Table of Contents
List of contributors, viii
Preface to the third edition, xiv
Classification of recommendations and levels of evidence, xvi
List of abbreviations, xvii
Part I: General concepts and critical appraisal
Salim Yusuf, Editor
1 Evidence-based decision making: patient–physician interface, 3
Philip J Devereaux, Marc Pfeffer, Salim Yusuf
2 Obtaining incremental information from diagnostic tests, 14
Raymond J Gibbons
3 Clinical trials and meta-analysis, 26
Jonathan R Emberson, Colin Baigent
4 Understanding concepts related to health economics, 38
Mark A Hlatky
5 Major vascular complications in patients undergoing non-cardiac surgery: magnitude of the problem, risk prediction, surveillance, and prevention, 47
Philip J Devereaux, Matthew Chan, John Eikelboom
6 Implementing evidence-based medicine in cardiology, 63
Brahmajee K Nallamothu, Thomas T Tsai, Jack V Tu
7 The application of evidence-based medicine to employment fitness standards: the transportation industries with special reference to aviation, 79
Michael Joy
Part II: Prevention of cardiovascular diseases
Salim Yusuf and John A Cairns, Editors
8 Global perspective on cardiovascular disease, 95
K Srinath Reddy
9 Avoidance of worldwide vascular deaths and total deaths from smoking, 111
Prabhat Jha, Prem Mony, James Moore, Witold Zatonski
10 Tobacco and cardiovascular disease: achieving smoking cessation in cardiac patients, 125
Andrew Pipe
11 Lipids and cardiovascular disease, 138
Malcolm Law
12 Use of lipid-lowering agents in the prevention of cardiovascular disease, 147
R Alan Failor, Jeffrey L Probstfi eld
13 Blood pressure and cardiovascular disease, 165
Curt D Furberg, Bruce M Psaty, Elsayed Z Soliman
14 Dysglycemia and the risk of cardiovascular events, 179
Hertzel C Gerstein, Zubin Punthakee
15 Physical activity and exercise in cardiovascular disease prevention and rehabilitation, 190
Ray W Squires
16 Psychosocial factors, 201
Annika Rosengren
17 The social determinants of cardiovascular disease, 211
Martin McKee, Clara K Chow
18 Obesity, 221
Raj S Padwal, Arya M Sharma
19 Ethnicity and cardiovascular disease, 235
Clara K Chow, Sonia S Anand, Salim Yusuf
20 Fetal origins of coronary artery disease, 258
Katherine M Morrison, Stephanie Atkinson, Koon K Teo
21 Genetics of coronary heart disease, 268
Michael S Cunnington, Bernard D Keavney
22 Molecular genetics of cardiovascular disorders, 288
Ali J Marian, Robert Roberts
23 Diet and cardiovascular disease, 304
K Srinath Reddy
24 Integrating approaches to prevention of cardiovascular disease, 328
David A Wood, Kornelia Kotseva
Part IIIa: Stable coronary artery disease
John A Cairns and Bernard J Gersh, Editors
25 Medical management of stable coronary artery disease, 345
William E Boden
26 Percutaneous intervention, 357
David A Wood, Rohit Khurana, Christopher E Buller
27 Surgical coronary artery revascularization, 379
Morgan L Brown, Thoralf M Sundt III
28 Comparisons of percutaneous coronary intervention and coronary artery bypass grafting, 392
Arashk Motiei, Thoralf M Sundt III, Charanjit S Rihal
Part IIIb: Acute coronary syndromes
John A Cairns and Bernard J Gersh, Editors
29 Non-ST segment elevation acute coronary syndromes: unstable angina and non-ST segment elevation myocardial infarction, 409
Pierre Theroux, John A Cairns
30 Early prehospital management of ST segment elevation myocardial infarction, 444
Robert C Welsh, Paul W Armstrong
31 Reperfusion therapies for ST segment elevation myocardial infarction, 456
Joseph B Muhlestein, Jeffrey L Anderson
32 Antithrombotic therapies for patients with ST segment elevation myocardial infarction, 475
Andrew J Lucking, Keith A A Fox
33 Complications after myocardial infarction, 495
Peter L Thompson
34 An integrated approach to the management of patients after the early phase of ST segment elevation myocardial infarction, 516
Pedro L Sánchez, Francisco Fernández- Avilés
Part IIIc: Arrhythmias
A John Camm and John A Cairns, Editors
35 Atrial fibrillation: rhythm and rate control therapies, 531
Irina Savelieva, Albert L Waldo, A John Camm
36 Atrial fi brillation: upstream therapies, 568
Antonios Kourliouros, Irina Savelieva, Marjan Jahangiri, A John Camm
37 Atrial fibrillation: antithrombotic therapy, 581
John A Cairns, Stuart Connolly
