Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction [NOOK Book]

Overview

The rules for the conserved reaction of αβ T cell receptors (TCRs) with major histocompatibility complex (MHC) proteins plus peptides are poorly understood, probably because thymocytes bearing TCRs with the strongest MHC reactivity are lost by negative selection. Thus, only TCRs with an attenuated ability to react with MHC appear on mature T cells. Also, the interaction sites between TCRs and MHC may be inherently flexible and hence difficult to spot. We reevaluated contacts between TCRs and MHC in the solved ...
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Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction

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Overview

The rules for the conserved reaction of αβ T cell receptors (TCRs) with major histocompatibility complex (MHC) proteins plus peptides are poorly understood, probably because thymocytes bearing TCRs with the strongest MHC reactivity are lost by negative selection. Thus, only TCRs with an attenuated ability to react with MHC appear on mature T cells. Also, the interaction sites between TCRs and MHC may be inherently flexible and hence difficult to spot. We reevaluated contacts between TCRs and MHC in the solved structures of their complexes with these points in mind. Relatively conserved amino acids in the TCR complementarity-determining regions (CDR) 1 and CDR2 are often used to bind exposed areas of the MHC α-helices. These areas are exposed because of small amino acids that allow somewhat flexible binding of the TCRs. The TCR amino acids involved are specific to families of variable (V) regions and to some extent different rules may govern the recognition of MHCI versus MHCII.
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Product Details

  • BN ID: 2940013246317
  • Publisher: Annual Reviews
  • Publication date: 10/24/2011
  • Series: Annual Review of Immunology, #26
  • Sold by: Barnes & Noble
  • Format: eBook
  • Pages: 32
  • File size: 8 MB

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Sort by: Showing all of 4 Customer Reviews
  • Anonymous

    Posted May 25, 2014

    Leafpool to Artickit

    Sorry, but since I am Leafpool, the apprentice has to be Jaypaw. The rules said if possible use a real charecter.

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  • Anonymous

    Posted May 24, 2014

    Darkkit

    "I wish to become medicine cat apprentice."

    Was this review helpful? Yes  No   Report this review
  • Anonymous

    Posted May 24, 2014

    Arctickit to darkkit

    Sup?

    Was this review helpful? Yes  No   Report this review
  • Anonymous

    Posted May 12, 2014

    Mentor and Apprentice Matchroom

    Was this review helpful? Yes  No   Report this review
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