Evidence-Based Neurology: Management of Neurological Disorders / Edition 1

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A clinical textbook addressing the application of evidence to the management of neurological conditions. Edited by leading figures in the Cochrane Neurological Network, the book will comprise of a methodology section, followed by chapters discussing best management of both symptoms and specific diseases. International authors include clinical neurologists and epidemiologists to ensure an informed discussion of the evidence. Evidence-based Neurological Management provides an evidence-based approach to the management of all the major neurological conditions. This clinical textbook contains in-depth systematic reviews of the best evidence in the field and features leading neurologists from the Cochrane Collaboration as its editors. This essential text is also available in an electronic version, and is kept up-to-date via its website. In Evidence-based Neurology: Management of Neurological Disorders, a carefully selected group of clinically experienced collaborators use the best available evidence to answer more than 100 clinical questions about the treatment and management of neurological disorders. Divided into three sections and 24 chapters, Evidence-based Neurology: Management of Neurological Disorders: fills the gap between guidelines and primary studies as well as between primary and secondary scientific medical literature summarizes the most recent and important findings on treatments for neurological patients measures the benefit and, when applicable, the risk of harm inherent in specific neurological interventions. Each chapter starts with a brief definition of the clinical condition, together with its incidence and natural history. A clear formulation of a real-world scenario or question usually follows, structured using the standard three elements of patient, intervention, and outcome. The results are as quantitative as possible. This unique, evidence-based text, edited by members of the Cochrane Neurological Network will be

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Editorial Reviews

From the Publisher
“Chapters are well-written and balanced, carefully considering … the strengths and weaknesses of EBM … text will be useful for teaching medical students, residents … practicing neurologists and other clinicians.” (Journal of the American Medical Association)

“This book is a great help when patients confront me with information and I have to provide data on benefit or risk within 60 seconds.” (Lancet Neurology)

“The writing style is simple and clear. The editors have produced a book that should be accessible to students and practitioners at all levels.” (Doody’s Review Service)

Doody's Review Service
Reviewer: Michael Benatar, MD, PhD (Emory University School of Medicine)
Description: This edited compilation aims to present a summary of the best available evidence for the treatment of a range of neurological symptoms and disorders. The authors have employed an evidence-based approach, framing clinical questions and then systematically searching the literature to find answers. Where possible, meta-analysis is used to summarize data.
Purpose: The editors' stated purpose is threefold — to summarize the most recent and important findings on treatments for neurological patients, to provide answers to at least one therapeutic uncertainty within each chapter, and to measure the benefits (and harms) of specific neurological interventions. The editors make no claim to be comprehensive and despite the title, they clearly state that they do not pretend the book to be completely evidence-based. Within these self-imposed limitations, these objectives have been met.
Audience: This book is written for general neurologists. Many of the contributors have participated in the preparation of systematic reviews for the Cochrane Collaboration. Notwithstanding the sophistication of the information presented, the writing style is almost uniformly simple and clear. The editors have produced a book that really should be accessible to students and practitioners of neurology at all levels.
Features: The first of the book's three sections is introductory, providing an overview of methodological issues in evidence-based neurology. The second section is devoted to specific neurological symptoms and the final section covers individual neurological disorders. Although the spectrum of material covered is broad, it is not exhaustive. There is also a strong emphasis on treatment, with relatively little attention paid to issues surrounding diagnosis and prognosis (but the editors' intent was not to deal with these issues). Each chapter follows a uniform style, beginning with a brief introduction, followed by the statement of specific questions that are to be addressed and then a summary of the evidence. Liberal use is made of forest plots and other schematic and tabular representation of data. A few chapters are less evidence-based than others and these are the most disappointing. Fortunately, these are few in number.
Assessment: There are relatively few other evidence-based neurological books. Among them are Clinical Trials in Neurologic Practice by Biller and Bogousslavsky (Butterworth-Heinemann, 2001), Contemporary Treatments in Neurology by Scolding (Butterworth-Heinemann, 2001), and two I have authored, Analytic Neurology (Butterworth-Heinemann, 2003) and Neuromuscular Disease: Evidence and Analysis in Clinical Neurology (Humana, 2006). The first three of these texts are similarly focused exclusively on neurological therapeutics, whereas the latter considers issues in diagnosis and prognosis as well, although exclusively within the realm of neuromuscular disease. There is little overlap between Evidence-Based Neurology and these other books and, as such, it represents an important addition to this small but growing collection.
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Product Details