38 Ablation therapy for atrial fi brillation, 596
Conor D Barrett, Chi Keong Ching, Luigi Di Biase, Claude S Elayi, David J Burkhardt, Rodney Horton, Andrea Natale
39 Supraventricular tachycardia, 606
Erica D Penny-Peterson, Gerald V Naccarelli
40 Prevention and treatment of life-threatening ventricular arrhythmia and sudden death, 619
Carlos A Morillo, Adrian Baranchuk
41 Pacemaker therapy, including cardiac resynchronization therapy, 636
William D Toff, A John Camm
42 Syncope, 673
David G Benditt, Fei Lu, Scott Sakaguchi
43 Cardiopulmonary resuscitation, 692
Michael Colquhoun
44 Arrhythmias due to monogenic disorders, 706
Dawood Darbar, Prince Kannankeril, Dan M L Roden
45 Arrhythmiagenic right ventricular cardiomyopathy, 721
Deirdre Ward, Perry M Elliott
Part IIId: Specifi c cardiovascular disorders: left ventricular dysfunction
Salim Yusuf, Editor
46 Epidemiology and prevention of heart failure and management of asymptomatic left ventricular systolic dysfunction, 735
J Paul Rocchiccioli, John J V McMurray
47 Management of overt heart failure, 756
Paul J Hauptman, Karl Swedberg
48 Acute myocarditis and dilated cardiomyopathy, 784
Leslie T Cooper Jr, Oyere K Onuma
49 Management of hypertrophic cardiomyopathy, 796
Barry J Maron
50 Infective and infi ltrative cardiomyopathies, 808
Stavros Kounas, Perry M Elliott
51 Chagas’ heart disease, 823
J Antonio Marin-Neto, Anis Rassi Jr, Benedito Carlos Maciel, Marcus Vinicius Simões, André Schmidt
Part IIIe: Specifi c cardiovascular disorders: pericardial disease
Bernard J Gersh, Editor
52 Pericardial disease: an evidence-based approach to clinical management, 845
Faisal F Syed, Bongani M Mayosi
Part IIIf: Specifi c cardiovascular disorders: valvular heart disease
Bernard J Gersh, Editor
53 Rheumatic heart disease: prevention and acute treatment, 861
Bongani M Mayosi, Patrick J Commerford
54 Mitral valve disease: indications for surgery, 869
Blase A Carabello
55 Surgical indications in aortic valve disease, 878
Sunil Mankad, Heidi M Connolly, Shahbudin H Rahimtoola
56 Non-surgical aortic valve therapy: balloon valvuloplasty and transcatheter aortic valve replacement, 896
Robert H Boone, John G Webb
57 Balloon valvuloplasty: mitral valve, 913
Zoltan G Turi
58 Valve repair and choice of valve, 927
Shafie S Fazel, Tirone E David
59 Infective endocarditis, 941
Zainab Samad, Andrew Wang
60 Antithrombotic therapy after heart valve replacement, 957
Jack C J Sun, John W Eikelboom
Part IIIg: Specifi c cardiovascular disorders: other conditions
Bernard J Gersh and Salim Yusuf, Editors
61 Stroke, 971
Brian H Buck, Ashfaq Shuaib, Craig Anderson
62 Heart disease and pregnancy, 993
Rachel M Wald, Samuel C Siu
63 Adult congenital heart disease, 1006
Elisabeth Bédard, Michael A Gatzoulis
64 Venous thromboembolic disease, 1032
Lori-Ann Linkins, Clive Kearon
65 Peripheral arterial disease, 1050
Catherine McGorrian, Sonia S Anand
66 Cardiac risk in those undergoing non-cardiac surgery, 1068
Ameeth Vedre, Kim A Eagle
67 Clinical management of diseases of the aorta, 1079
Thoralf M Sundt III
68 Cardiac transplantation: indications and postoperative management, 1099
Barry Boilson, Sudhir Kushwaha
69 Renal dysfunction, 1110
Johannes F E Mann, Ernesto L Schiffrin
70 Pulmonary hypertension, 1118
Brendan P Madden
Part IV: Clinical applications
Ernest L Fallen, Editor
71 Clinical applications of external evidence, 1135
Ernest L Fallen, Salim Yusuf
72 Stable angina: choice of PCI versus CABG versus drugs, 1138
William S Weintraub
73 Non-ST segment acute coronary syndrome, 1142
David Fitchett
74 Acute ST segment elevation myocardial infarction, 1152
Ernest L Fallen
75 Secondary prevention strategies post myocardial infarction, 1157
Jacques Genest
76 Heart failure, 1164
Michael M Givertz, Garrick C Stewart
77 Atrial fibrillation, 1170
Michael Klein
78 The case for and against implantable cardioverter defibrillators in patients with coronary artery disease, 1174
Jeffrey S Healey
79 Bradyarrhythmias – choice of pacemakers, 1178
Pablo B Nery, Carlos A Morillo
80 Peripheral arterial disease with suspect coronary artery disease, 1183
Victor Aboyans, Michael H Criqui
81 Valvular heart disease: timing of surgery, 1187
Jon-David R Schwalm, Victor Chu
Index, 1191
The colour plate section can be found facing p. 941