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Experimental Approaches to Anxiety and Depression

Overview

Reinvestigates aspects of experimental and clinical evidence in these two mental disorders on the basis of new concepts. A number of renowned authorities contribute articles concerned with recent discoveries involving specific neurotransmitters. Coverage includes tests to predict antidepressant actions, neurochemical and neuropharmaceutical prospects, biochemical effects of antidepressant and anxiolytic drugs on receptor mechanisms, common noradrenergic dysfunction in these ailments, the potential importance of ...
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Overview

Reinvestigates aspects of experimental and clinical evidence in these two mental disorders on the basis of new concepts. A number of renowned authorities contribute articles concerned with recent discoveries involving specific neurotransmitters. Coverage includes tests to predict antidepressant actions, neurochemical and neuropharmaceutical prospects, biochemical effects of antidepressant and anxiolytic drugs on receptor mechanisms, common noradrenergic dysfunction in these ailments, the potential importance of dopamine and much more.

This book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Joseph G. Fanelli, MD (Rush University Medical Center)
Description: This book contains the presentations comprising the Biological Council's 1991 Symposium on Drug Action, which sought to explore clinical and experimental evidence regarding the interplay of brain systems in anxiety and depression.
Purpose: The purposes are to relate the symposium's proceedings and to honor a noted pharmacologist for his career of service to the Biological Council.
Audience: The audience is the psychopharmacologist, and with few exceptions, the work addresses its audience quite appropriately. Both clinical research and practicing psychopharmacologists will find this book interesting and useful.
Features: The text is amply and appropriately illustrated with black-and-white tables, figures, and a few photographs. References are of generally high quality, though the lag to publication (the Symposium having been held in 1991) renders some sections unavoidably lacking. A special treat is the first section, authored by symposium honoree Merton Sandler. It is a must-read for any psychopharmacologist. The cover art is poor and betrays the depth of useful material in the book (as well as the price).
Assessment: The title of this book fails to do justice to what is, on the whole, a desirable and useful work for the psychopharmacologist. Many of the chapters contribute useful knowledge needed in developing and testing models of anxiety and depression and in applying these models to treatment settings. Two chapters detract from the quality of the work in a rather obvious and unfortunate way. One chapter describes lab work with dopamine receptors, and the other is a poor discussion of clinical material.

3 Stars from Doody
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Product Details

Table of Contents

Contributors
Series Preface
Preface
1 Development of Anxiolytic and Antidepressant Drugs: A Historical Perspective 1
2 Anxiety and Depression: A Clinical Profile 9
3 Behavioural Detection of Anxiolytic Action 25
4 A Neural Systems Approach to the Study of the Amygdala, Fear and Anxiety 45
5 Behavioural Models of Depression 73
6 Neurochemical Correlates of Antidepressant and Anxiolytic Treatments 87
7 Noradrenergic Mechanisms in Anxiolytic and Antidepressant Drug Action 101
8 Biochemical Measurement of Serotonergic Neurotransmission In Vivo: Effect of Antidepressant and Anxiolytic Treatments 117
9 The Role of GABA in Anxiolytic/Antidepressant Drug Action 151
10 GABA Receptor Composition and Function in Relation to Drug Action 169
11 Molecular Characterization of D[subscript 1] Dopamine Receptors 183
12 Current Concepts of Serotonin Neuronal Function and the Pathophysiology of Depression 197
13 Are Animal Models of Mental Illness Viable? 219
14 Amine Mechanisms in Anxiety and Depression 233
15 New Directions in the Development of Anxiolytic and Antidepressant Drugs 245
Index 265
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