Estrogens and Progestogens in Clinical Practice / Edition 1

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This book provides a comprehensive approach to an understanding of all clinical conditions where estrogens and progestogens are involved. It encompasses the underlying science of chemistry, physiology, biochemistry and pharmacology. There is a broad but detailed perspective on the clinical use of estrogens and progestogens in therapy, contraception and hormone replacement therapy. An international line up of contributors provide an up-to-date world view on this subject.

The book contains black-and-white illustrations.

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Product Details

  • ISBN-13: 9780443047060
  • Publisher: Elsevier Health Sciences
  • Publication date: 2/10/1999
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 928
  • Product dimensions: 7.70 (w) x 9.90 (h) x 1.90 (d)

Meet the Author

Dr. Lobo, formerly Rappleye Professor and Chair of the Department of Obstetrics and Gynecology, and Director of the Center for Reproductive Sciences, Columbia University, has done extensive research in various areas of reproductive endocrinology and infertility including estrogen metabolism and menopause. Dr. Lobo has a primary interest in hyperandrogenic disorders and polycystic ovary syndrome. He frequently serves as editor for peer-review journals and has authored over 300 articles and 16 books.

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Table of Contents

Sect. 1 Historical overview
1 Discovery of the physiological roles of estrogen and progesterone 3
2 Historical overview of estrogens and progestogens as therapeutic agents 13
3 Drug regulatory testing 19
Sect. 2 Chemistry
4 Structure-function relationships and metabolism of estrogens and progestogens 27
5 Chemistry of antihormones 41
6 Chemical synthesis 55
Sect. 3 Physiology
7 Biosynthesis and secretion of ovarian and adrenal steroids 73
8 Metabolism of estrogens and progestogens 89
9 Feedback mechanisms 95
10 The normal menstrual cycle; changes throughout life 105
11 Actions of estrogens and progesterone at the cellular level 119
12 The molecular basis for the development of estrogen and progesterone agonists and antagonists 135
13 Effects of estrogen and progesterone on the endometrium 145
14 Menstruation 163
15 Effects of estrogen and progesterone on myometrium, cervix, fallopian tube, vagina and vulva 173
16 Effects of estrogen and progesterone on the breast 187
17 Effects of estrogen and progesterone on the central nervous system 195
18 Effects of estrogen and progesterone on bone 205
19 Vascular effects of estrogen and progesterone 215
20 Effects of estrogen and progesterone on the urinary tract, rectum and pelvic floor 225
21 Effects of estrogen and progesterone on skin 233
22 Estrogen and progesterone during pregnancy and parturition 243
23 Estrogens and progesterone in the postpartum period 255
24 Estrogens and progesterone in the fetus and neonate 265
Sect. 4 Pharmacology
25 Pharmacokinetics of estrogens and progestogens 273
26 Pharmacodynamic effects of estrogens and progestogens 295
27 The pharmacology of antiestrogens and antiprogestogens 307
Sect. 5 Laboratory assessment
28 Assays for estrogens and progestogens 321
29 Imaging of the pelvic organs 339
Sect. 6 Therapeutics
30 Primary and secondary amenorrhea 357
31 Primary dysmenorrhea 365
32 Secondary dysmenorrhea and chronic pelvic pain 373
33 Premenstrual syndrome 387
34 Polycystic ovarian syndrome PCOS 405
35 Dysfunctional uterine bleeding 419
36 Defective luteal function 437
37 Endometriosis and adenomyosis 455
38 Leiomyomata 471
39 The pathophysiology and therapy of benign breast disease 487
40 Precocious puberty 495
41 Assisted reproductive technologies 507
42 Use of therapeutic steroids in pregnancy 521
43 Fetal effects of progestogens and diethylstilbestrol 533
44 Clinical aspects of oral contraception 555
45 Clinical aspects of the use of long-acting hormonal contraception 579
46 Antiprogestogens for contraception, interception and medical termination of pregnancy 603
47 Demographic aspects of menopause 617
48 Pituitary and ovarian changes 627
49 Hot flashes 635
50 Psychological effects of menopause 647
51 Pharmacological background of estrogen replacement therapy and continuance 655
52 General principles of administration of hormone replacement therapy: indications and contraindications, routes of administration, treatment schedules 667
53 Benefits of treatment: local and general menopausal symptoms 687
54 Benefits of treatment: osteoporosis 699
55 Effects of hormone replacement therapy on the cardiovascular system 711
56 Progestogen therapy in malignant tumors of the uterus and ovary 727
57 Use of estrogens and progestogens in women with breast cancer 737
58 Sex steroid production from ovarian tumors 745
59 An overview of side effects 751
60 Non-therapeutic beneficial effects 763
61 Effects on carbohydrate metabolism 773
62 Effects of estrogens and progestogens on plasma lipids and lipoproteins 787
63 Effects on the immunological system 799
64 Psychological, mood and central nervous system effects 805
65 Psychosexual effects 817
66 Effects on other tissues 825
67 The influence of therapeutic steroids on gynecologic cancers 831
68 Influence of therapeutic steroids on the incidence and severity of breast cancer 865
Index 879
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