Estrogens and Progestogens in Clinical Practice / Edition 1

Estrogens and Progestogens in Clinical Practice / Edition 1

by Ian S. Fraser
     
 

ISBN-10: 0443047065

ISBN-13: 9780443047060

Pub. Date: 02/10/1999

Publisher: Elsevier Health Sciences

This book provides a comprehensive approach to an understanding of all clinical conditions where estrogens and progestogens are involved. It encompasses the underlying science of chemistry, physiology, biochemistry and pharmacology. There is a broad but detailed perspective on the clinical use of estrogens and progestogens in therapy, contraception and hormone

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Overview

This book provides a comprehensive approach to an understanding of all clinical conditions where estrogens and progestogens are involved. It encompasses the underlying science of chemistry, physiology, biochemistry and pharmacology. There is a broad but detailed perspective on the clinical use of estrogens and progestogens in therapy, contraception and hormone replacement therapy. An international line up of contributors provide an up-to-date world view on this subject.

Product Details

ISBN-13:
9780443047060
Publisher:
Elsevier Health Sciences
Publication date:
02/10/1999
Edition description:
New Edition
Pages:
928
Product dimensions:
7.70(w) x 9.90(h) x 1.90(d)

Table of Contents

Sect. 1Historical overview
1Discovery of the physiological roles of estrogen and progesterone3
2Historical overview of estrogens and progestogens as therapeutic agents13
3Drug regulatory testing19
Sect. 2Chemistry
4Structure-function relationships and metabolism of estrogens and progestogens27
5Chemistry of antihormones41
6Chemical synthesis55
Sect. 3Physiology
7Biosynthesis and secretion of ovarian and adrenal steroids73
8Metabolism of estrogens and progestogens89
9Feedback mechanisms95
10The normal menstrual cycle; changes throughout life105
11Actions of estrogens and progesterone at the cellular level119
12The molecular basis for the development of estrogen and progesterone agonists and antagonists135
13Effects of estrogen and progesterone on the endometrium145
14Menstruation163
15Effects of estrogen and progesterone on myometrium, cervix, fallopian tube, vagina and vulva173
16Effects of estrogen and progesterone on the breast187
17Effects of estrogen and progesterone on the central nervous system195
18Effects of estrogen and progesterone on bone205
19Vascular effects of estrogen and progesterone215
20Effects of estrogen and progesterone on the urinary tract, rectum and pelvic floor225
21Effects of estrogen and progesterone on skin233
22Estrogen and progesterone during pregnancy and parturition243
23Estrogens and progesterone in the postpartum period255
24Estrogens and progesterone in the fetus and neonate265
Sect. 4Pharmacology
25Pharmacokinetics of estrogens and progestogens273
26Pharmacodynamic effects of estrogens and progestogens295
27The pharmacology of antiestrogens and antiprogestogens307
Sect. 5Laboratory assessment
28Assays for estrogens and progestogens321
29Imaging of the pelvic organs339
Sect. 6Therapeutics
30Primary and secondary amenorrhea357
31Primary dysmenorrhea365
32Secondary dysmenorrhea and chronic pelvic pain373
33Premenstrual syndrome387
34Polycystic ovarian syndrome (PCOS)405
35Dysfunctional uterine bleeding419
36Defective luteal function437
37Endometriosis and adenomyosis455
38Leiomyomata471
39The pathophysiology and therapy of benign breast disease487
40Precocious puberty495
41Assisted reproductive technologies507
42Use of therapeutic steroids in pregnancy521
43Fetal effects of progestogens and diethylstilbestrol533
44Clinical aspects of oral contraception555
45Clinical aspects of the use of long-acting hormonal contraception579
46Antiprogestogens for contraception, interception and medical termination of pregnancy603
47Demographic aspects of menopause617
48Pituitary and ovarian changes627
49Hot flashes635
50Psychological effects of menopause647
51Pharmacological background of estrogen replacement therapy and continuance655
52General principles of administration of hormone replacement therapy: indications and contraindications, routes of administration, treatment schedules667
53Benefits of treatment: local and general menopausal symptoms687
54Benefits of treatment: osteoporosis699
55Effects of hormone replacement therapy on the cardiovascular system711
56Progestogen therapy in malignant tumors of the uterus and ovary727
57Use of estrogens and progestogens in women with breast cancer737
58Sex steroid production from ovarian tumors745
59An overview of side effects751
60Non-therapeutic beneficial effects763
61Effects on carbohydrate metabolism773
62Effects of estrogens and progestogens on plasma lipids and lipoproteins787
63Effects on the immunological system799
64Psychological, mood and central nervous system effects805
65Psychosexual effects817
66Effects on other tissues825
67The influence of therapeutic steroids on gynecologic cancers831
68Influence of therapeutic steroids on the incidence and severity of breast cancer865
Index879

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