Etiology of Breast and Gynecological Cancers / Edition 1

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Overview

Progress in Clinical and Biological Research, Volume 396 Etiology of Breast and Gynecological Cancers Proceedings of the Ninth International Conference on Carcinogenesis and Risk Assessment, Held in Austin, Texas, November 29-December 2, 1995 C. Marcelo Aldaz, Michael N. Gould, John McLachlan, and Thomas J. Slaga, Editors Accounting for 150 cancers per 100,000 people at risk, breast cancer and gynecological cancer together constitute a major public health concern. These cancers have a common target population, and many also have common etiological features, including hormonal factors, genetic changes in genes such as BRCA1, and environmental factors such as ionizing radiation, viruses, chemical xenobiotics, diet, and nutrition. Etiology of Breast and Gynecological Cancers explores important environmental and genetic factors that are key to the induction of these cancers. The book takes a broad perspective, with chapters contributed by laboratory investigators and clinicians, as well as by epidemiologists. It emphasizes validation and issues of extrapolation from animal models to humans and their impact on risk assessment, and it also discusses intervention strategies in terms of chemoprevention, which has the potential to reduce the morbidity and mortality from these cancers in women. Etiology of Breast and Gynecological Cancers explores a wide variety of topics, including:
* recent advances in the molecular genetics of hereditary breast and ovarian cancer
* molecular perspectives on cancer, the cell cycle, and the inherited disorder ataxia-telangiectasia
* genotoxicity of environmental agents in human mammary epithelial cells
* rodent model of reproductive tract leiomyomata
* estrogens and the genetic control of tumor growth
Featuring 19 outstanding presentations from leading researchers in an array of disciplines, Etiology of Breast and Gynecological Cancers is an important resource for investigators and clinicians in oncology, epidemiology, and public health, providing new understanding of the sources of these disorders as well as new directions for treatment and prevention.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Jennifer I. MacGregor(Northwestern University Feinberg School of Medicine)
Description: This book provides a summary of the Ninth International Conference on Carcinogenesis and Risk Assessment, "Etiology of Breast and Gynecologic Cancers." It offers a broad perspective of environmental and genetic factors that play a role in the induction of breast and gynecologic cancers and a discussion of laboratory and clinical investigations.
Purpose: The purpose is to provide information about important issues in the development of breast and gynecologic cancers. This is a worthy objective because the field is growing so rapidly and becoming so complex that an overview on the etiology of gynecologic cancers is a necessary resource. This book contains an excellent survey of the most pertinent topics in gynecologic cancer etiology, research, and treatment.
Audience: The audience targeted by this book consists of investigators and clinicians in the fields of oncology, epidemiology, and public health. This is appropriate because the book is comprised of 19 chapters from a number of contributors that are authorities these disciplines. In addition, this book provides a valuable learning tool for students entering this field.
Features: The quality and pertinence of the illustrations is good, although a larger quantity of illustrations would provide more dimensions to the book. The references are current and provide a good foundation for each chapter. The differences in the fonts and in the formats of the chapters is distracting. The overall appearance of the book is good, and it is well organized.
Assessment: Because there are so many different aspects of these diseases that need to be addressed, this book is a valuable resource in that it provides a detailed overview of various issues that can afford a broader understanding of this subject to the reader. This excellent book would be best received in a library or if purchased by an individual.
Jennifer I. MacGregor(Northwestern University Medi School)
This book provides a summary of the Ninth International Conference on Carcinogenesis and Risk Assessment, ""Etiology of Breast and Gynecologic Cancers."" It offers a broad perspective of environmental and genetic factors that play a role in the induction of breast and gynecologic cancers and a discussion of laboratory and clinical investigations. The purpose is to provide information about important issues in the development of breast and gynecologic cancers. This is a worthy objective because the field is growing so rapidly and becoming so complex that an overview on the etiology of gynecologic cancers is a necessary resource. This book contains an excellent survey of the most pertinent topics in gynecologic cancer etiology, research, and treatment. The audience targeted by this book consists of investigators and clinicians in the fields of oncology, epidemiology, and public health. This is appropriate because the book is comprised of 19 chapters from a number of contributors that are authorities these disciplines. In addition, this book provides a valuable learning tool for students entering this field. The quality and pertinence of the illustrations is good, although a larger quantity of illustrations would provide more dimensions to the book. The references are current and provide a good foundation for each chapter. The differences in the fonts and in the formats of the chapters is distracting. The overall appearance of the book is good, and it is well organized. Because there are so many different aspects of these diseases that need to be addressed, this book is a valuable resource in that it provides a detailed overview of various issues that can afford a broaderunderstanding of this subject to the reader. This excellent book would be best received in a library or if purchased by an individual.
Booknews
Combines two types of cancer that not only have a common target population, but share etiological features such as hormonal factors, changes in BRCA1 and other genes, and environmental risk factors. Researchers, clinicians, and epidemiologists offer 19 papers on a unified concept of mammary carcinogenesis, the molecular genetics of hereditary breast and ovarian cancer, the molecular epidemiology of breast cancer, the characterization and use in preclinical therapeutic studies of rodent models of reproductive tract leiomyomata, the metabolism and genotoxicity of tamoxifen, and other topics. Annotation c. by Book News, Inc., Portland, Or.

3 Stars from Doody
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Product Details

Table of Contents

Partial table of contents:

Toward a Unified Concept of Mammary Carcinogenesis (J. Russo & I. Russo).

Recent Advances in the Molecular Genetics of Hereditary Breast and Ovarian Cancer (J. Lancaster & R. Wiseman).

The Genetics of Sporadic Breast Cancer (A. Brenner & C. Aldaz).

Radiation and Breast Cancer Risk (C. Land).

Organochlorine Exposure and Risk for Breast Cancer (S. Safe & T. Zacharewski).

Perspectives and Progress in Development of Breast Cancer Chemopreventive Drugs (G. Kelloff, et al.).

The Molecular Genetics of Endometrial Carcinoma (C. Bandera & J. Boyd).

The Metabolism and Genotoxicity of Tamoxifen (I. White, et al.).

Tamoxifen Breast Cancer Prevention Trial—An Update (L. Ford & K. Johnson).

Index.

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