  • ISBN-13: 9780727918116
  • Publisher: Wiley
  • Publication date: 6/28/2007
  • Series: Evidence-Based Medicine Series, #17
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 288
  • Product dimensions: 9.00 (w) x 11.20 (h) x 0.76 (d)

Meet the Author

Livia Candelise, Cochrane Neurological Network, Dipartimento di Scienze Neurologiche, Ospedale Maggiore Policlinico, Universita’ degli Studi di Milano, Milan, Italy

Richard Hughes, Department of Clinical Neurosciences, King’s College London School of Medicine at Guy’s, King’s College and St Thomas’ Hospitals, London, UK

Alessandro Liberati. Department of Hematology and Oncology, University of Modena and Reggio Emilia, Azienda Ospedaliera Policlinico, Ferrara, Italy

Bernard Uitdehaag, Department of Neurology and Department of Clinical Epidemiology and Biostatistics, VU Medical Centre, Amsterdam, The Netherlands

Charles Warlow, Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK

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Table of Contents

Part 1 Introduction.

1 Evidence-based medicine: its contributions in the way we search, appraise and apply scientific information to patient care.

Alessandro Liberati, Lorenzo P. Moja, Ivan Moschetti.

2 What to do when there is no evidence.

Charles Warlow.

3 Outcome and adverse effect measures in neurology.

Jorge G. Burneo, Samuel Wiebe.

4 Systematic reviews of diagnostic research.

Bernard M.J. Uitdehaag, Peter M. Rothwell.

Part 2 Neurological symptoms/problems.

5 Acute migraine attacks.

Anne MacGregor.

6 Back and neck pain.

Harry McNaughton.

7 Neuropathic pain.

Giorgio Cruccu, Nadine Attal, Rod Taylor.

8 Vertigo and dizziness: treatment of benign paroxysmal positional vertigo, vestibular neuritis and Menière’s disease.

Michael Strupp, Thomas Brandt, Christian Daniel Cnyrim.

9 Sleep disorders.

Michel Billiard.

10 Cognitive rehabilitation of non-progressive neuropsychological disorders.

Stefano F. Cappa, Thomas Benke, Stephanie Clarke, Bruno Rossi, Brigitte Stemmer, Caroline M. van Heugten.

11 Management and pharmaceutical treatment of central and spinal spasticity.

David T. Shakespeare.

12 Background to neurorehabilitation.

Kathryn McPherson, Paula Kersten, Lynne Turner-Stokes.

Part 3 Neurological diseases.

13 Acute stroke management and prevention of recurrences.

Gord Gubitz.

14 Aneurysmal subarachnoid haemorrhage.

Jan van Gijn, Gabriel J.E. Rinkel.

15 Acute traumatic brain injury.

Miguel F. Arango, Walter Videtta, Corina Puppo.

16 Corticosteroids in central nervous system infections.

Anu Jacob, Tom Solomon, Paul Garner.

17 Brain tumours.

Michael G. Hart, Robin Grant.

18 Epilepsy.

Sridharan Ramaratnam, Anthony Marson.

19 Dementia treatment: let the evidence lead us.

Bart M. Demaerschalk, Bryan K. Woodruff, Richard J. Caselli.

20 Parkinson’s disease.

Miguel Coelho, Joaquim Ferreira, Cristina Sampaio.

21 Multiple sclerosis: critical review of the evidence for each question.

Graziella Filippini, George Ebers.

22 Motor neurone disorders.

Douglas Mitchell.

23 Peripheral nerve disorders.

Richard Hughes, Eva L. Feldman, Jeremy D.P. Bland.

24 Muscle disorders.

Fiona Norwood, Michael R. Rose.


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