypothesis Tests, 79

6.8 Sample Size Determination, 80

6.9 Bootstrap Tests, 81

6.10 Medical Diagnosis: Sensitivity and Specificity, 82

6.11 Special Tests in Clinical Research, 83

6.11.1 Superiority tests, 84

6.11.2 Equivalence and bioequivalence, 84

6.11.3 Noninferiority tests, 86

6.12 Repeated Measures Analysis of Variance and Longitudinal Data Analysis, 86

6.13 Meta-Analysis, 88

6.14 Exercises, 92

7. Correlation, Regression, and Logistic Regression 95

7.1 Relationship Between Two Variables and the Scatter Plot, 96

7.2 Pearson's Correlation, 99

7.3 Simple Linear Regression and Least Squares Estimation, 101

7.4 Sensitivity to Outliers and Robust Regression, 104

7.5 Multiple Regression, 111

7.6 Logistic Regression, 117

7.7 Exercises, 122

8. Contingency Tables 127

8.1 2 x 2 Tables and Chi-Square, 127

8.2 Simpson's Paradox in the 2 x 2 Table, 129

8.3 The General R x C Table, 132

8.4 Fisher's Exact Test, 133

8.5 Correlated Proportions and McNemar's Test, 136

8.6 Relative Risk and Odds Ratio, 138

8.7 Exercises, 141

9. Nonparametric Methods 145

9.1 Ranking Data, 146

9.2 Wilcoxon Rank-Sum Test, 146

9.3 Sign Test, 149

9.4 Spearman's Rank-Order Correlation Coefficient, 150

9.5 Insensitivity of Rank Tests to Outliers, 153

9.6 Exercises, 154

10. Survival Analysis 158

10.1 Time-to-Event Data and Right Censoring, 159

10.2 Life Tables, 160

10.3 Kaplan–Meier Curves, 164

10.3.1 The Kaplan-Meier curve: a nonparametric estimate of survival, 164

10.3.2 Confidence intervals for the Kaplan-Meier estimate, 165

10.3.3 The logrank and chi-square tests: comparing two or more survival curves, 166

10.4 Parametric Survival Curves, 168

10.4.1 Negative exponential survival distributions, 168

10.4.2 Weibull family of survival distributions, 169

10.5 Cox Proportional Hazard Models, 170

10.6 Cure Rate Models, 171

10.7 Exercises, 173

Solutions to Selected Exercises 175

Appendix: Statistical Tables 192

References 204

Author Index 209

Subject Index 211

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)