Excitatory Amino Acid Receptors: Design of Agonists and Antagonists

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New York 1992 Hardcover Very Good Ex-Library Cond Book 8vo-over 7?"-9?" tall 382 pgs. Usual library markings. Clean pages, tight binding. Two corners lightly bumped. Richly ... illustrated with formulas, diagrams and scematic outlines of complex biological and biochemical phenomena, modern techniques such as x-ray, molecular modelling and other computer-based methods are used to depict and analyse molecular and structure-activity relationships. Incorporates stereochemical principles into all the analyses, and various techniques, including enzymatic and advances chromatographic emthods, which are used for the preparation and separation of steroisomers of EAA ligands, are described in detail. Blue/black illustrated glossy boards with white lettering. Read more Show Less

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New York 1992 Hardcover Very Good Ex-Library Cond Book 8vo-over 7?"-9?" tall 382 pgs. Richly illustrated with formulas, diagrams and scematic outlines of complex biological and ... biochemical phenomena, modern techniques such as x-ray, molecular modelling and other computer-based methods are used to depict and analyse molecular and structure-activity relationships. Incorporates stereochemical principles into all the analyses, and various techniques, including enzymatic and advances chromatographic emthods, which are used for the preparation and separation of steroisomers of EAA ligands, are described in detail. Blue/black illustrated glossy boards with white lettering. Usual library markings. Clean and tightly bound. Read more Show Less

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1992 Hardcover, ex-library, with usual stamps and markings, in good all round condition. Ships within 24 hours. pp., 850grams, ISBN: 0132967162. *****PLEASE NOTE: This item is ... shipping from an authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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Product Details

Table of Contents

Preface 7
Abbreviations of names of compounds 9
1 Excitatory amino acids, excitotoxicity and neurodegenerative disorders 13
2 Excitatory amino acid receptors: multiplicity and ligand selectivity of receptor subtypes 34
3 Isolation and structural characterization of excitatory amino acid receptors 56
4 Electrophysiological techniques for the study of excitatory amino acids in mammalian neurons in slice preparations 86
5 Receptor autoradiography of excitatory amino acid receptors: basic and clinical aspects 101
6 NMDA receptors: heterogeneity and agonism 121
7 Sulphur-containing excitatory amino acids 162
8 Competitive NMDA receptor antagonists 183
9 Ligands for NMDA receptor modulatory sites 201
10 AMPA receptor agonists: structural, conformational and stereochemical aspects 216
11 Quinoxalinediones as AMPA receptor antagonists: mechanism and structure-activity studies 246
12 Kainic acid receptor agonists 261
13 Polyamine toxins as excitatory amino acid receptor ligands 292
14 L-AP4 receptor ligands 308
15 The quisqualate metabotropic receptor coupled to phospholipase C(Qp) 331
16 Therapeutic opportunities in modulators of excitatory amino acid-mediated neurotransmission 352
Index 376
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