Fatty Acid and Lipotoxicity in Obesity and Diabetes / Edition 1

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Overview

The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle.

This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and β cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.

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Editorial Reviews

Doody's Review Service
Reviewer: Matthew J Brady, Ph.D.(University of Chicago Medical Center)
Description: This book collects the oral presentations and subsequent audience discussions at a symposium on fatty acids and lipotoxicity in obesity and diabetes held in Tsinghua, China in the fall of 2006.
Purpose: The purpose is to provide a written transcript of all the oral scientific presentations and follow-up discussions at the meeting.
Audience: The appropriate audience for this book would be scientific researchers in any area of fatty acid and energy metabolism, and graduate, medical, and undergraduate students with an interest in this topic. The book is accessible and thus would also be appropriate for healthcare providers with an interest in obesity/diabetes.
Features: The symposium and the book largely focus on the control of lipid metabolism, and the molecular and metabolic links between the development of obesity and systemic insulin resistance. There are numerous strengths to this collection of scientific talks. The presenters are all acknowledged experts in their respective fields and have provided excellent summaries of their respective laboratory research in context of the larger field. The question/answer section at the end of each chapter is especially informative, as readers are able to see other opinions on the topic as well as explore the unresolved areas requiring further investigation. In particular, since the people asking questions were also the other speakers in the symposium, links between the different talks and subject areas are often made, which provides a terrific coherence to the entire book. Finally, the book is exceptionally easy to read since the topics had to be prepared as oral presentations.
Assessment: This book will be an excellent resource for either beginning students or more established investigators in the field. The speakers are all top-notch researchers who gave clear and informative presentations. The integrative nature of the follow-up discussions and the excellent insights provided by the chair of the meeting throughout give the book an unusual coherence and consistency that is often lacking in broad, general reviews.
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Product Details

  • ISBN-13: 9780470057643
  • Publisher: Wiley
  • Publication date: 1/18/2008
  • Series: Novartis Foundation Symposia Series , #686
  • Edition number: 1
  • Pages: 222
  • Product dimensions: 6.26 (w) x 9.21 (h) x 0.63 (d)

Meet the Author

The Novartis Foundation is an international scientific and educational charity, which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
Chairman: Bruce Spiegelman.

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Table of Contents

Symposium on Fatty acids and lipotoxicity in obesity and diabetes, held at Tsinghua University, Beijing, China, 17–19 October 2006.

Editors: Gregory Bock (Organizer) and Jamie Goode.

This symposium is based on a proposal made by Peng Li.

Bruce M. Spiegelman - Chair’s introduction.

Bruce M. Spiegelman - Transcriptional control of energy homeostasis through the PGC1 coactivators.
Discussion.

Stephen O’Rahilly -  Human obesity and insulin resistance: lessons from experiments of nature.
Discussion.

Deborah M. Muoio and Timothy R. Koves - Lipid-induced metabolic dysfunction in skeletal muscle.
Discussion.

Alan D. Attie, Matthew T. Flowers, Jessica B. Flowers, Albert K. Groen, Folkert Kuipers and James M. Ntambi - Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes.
Discussion.

Karen Reue - The role of lipin 1 in adipogenesis and lipid metabolism. Discussion.

David Carling - The role of the AMP-activated protein kinase in the regulation of energy homeostasis.
Discussion.

Gökhan S. Hotamisligil - Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes.
Discussion.

Ira Tabas, Tracie Seimon, Jerry Arellano, Yankun Li, Fabien Forcheron, Dongying Cui, Seongah Han, Chien-Ping Liang, Alan Tall and Domenico Accili - The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis.
Discussion.

Sandra Lobo and David A. Bernlohr - Fatty acid transport in adipocytes and the development of insulin resistance.
Discussion.

Paul N. Black and Concetta C. DiRusso - Vectorial acylation: linking fatty acid transport and activation to metabolic trafficking.
Discussion. 

Günther Daum, Andrea Wagner, Tibor Czabany, Karlheinz Grillitsch and Karin Athenstaedt - Lipid storage and mobilization pathways in yeast.
Discussion. 

John Zhong Li and Peng Li - Cide proteins and the development of obesity.  Discussion.

General discussion I.
Visualizing brown adipose tissue with FDG-PET.

Takashi Kadowaki, Toshimasa Yamauchi, Naoto Kubota, Kazuo Hara and Kohjiro Ueki - Adiponectin and adiponectin receptors in obesity-linked insulin resistance.
Discussion.

Gabriel Pascual, Amy L. Sullivan, Sumito Ogawa, Amir Gamliel, Valentina Perissi, Michael G. Rosenfeld and Christopher K. Glass -Anti-inflammatory and antidiabetic roles of PPARγ.
Discussion.

Final discussion.
Nutrition, ageing and lipotoxicity.

Index of contributors.

Subject index.

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