Evolution, Development, and the Predictable Genome

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Overview

For too long, efforts to synthesize evolution and development have failed to build a united view of the origins and evolution of biological diversity. In this groundbreaking book, David Stern sets out to draw evolutionary biology and developmental biology together by cutting through the differences that divide the disciplines and by revealing their deeper similarities. He draws upon the insights of generations of evolutionary biologists and scores of developmental biologists to build a solid foundation for future investigation of the genetic and developmental causes of diversity. Along the way, and in plain English, he explicates many of the guiding principles of evolution, population genetics, and developmental biology. Each chapter offers a clear review of fundamental principles, together with thoughtprovoking ideas that will be tested only with data emerging from current and future studies. With the basic principles established, he then offers a new way of thinking about development—backwards—to clarify precisely how the mechanisms of development influence evolution. In the same spirit, he takes a fresh look at evolution in populations, arguing that population history influences precisely how developmental mechanisms evolve. Both Stern's new perspective on development and his reassessment of the role of populations leads to the surprising conclusion that the evolution of genomes appears to be predictable. Stern argues that developmental biology and evolutionary biology are intertwined: it is impossible to understand one of them fully without understanding the other. This book provides a clear and wide-ranging introduction to evolution and development for the basic reader; graduate students will be introduced to the cutting-edge of research in evolutionary developmental biology; and experts in evolution or development will receive both an uncomplicated introduction to the other discipline and an abundance of new, provocative ideas.

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Product Details

  • ISBN-13: 9781936221011
  • Publisher: Roberts and Company Publishers
  • Publication date: 3/1/2010
  • Edition description: 1st Edition
  • Pages: 208
  • Product dimensions: 6.10 (w) x 9.10 (h) x 1.10 (d)

Meet the Author

David Stern is Professor of Ecology and Evolutionary Biology and an Investigator with the Howard Hughes Medical Institute at Princeton University. His research addresses the genetic causes of evolution, and his laboratory is currently focused on the evolution of morphology and behavior.

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Table of Contents

Preface xi

1 In Order to form a More Perfect Union 1

2 Scale Matter 5

3 Dominance 21

4 Pleiotropy 49

5 Epistasis 79

6 Populations And Natural Selection 101

7 Pathworks 117

8 The Predictable Genome 149

Historical Note 175

Acknowledgments 181

Notes 185

Further Reading 221

Bibliography 227

Index 251

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