Familial Breast and Ovarian Cancer: Genetics, Screening and Management

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Overview

This book surveys the ramifications that have arisen from the significant advances in our understanding of the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, it provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in the diagnosis, genetics, screening, prevention and management of familial breast cancer. In this rapidly advancing field, this book provides an unrivalled source of information, including sections on ethical and insurance issues and the different cultural aspects of breast cancer. The use of recently devised cancer genetics clinics and different referral criteria and patterns to these clinics are also detailed. This book will be of value to all clinical geneticists, oncologists and healthcare professionals involved in screening and counselling programmes.
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Editorial Reviews

From the Publisher
"This text book is a timely publication and it gives a splendid overview of the genetics and management of familial breast and ovarian cancer...practical, up to date and well referenced...Colleagues throughout the profession from a wide range of disciplines will find much in this book to interest them and will help them guide and manage their patients through the difficult decision journey of familial cancer." Ulster Medical Journal

"...a very good state-of-the-art document of the current knowledge, covering most aspects of the genetic background and the clinical management of suspected familial breast and ovarian cancer...recommended for newcomers to the field of cancer genetics, and for those interested clinicians and policymakers who need a comprehensive base for maintaining and developing a clinical service." Hum Genet

"Over all, the text is very readable for a general scientific audience....This edited text covers all of the major areas of interest in considering familial and hereditary breast and ovarian cancers. Although the editors, most authors, and the focus on services are European, there are enough commonalities to make the book a worthwhile purchase for North American readers as well." American Journal of Human Genetics

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Product Details

  • ISBN-13: 9780521017770
  • Publisher: Cambridge University Press
  • Publication date: 7/31/2005
  • Pages: 420
  • Product dimensions: 6.85 (w) x 9.72 (h) x 0.87 (d)

Meet the Author

Consultant clinical geneticist with a special interest in cancer genetics, in the Northern Ireland Regional Genetics Service. Qualified MB BCh BAO in 1986 and MD in 1993 from Queens' University Belfast. Held molecular biology and neurogenetics research fellowships from the Royal College of Physicians in Ireland from 1991-1994. Member of the UK Government's Human Genetics Commission, World Federation of Neurology Research Group in Huntingdon Disease, a steering group member on the International Collaborative group on hereditary breast and ovarian cancer (ICG-HBOC) and a council member of the Irish Society of Human Genetics. Involved in many other genetics and cancer societies. Published over 100 peer-reviewed articles on all aspects of genetics, particularly late onset neurogenetics diseases, familial cancers and insurance isuues.

Prof in Medical Genetics, University of Aberdeen, Head of Service in Medical Genetics and Honorary Consultant Clinical Genetics, Grampian University Hospitals NHS Trust Degrees held:- BSc (Hons - 1st class)1968 PhD - Qld MBChB (Hons) - Aberdeen 1980 FRCPath FRCP (Edin) FRCP (Lon) Clinical interests include families with an inherited predisposition to cancer Currently Chair the Cancer Genetics Sub-Group of the Scottish Cancer Group at the Scottish Office Currently Chair of the British Society of Human Genetics Research Interests Service models for familial cancer Molecular aspects of Charcot Marie Tooth disease, polycystic ovarian syndrome, talipes equino varus Diagnosis and identification of genes implicated in sporadic and familial cancer

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Table of Contents

List of contributors
Foreword
Preface
1 Introduction 3
2 Overview of the clinical genetics of breast cancer 6
3 Cowden syndrome and related disorders 22
4 Overview of the clinical genetics of ovarian cancer 43
5 Ovarian and breast cancer as part of hereditary non-polyposis colorectal cancer (HNPCC) and other hereditary colorectal cancer syndromes 73
6 The natural history of hereditary breast cancer 81
7 Pathology of the breast and ovary in mutation carriers 108
8 Risk estimation for familial breast and ovarian cancer 125
9 Developing a cancer genetics service: a Welsh model 143
10 Referral criteria for cancer genetics clinics 157
11 Guidelines for the development of cancer genetics services 166
12 Cultural and educational aspects influencing the development of cancer genetics services in different European countries 194
13 Screening, detection and survival patterns of breast and other cancers in high-risk families 204
14 Screening for familial ovarian cancer 220
15 Management of BRCA1/2 mutation carriers 237
16 Management of familial ovarian cancer 275
17 Prophylactic mastectomy in mutation carriers 286
18 Psychosocial aspects of genetic counselling for breast and ovarian cancer 295
19 BRCA1/2 testing: uptake and its measurement 306
20 Breast cancer genetics: ethical, social and insurance issues 339
21 Gene therapy for breast and ovarian cancer 372
22 Future directions 384
Index 393
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