Evidence-Based Pediatric Oncology

Overview

This book is updated with evidence from the latest published reviews and is more clinically focused, with an emphasis on application of the trial findings. With increased coverage of trials in the area of supportive care for pediatric cancer patients, each chapter opens with a clinical question and concludes with a summary on the trial findings from an expert commentator.

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Overview

This book is updated with evidence from the latest published reviews and is more clinically focused, with an emphasis on application of the trial findings. With increased coverage of trials in the area of supportive care for pediatric cancer patients, each chapter opens with a clinical question and concludes with a summary on the trial findings from an expert commentator.

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Editorial Reviews

From the Publisher
"This reference provides a useful "one-stop shop" for some of the key data from RCTs in paediatric oncology. The study summaries are short enough to be easily digested while having sufficient detail to allow readers to glean key facts." (EBM, February 2009)

"The book provides good material for readers to get up-to-date with the latest clinical trials in the field of pediatric oncology … .The information given is up-to-date and is presented in a simple and easy to understand manner" (Sultan Qaboos University Medical Journal, December 2007)

"[T]he book has an international feel and the writers comment on American and European views. Perspective, hard facts and evidence based is the strength of this book, a heavyweight in his clas." (Bulletin of the Royal College of Pathologists)

“This book must be in the library of any practicing pediatric oncologist … authors do not follow the classic format … but instead focus on the presentation of important … trials.” (Doodys Book Reviews)

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Product Details

  • ISBN-13: 9780470659649
  • Publisher: Wiley
  • Publication date: 5/20/2013
  • Series: Evidence-Based Medicine Series
  • Edition number: 3
  • Pages: 294
  • Product dimensions: 18.00 (w) x 9.60 (h) x 0.70 (d)

Meet the Author

Edited by
Ross Pinkerton, MB, BCh, BaO, MD, Executive Director, Division of Oncology, Royal Children’s Hospital, Children’s Health Queensland, Brisbane, QLD, Australia

Ananth Shankar, MD, FRCPCH, Consultant in Paediatric and Adolescent Oncology, University College
London Hospitals NHS Foundation Trust, London, UK

Katherine K. Matthay, BA, MD, Mildred V. Strouss Professor of Translational Oncology, Director, Pediatric Hematology-Oncology, Department of Pediatrics, UCSF School of Medicine and UCSF Benioff Children’s Hospital, San Francisco, CA, USA

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Table of Contents

List of contributors, vii

Preface, ix

List of abbreviations, x

About the companion website, xv

Part 1: Solid tumors

1 Rhabdomyosarcoma, 3
Katherine K. Matthay

(Commentary by Meriel Jenney)

2 Osteosarcoma, 14
Katherine K. Matthay

(Commentary by Maria Michelagnoli)

3 Ewing sarcoma, 25
Katherine K. Matthay

(Commentary by Steven G. DuBois)

4 Wilms tumor, 34
Ananth Shankar

(Commentary by Kathy Pritchard-Jones)

5 Neuroblastoma, 47
Katherine K. Matthay

(Commentary by Katherine K. Matthay)

6 Hepatoblastoma, 58
Ross Pinkerton

(Commentary by Penelope Brock)

7 Malignant germ cell tumors, 65
Ross Pinkerton

(Commentary by Ross Pinkerton)

8 Medulloblastoma, 69
Ross Pinkerton

(Commentary by Eric Bouffet)

9 Glioma, 81
Ross Pinkerton

(Commentary by Joann L. Ater)

10 Non-Hodgkin lymphoma, 88
Ross Pinkerton

(Commentary by Ross Pinkerton)

11 Hodgkin lymphoma, 105
Ross Pinkerton

(Commentary by Cindy L. Schwartz)

Part 2: Leukemia

Section 1: Acute myeloid leukemia 12 Acute myeloid leukemia commentary, 119
Robert J. Arceci

13 Remission induction in acute myeloid leukemia, 126
Ananth Shankar

14 Acute myeloid leukemia consolidation, 135
Ananth Shankar

15 Maintenance treatment in acute myeloid leukemia, 137
Ananth Shankar

16 Autologous bone marrow transplantation in acute myeloid leukemia, 141
Ananth Shankar

17 Acute myeloid leukemia: miscellaneous, 144
Ananth Shankar

Section 2: Childhood lymphoblastic leukemia

18 Childhood lymphoblastic leukemia commentary, 146
Vaskar Saha

19 Remission induction in childhood lymphoblastic leukemia, 154
Ananth Shankar

20 Central nervous system-directed therapy in childhood lymphoblastic leukemia, 168
Ananth Shankar

21 Maintenance treatment in childhood lymphoblastic leukemia, 180
Ananth Shankar

22 Relapsed childhood lymphoblastic leukemia, 198
Ananth Shankar

23 Postinduction therapy in adolescents and young adults with acute lymphoblastic leukemia, 204
Ananth Shankar

Part 3: Supportive care in pediatric oncology

24 Colony-stimulating factors, 209
Ananth Shankar

(Commentary by Victoria Grandage)

25 Cardioprotection in pediatric oncology, 230
Ananth Shankar

(Commentary by Gill A. Levitt)

26 Infections in pediatric and adolescent oncology, 243
Ananth Shankar and Sara Stoneham

(Commentary by Julia E. Clark)

Index, 269

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