Felix d`Herelle and the Origins of Molecular Biology

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Overview

A self-taught scientist determined to bring science out of the laboratory and into the practical arena, French-Canadian Felix d'Herelle (1873-1949) made history in two different fields of biology. Not only was he first to demonstrate the use and application of bacteria for biological control of insect pests, he also became a seminal figure in the history of molecular biology. This book is the first full biography of d'Herelle, a complex figure who emulated Louis Pasteur and influenced the course of twentieth-century biology, yet remained a controversial outsider to the scientific community.
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Editorial Reviews

Association of American Publishers, Professional/Scholarly Publishing Division - Scholarly Publishing Annual Award

Awarded an honorable mention for the 1999 Professional/Scholarly Publishing Annual Award in the Biological Science category given by the Association of American Publisher.
New England Journal of Medicine
This book, the only contemporary study of d'Herelle, will be of interest to historians of science and of medicine, sociologists, and anyone who is interested in the origins and growth of the biomedical revolution of the 20th century. Notwithstanding the value of traditional antibiotics, the current dangerous increase in bacterial resistance to antibiotics may lead to a resumption of the development of the discarded bacteriophage-based therapies. If this happens, Felix d'Herelle, the founder of "phagology," will be granted greater respect and attention and will enter the hall of fame for microbe hunters.
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Product Details

  • ISBN-13: 9780300071276
  • Publisher: Yale University Press
  • Publication date: 6/28/1999
  • Edition description: New Edition
  • Pages: 248
  • Product dimensions: 6.40 (w) x 9.30 (h) x 0.70 (d)

Table of Contents

Preface
Acknowledgments
1 Peregrinations of Youth 1
2 Fermentations: Guatemala and Mexico 11
3 Epizootics: Locusts in Argentina and Algeria 30
4 Bacteriophage Discovered 47
5 Reaction and Controversy 60
6 The Nature of Phage: Microbe or Enzyme? 82
7 The Origin of Life: Colloids and Protobes 97
8 The Hope of Phage Therapy 108
9 Fighting Cholera and Plague in India 125
10 Bacterial Mutations and Phage Research at Yale 145
11 To Tiflis and Back 161
12 Reflections and Legacies 173
Appendix "On an Invisible Microbe Antagonistic to the Dysentery Bacillus" ("Sur un microbe invisible antagoniste des bacilles dysenteriques") by Felix d'Herelle (1917) 185
Notes 187
Bibliography 207
Index 225
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