Familial Breast and Ovarian Cancer: Genetics, Screening and Management

Familial Breast and Ovarian Cancer: Genetics, Screening and Management

by Patrick J. Morrison, Shirley V. Hodgson, Neva E. Haites
     
 

This book surveys the ramifications that have arisen from the significant advances in our understanding of the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, it provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in the diagnosis, genetics, screening,… See more details below

Overview

This book surveys the ramifications that have arisen from the significant advances in our understanding of the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, it provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in the diagnosis, genetics, screening, prevention and management of familial breast cancer. In this rapidly advancing field, this book provides an unrivalled source of information, including sections on ethical and insurance issues and the different cultural aspects of breast cancer. The use of recently devised cancer genetics clinics and different referral criteria and patterns to these clinics are also detailed. This book will be of value to all clinical geneticists, oncologists and healthcare professionals involved in screening and counselling programmes.

Product Details

ISBN-13:
9780521017770
Publisher:
Cambridge University Press
Publication date:
07/31/2005
Pages:
420
Product dimensions:
6.85(w) x 9.72(h) x 0.87(d)

Table of Contents

List of contributors
Foreword
Preface
1Introduction3
2Overview of the clinical genetics of breast cancer6
3Cowden syndrome and related disorders22
4Overview of the clinical genetics of ovarian cancer43
5Ovarian and breast cancer as part of hereditary non-polyposis colorectal cancer (HNPCC) and other hereditary colorectal cancer syndromes73
6The natural history of hereditary breast cancer81
7Pathology of the breast and ovary in mutation carriers108
8Risk estimation for familial breast and ovarian cancer125
9Developing a cancer genetics service: a Welsh model143
10Referral criteria for cancer genetics clinics157
11Guidelines for the development of cancer genetics services166
12Cultural and educational aspects influencing the development of cancer genetics services in different European countries194
13Screening, detection and survival patterns of breast and other cancers in high-risk families204
14Screening for familial ovarian cancer220
15Management of BRCA1/2 mutation carriers237
16Management of familial ovarian cancer275
17Prophylactic mastectomy in mutation carriers286
18Psychosocial aspects of genetic counselling for breast and ovarian cancer295
19BRCA1/2 testing: uptake and its measurement306
20Breast cancer genetics: ethical, social and insurance issues339
21Gene therapy for breast and ovarian cancer372
22Future directions384
Index393

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