Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction by Philippa Marrack, James P. Scott-Browne, Shaodong Dai, Laurent Gapin | | NOOK Book (eBook) | Barnes & Noble
Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction

Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction

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by Philippa Marrack, James P. Scott-Browne, Shaodong Dai, Laurent Gapin
     
 
The rules for the conserved reaction of αβ T cell receptors (TCRs) with major histocompatibility complex (MHC) proteins plus peptides are poorly understood, probably because thymocytes bearing TCRs with the strongest MHC reactivity are lost by negative selection. Thus, only TCRs with an attenuated ability to react with MHC appear on mature T cells. Also,

Overview

The rules for the conserved reaction of αβ T cell receptors (TCRs) with major histocompatibility complex (MHC) proteins plus peptides are poorly understood, probably because thymocytes bearing TCRs with the strongest MHC reactivity are lost by negative selection. Thus, only TCRs with an attenuated ability to react with MHC appear on mature T cells. Also, the interaction sites between TCRs and MHC may be inherently flexible and hence difficult to spot. We reevaluated contacts between TCRs and MHC in the solved structures of their complexes with these points in mind. Relatively conserved amino acids in the TCR complementarity-determining regions (CDR) 1 and CDR2 are often used to bind exposed areas of the MHC α-helices. These areas are exposed because of small amino acids that allow somewhat flexible binding of the TCRs. The TCR amino acids involved are specific to families of variable (V) regions and to some extent different rules may govern the recognition of MHCI versus MHCII.

Product Details

ISBN-13:
2940013246317
Publisher:
Annual Reviews
Publication date:
10/24/2011
Series:
Annual Review of Immunology , #26
Sold by:
Barnes & Noble
Format:
NOOK Book
Pages:
32
File size:
8 MB

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Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction 5 out of 5 based on 0 ratings. 2 reviews.
Anonymous More than 1 year ago
Sorry, but since I am Leafpool, the apprentice has to be Jaypaw. The rules said if possible use a real charecter.
Anonymous More than 1 year ago