Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics: 8th European Conference, EvoBIO 2010, Istanbul, Turkey, April 7-9, 2010, Proceedings / Edition 1

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This book constitutes the refereed proceedings of the 7th European Conference on Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics, EvoBIO 2010, held in Istanbul, Turkey, in April 2010 co-located with the Evo* 2010 events.
This 15 revised full papers were carefully reviewed and selected from 40 submissions. EvoBIO is the premiere European event for those interested in the interface between evolutionary computation, machine learning, data mining, bioinformatics, and computational biology. Topics addressed by the papers include biomarker discovery, cell simulation and modeling, ecological modeling, fluxomics, gene networks, biotechnology, metabolomics, microarray analysis, phylogenetics, protein interactions, proteomics, sequence analysis and alignment, and systems biology.

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Table of Contents

Variable Genetic Operator Search for the Molecular Docking Problem Salma Mesmoudi Jorge Tavares Laetitia Jourdan El-Ghazali Talbi 1

Role of Centrality in Network-Based Prioritization of Disease Genes Sinan Erten Mehmet Koyutürk 13

Parallel Multi-Objective Approaches for Inferring Phylogenies Waldo Cancino Laetitia Jourdan El-Ghazali Talbi Alexandre C.B. Delbem 26

An Evolutionary Model Based on Hill-Climbing Search Operators for Protein Structure Prediction Camelia Chira Dragos Horvath Dumitru Dumitrescu 38

Finding Gapped Motifs by a Novel Evolutionary Algorithm Chengwei Lei Jianhua Ruan 50

Top-Down Induction of Phylogenetic Trees Celine Vens Eduardo Costa Hendrik Blockeel 62

A Model Free Method to Generate Human Genetics Datasets with Complex Gene-Disease Relationships Casey S. Green Daniel S. Himmelstein Jason H. Moore 74

Grammatical Evolution of Neural Networks for Discovering Epistasis among Quantitative Trait Loci Stephen D. Turner Scott M. Dudek Marylyn D. Ritchie 86

Grammatical Evolution Decision Trees for Detecting Gene-Gene Interactions Sushamna Deodhar Alison Motsinger-Reif 98

Identification of Individualized Feature Combinations for Survival Prediction in Breast Cancer: A Comparison of Machine Learning Techniques Leonardo Vanneschi Antonella Farinaccio Mario Giacobini Giancarlo Mauri Marco Antoniotti Paolo Provero 110

Correlation-Based Scatter Search for Discovering Biclusters from Gene Expression Data Juan A. Nepomuceno Alicia Troncoso Jesús S. Aguilar-Ruiz 122

A Local Search Approach for Transmembrane Segment and Signal Peptide Discrimination Sami Laroum Dominique Tessier Béatrice Duval Jin-Kao Hao 134

A Replica Exchange Monte Carlo Algorithm for the Optimization of Secondary Structure Packing in Proteins Leonidas Kapsokalivas Kathleen Steinhöfel 146

Improving Multi-Relief for Detecting Specificity Residues from Multiple Sequence Alignments Elena Marchiori 158

Using Probabilistic Dependencies Improves the Search of Conductance-Based Compartmental Neuron Models Roberto Santana Concha Bielza Pedro Larrañaga 170


The Informative Extremes: Using Both Nearest and Farthest Individuals Can Improve Relief Algorithms in the Domain of Human Genetics Casey S. Greene Daniel S. Himmelstein Jeff Kiralis Jason H. Moore 182

Artificial Immune Systems for Epistasis Analysis in Human Genetics Nadia M. Penrod Casey S. Greene Delaney Granizo-MacKenzie Jason H. Moore 194

Metaheuristics for Strain Optimization Using Transcriptional Information Enriched Metabolic Models Paulo Vilaça Paulo Maia Isabel Rocha Miguel Roch 205

Using Rotation Forest for Protein Fold Prediction Problem: An Empirical Study Abdollah Dehzangi Somnuk Phon-Amnuaisuk Mahmoud Manafi Soodabeh Safa 217

Towards Automatic Detecting of Overlapping Genes - Clustered BLAST Analysis of Viral Genomes Klaus Neuhaus Daniela Oelke David Fürst Siegfried Scherer Daniel A. Keim 228

Investigating Populational Evolutionary Algorithms to Add Vertical Meaning in Phylogenetic Trees Francesco Cerutti Luigi Bertolotti Tony L. Goldberg Mario Giacobini 240

Author Index 249

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