Evidence-Based Gastroenterology and Hepatology / Edition 3

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The only evidence-based resource combining gastroenterology and hepatology, this major textbook critically appraises the evidence for diagnosis, screening, and treatment of gastrointestinal and hepatic diseases, and provides clear recommendations for management. A unique feature is the grading of both the evidence (randomized controlled trials, systematic reviews, or lower quality trials) and the treatment recommendations. This structure provides the reader with valuable guidance on implementation. The third edition has been fully revised, providing the latest reviews of the evidence. It is also enhanced with new topics that have significant evidence for treatment, including;
• Esinophilic esophagitis
• Acute dysenteries
• Prevention and treatment of travellers' diarrhoea
• Frequency of adverse drug effects on bowel function
• Management of hepatitis B
• Management of Hepatitis C
• Vascular disorder of the liver
• Non invasive diagnosis of liver fibrosis
• Drug induced liver disease

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Editorial Reviews

From the Publisher
"There is plenty of terrific material in this book. Each chapter provides information that can be used by busy clinicians to make decisions about their patients." (Gastroenterological, 1 March 2011)

"A well written, easily consulted, updated textbook divided into 2 parts . . . written by experts from several countries. Its orientation is mainly to adult medicine." (Pediatric Endocrinology Reviews, 1 June 2011)

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Product Details

  • ISBN-13: 9781405181938
  • Publisher: Wiley
  • Publication date: 9/28/2010
  • Series: Evidence-Based Medicine Series
  • Edition number: 3
  • Pages: 824
  • Sales rank: 785,992
  • Product dimensions: 8.90 (w) x 10.80 (h) x 1.70 (d)

Meet the Author

John McDonald, Professor of Gastroenterology at the University of Ontario, London Ontario, Coordinating Editor in the Cochrane Collaboration Steering Committee on methodology, and Past President of the Canadian College of Gastroenterology

Professor Andrew Burroughs MBChB Hons FRCP
Consultant Physician and Hepatologist, Royal Free Hospital, London, has an international reputation as a clinical and academic Hepatologist and has published widely in all areas of liver disease. He is a full time clinician and has been awarded a personal chair, as Professor of Hepatology in the University of London.

Brian Feagan is Professor of Medicine and Epidemiology and Biostatistics at the University of Western Ontario. He holds cross-appointments in the Divisions of Internal Medicine, Clinical Pharmacology and Gastroenterology. He is a specialist in Internal Medicine with training in Clinical Epidemiology and Gastroenterology who has been the lead investigator in the design and implementation of randomized controlled trials since 1986. In addition to being an internationally recognized expert in the therapy of Inflammatory Bowel Disease, Dr. Feagan has conducted trials on behalf of Industry and peer-reviewed agencies in a wide range of disease states. Dr. Feagan is interested in the evaluation of Health Related Quality of Life (HRQL) and has performed research on the operating properties of HRQL instruments.

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Table of Contents


1 Introduction M Brian Fennerty Fennerty, M Brian 1

Part I Gastrointestinal disorders

2 Gastroesophageal reflux disease M Brian Fennerty Fennerty, M Brian 19

3 Barrett's esophagus Carlo A Fallone A Fallone, Carlo 62

4 Esophageal motility disorders: Achalasia and spastic motor disorders Joel E Richter Richter, Joel E 78

5 Eosinophilic esophagitis Elizabeth J Elliott Elliott, Elizabeth J 93

6 Ulcer disease and Helicobacter pylori infection: Etiology and treatment Naoki Chiba Chiba, Naoki 102

7 Non-steroidal anti-inflammatory drug-induced gastro-duodenal toxicity George Wells Wells, George 139

8 Acute non-variceal gastrointestinal hemorrhage: Treatment Kelvin Palmer Palmer, Kelvin 165

9 Functional dyspepsia Sander Veldhuyzen van Zanten van Zanten, Sander Veldhuyzen 190

10 Celiac disease: Diagnosis, treatment and prognosis Michael Sai Lai Sey Sey, Michael Sai Lai 200

11 Crohn's disease John WD McDonald McDonald, John WD 211

12 Ulcerative colitis Brian G Feagan Feagan, Brian G 232

13 Pouchitis after restorative proctocolectomy William J Sandborn Sandborn, William J 248

14 Microscopic colitis: Collagenous and lymphocytic colitis Curt Tysk Tysk, Curt 257

15 Drug-induced diarrhea Joseph H Sellin Sellin, Joseph H 267

16 Metabolic bone disease in gastrointestinal disorders John WD McDonald McDonald, John WD 280

17 Colorectal cancer in ulcerative colitis: Surveillance Alastair JM Watson Watson, Alastair JM 301

18 Colorectal cancer: Population screening and surveillance Linda Rabeneck Rabeneck, Linda 311

19 Prevention and treatment of travelers' diarrhea Herbert L DuPont DuPont, Herbert L 324

20 Clostridium difficile associated disease: Diagnosis and treatment Christina M Surawiez Surawiez, Christina M 335

21 Irritable bowel syndrome Nicholas J Talley Talley, Nicholas J 355

22 Ogilvie's syndrome Michael D Saunders Saunders, Michael D 377

23 Gallstone disease Ved R Tandan Tandan, Ved R 385

24 Acute pancreatitis Hassan Elberm Elberm, Hassan 396

25 Obesity management: Considerations for the gastroenterologist Arya M Sharma Sharma, Arya M 415

Part II Liver disease

26 Hepatitis C John G McHutchison McHutchison, John G 437

27 Hepatitis B: Prognosis and treatment Antonio Craxi Craxi, Antonio 448

28 Alcoholic liver disease Philippe Mathurin Mathurin, Philippe 465

29 Non-alcoholic fatty liver disease Christopher P Day Day, Christopher P 475

30 Hemochromatosis Paul C Adams Adams, Paul C 484

31 Wilson's disease Aftab Ala Ala, Aftab 493

32 Primary biliary cirrhosis E Jenny Heathcote E, Jenny Heathcote 508

33 Autoimmune hepatitis Arndt Vogel Vogel, Arndt 524

34 Primary sclerosing cholangitis Roger W Chapman Chapman, Roger W 533

35 Non-histological assessment of liver fibrosis Marika Simon-Rudler Simon-Rudler, Marika 554

36 Portal hypertensive bleeding Andrew K Burroughs Burroughs, Andrew K 562

37 Hepatic outflow syndromes and splanchnic venous thrombosis Stephen Caldwell Caldwell, Stephen 603

38 Ascites, hepatorenal syndrome and spontaneous bacterial peritonitis Juan Rodes Rodes, Juan 619

39 Hepatic encephalopathy: Treatment Christian Muller Muller, Christian 636

40 Hepatocellular carcinoma Massimo Iavarone Iavarone, Massimo 650

41 Fulminant hepatic failure: Treatment Julia Wendon Wendon, Julia 661

42 Liver transplantation: Prevention and treatment of rejection Andrew K Burroughs Burroughs, Andrew K 685

43 Liver transplantation: Prevention and treatment of infection Miquel Navasa Navasa, Miquel 724

44 Management of HCV infection and liver transplantation James R Burton, Jr Burton, James R, Jr 740

45 Management of HBV infection and liver transplantation George V Papatheodoridis Papatheodoridis, George V 748

46 Liver biopsy Amar P Dhillon Dhillon, Amar P 762

47 Drug induced liver disease: Mechanisms and diagnosis M Isabel Lucena Lucena, M Isabel 771

Index 787

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