Evidence-based Pediatric Oncology / Edition 2

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Using the available systematic reviews and Standard Options Recommendations (SORs) which are evidence-based treatment recommendations, Evidence-based Pediatric Oncology is a ground breaking text on the management of childhood cancers. Covering all tumour types occuring in children and young adults, it provides systematic reviews with recommendations for optimum treatments for childhood cancer.

Offering reviews and commentaries from leading internationally recognised paediatric oncologists, this fully revised second edition now covers significant randomised controlled trails.

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Editorial Reviews

From the Publisher
"This reference provides a useful "one-stop shop" for some of the key data from RCTs in paediatric oncology. The study summaries are short enough to be easily digested while having sufficient detail to allow readers to glean key facts." (EBM, February 2009)

"The book provides good material for readers to get up-to-date with the latest clinical trials in the field of pediatric oncology … .The information given is up-to-date and is presented in a simple and easy to understand manner" (Sultan Qaboos University Medical Journal, December 2007)

"[T]he book has an international feel and the writers comment on American and European views. Perspective, hard facts and evidence based is the strength of this book, a heavyweight in his clas." (Bulletin of the Royal College of Pathologists)

“This book must be in the library of any practicing pediatric oncologist … authors do not follow the classic format … but instead focus on the presentation of important … trials.” (Doodys Book Reviews)

Doody's Review Service
Reviewer: Rafael Ducos, MD (Ochsner for Children)
Description: This is a comprehensive review and analysis of clinical trials in pediatric oncology. The authors describe the significant therapeutic trials that over the years have dramatically improved the prognosis for childhood cancer. In addition to describing the trials, the authors summarize the conclusions for each trial and provide background information for the treatment of each pediatric tumor.
Purpose: The purpose is to summarize the available information on randomized trials in childhood cancer. The intent is to not only show clinical trial data, but to provide a rational evidence base for current practice in pediatric oncology. The book also indicates where there are gaps in our knowledge and new studies are a priority.
Audience: Aimed at practitioners in the field of pediatric oncology, this book must be in the library of any practicing pediatric oncologist or pediatric oncology trainee. It may be too research oriented for general pediatric practitioners.
Features: The book is divided into three parts, one devoted to the most common solid tumors in children, the second to leukemia, and the third to supportive care in pediatric cancer. The format is the same for the chapters in each part. There is an initial commentary by one or more experts on the topic, with basic background information on the specific cancer. This is followed by basic background information on the specific tumor and a critical review of the different trials, showing the potential difficulties encountered in doing the research, lessons to be learned for future clinical research, and general conclusions that the commentators can draw in reviewing the studies. Each chapter concludes with the presentation of the different therapeutic trials with the objectives, details, outcome, toxicity, and conclusions.
Assessment: This is, indeed, an excellent book for practicing pediatric oncologists and pediatric hematology/oncology fellows. The authors do not follow the classic format of other textbooks, but instead focus on the presentation of important randomized therapeutic trials that they have selected. Behind their approach is the concept of evidence-based guidelines for clinical practice. In this manner, this book fills a gap in the pediatric oncology literature, where the available information is scattered in multiple publications. I have not seen any other pediatric oncology books with this format. This is the second edition, and indeed, this type of book will require periodic updates to keep readers abreast of current evidence-based therapies for childhood cancer.
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Product Details

  • ISBN-13: 9781405142687
  • Publisher: Wiley
  • Publication date: 5/28/2007
  • Series: Evidence-Based Medicine Series
  • Edition description: Revised
  • Edition number: 2
  • Pages: 576
  • Product dimensions: 7.70 (w) x 10.00 (h) x 1.36 (d)

Meet the Author

Ross Pinkerton Mater Hospitals, Raymond Terrace, Brisbane, Australia

AG Shankar Department of Paediatric and Adolescent Oncology, University College of London NHS Trust, London, UK

Katherine Matthay Department of Pediatric Oncology, University of California at San Francisco, CA, USA

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Table of Contents


Ross Pinkerton.

Part 1: Solid Tumors.

Ross Pinkerton.

1 Rhabdomyosarcoma.

Commentary by Michael Stevens and Meriel Jenney.

2 Osteosarcoma.

Commentary by Alan Craft.

3 Ewing’s sarcoma.

Commentary by Alan Craft.

4 Wilms’ tumor.

Commentary by Daniel Green.

5 Neuroblastoma.

Commentary by Katherine Matthay.

6 Hepatoblastoma and malignant germ-cell tumors.

Commentary by Ross Pinkerton.

7 Medulloblastoma.

Commentary by Joann Ater.

8 Glioma.

Commentary by Joann Ater.

9 Non-Hodgkin’s lymphoma.

Commentary by Tim Eden and Ross Pinkerton.

10 Hodgkin’s disease.

Commentary by Tim Eden and Ross Pinkerton.

Part 2: Leukemia.

AG Shankar.

Acute myeloid leukemia.

Commentaries by Judith Chessells and Vaskar Saha.

11 Induction regimens in acute myeloid leukemia.

12 Role of autologous BMT in children with acute myeloid leukemia in first remission.

13 Role of maintenance treatment in childhood acute myeloid leukemia.

Childhood lymphoblastic leukemia.

Commentaries by Vaskar Saha and Judith Chessells.

14 Steroids and asparaginases during remission induction therapy in childhood lymphoblastic leukemia.

15 CNS prophylaxis in childhood lymphoblastic leukemia.

16 Continuing therapy in childhood lymphoblastic leukemia – duration of continuing therapy.

Part 3: Supportive Care in Pediatric Oncology.

Katherine Matthay and AG Shankar.

17 Use of hemopoietic colony stimulating factors (G-CSF, G-MCSF and erythropoietin).

18 Cardioprotection in pediatric oncology.


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