Fatigue as a Window to the Brain

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Although fatigue has been actively investigated for more than 100 years, we have progressed little in either its theoretical or practical understanding. Fatigue has been considered to be both a symptom and an illness. Fatigue is a primary reason for patient visits to the physician's office, but it is difficult to measure and offers doctors little important information for diagnosis. Fatigue as a Window to the Brain gathers experts on a wide variety of disorders to consider what the presence of fatigue tells us about how the brain works — more specifically, to identify the neural mechanisms potentially responsible for fatigue. The book looks at many of the major conditions in which fatigue is observed, with the hope that patterns may emerge that will suggest paths for future research. It will be of interest to neuroscientists, clinical researchers, and physicians and other clinicians.

After discussing the nature of fatigue — its history and epidemiology and its assessment, measurement, and interpretation — the book turns to specific conditions associated with fatigue. It considers neurological conditions,including multiple sclerosis and stroke; psychiatric conditions as well as the overall treatment of fatigue in psychiatry; and general medical conditions, including HIV, heart disease, lupus, cancer,and others. The book then offers an overview of treatment approaches. It concludes with a definition of fatigue — both "primary" and "secondary" — and suggestions for future study.

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Editorial Reviews

The New England Journal of Medicine - Ingvard Wilhelmsen
... enlightening and loaded with updates from recent research. All physicians treating patients with fatigue should read it.
From the Publisher
"...enlightening and loaded with updates from recent research. All physicians treating patients with fatigue should read it." Ingvard Wilhelmsen, MD, PhD The New England Journal of Medicine
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Product Details

Meet the Author

John DeLuca is Director of Neuroscience Research at the Kessler Medical RehabilitationResearch and Education Corporation, Professor of Physical Medicine and Rehabilitation, and Professor of Neurosciences at the University of Medicine and Dentistry of New Jersey-New Jersey MedicalSchool.

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Table of Contents

1 What is fatigue? : history and epidemiology 3
2 The assessment and measurement of fatigue 19
3 Fatigue, cognition, and mental effort 37
4 Multiple sclerosis and fatigue 61
5 Fatigue after stroke 73
6 Fatigue after traumatic brain injury 89
7 Fatigue in other neurological conditions 107
8 The diagnosis and treatment of fatigue in psychiatry : a historical overview 127
9 Chronic fatigue syndrome and the brain 137
10 Depression and fatigue 157
11 Fatigue and somatization 173
12 HIV-related fatigue 187
13 Fatigue and sleep 209
14 Heart disease, cardiovascular functioning, and fatigue 229
15 Fatigue in systemic lupus erythematosus and related autoimmune disorders 243
16 Cancer the fatigue : insights from studies of women treated for breast cancer 265
17 Psychoneuroimmunology and fatigue 281
18 Rehabilitation and treatment of fatigue 301
19 Fatigue : its definition, its study, and its future 319
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