Fetal and Neonatal Physiology, 2-Volume Set

by Richard Polin MD, Steven H. Abman MD, David H. Rowitch MD ScD FMedSci, William Benitz MD

Overview

Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this 2-volume resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice.

The 5^th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner.

• Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants.
• Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology.
• Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.

• Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices.
• Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors.
• 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis.
• New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place.
• In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.

Product Details

ISBN-13:	9780323352147
Publisher:	Elsevier Health Sciences
Publication date:	07/01/2016
Edition description:	New Edition
Pages:	1928
Product dimensions:	9.60(w) x 11.70(h) x 4.30(d)

About the Author

Richard Polin is William T. Speck Professor and Vice-Chair of Pediatrics, Division of Neonatology, Vagelos College of Physicians and Surgeons at Columbia University Irving Medical Center, Morgan Stanley Children’s Hospital, New York-Presbyterian, New York.

Table of Contents

Section I - Genetics and Embryology

1. Basic Genetic Principles
2. Prenatal Diagnosis
3. Basic Embryology
4. Regulation of Embryogenesis
5. The Extracellular Matrix in Development
6. Stem Cell Biology
7. Apoptotic Cell Death
8. Angiogenesis
9. Epigenetics

Section II - Placenta and Intrauterine Environment

10. Placental Development
11. Regulation of the Placental Circulation
12. Mechanisms of Transfer Across the Human Placenta
13. Endocrine and Paracrine Function of the Human Placenta
14. Fetal and Maternal Responses to Intrauterine Infection
15. Fetal Origins of Adult Disease: A Classic Hypothesis with New Relevance
16. Physiologic Effects of Multiple Pregnancy on Mother and Fetus
17. Placental function in intrauterine growth restriction

Section III - Developmental Pharmacology and Pharmacokinetics

18. Basic Pharmacologic Principles
19. Principles of Pharmacokinetics
20. Physicochemical and Structural Properties Regulating Placental Drug Transfer
21. Pharmacogenetics
22. Drug Distribution in Fetal Life
23. Drug Transfer During Breastfeeding

Section IV - Intrauterine and Postnatal Growth

24. Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction
25. Endocrine Factors Affecting Neonatal Growth
26. Human Milk Composition and Function in the Infant
27. Physiology of Lactation

Section V - Perinatal Iron, Mineral, and Vitamin Metabolism

28. Fetal and Neonatal Iron Metabolism
29. Neonatal Calcium, Phosphorus, and Magnesium Homeostasis
30. Zinc in the Fetus and Neonate
31. Vitamin A Metabolism in the Fetus and Neonate
32. Vitamin E Metabolism in the Fetus and Newborn Infant
33. Vitamin K Metabolism in the Fetus and Neonate

Section VI - Lipid Metabolism

34. Maternal-Fetal Transfer of Lipid Metabolites
35. Brown Adipose Tissue: Development and Function
36. Lipids as an Energy Source for the Premature and Full-Term Neonate
37. Ketone Body Production and Metabolism in the Fetus and Neonate
38. Long-Chain Fatty Acids in the Developing Retina and Brain

Section VII - Carbohydrate Metabolism

39. Metabolism of Glucose and Methods of Investigation in the Fetus and Newborn
40. Carbohydrate Metabolism During Pregnancy
41. Oxygen Consumption and General Carbohydrate Metabolism of the Fetus
42. Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period
43. Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development

Section VIII - Protein Metabolism

44. General Concepts of Protein Metabolism
45. Fetal Requirements and Placental Transfer of Nitrogenous Compounds

Section IX - Thermoregulation

46. Temperature Control in Newborn Infants
47. Responses of the Fetus and Neonate to Hypothermia

Section X - Skin

48. Structure and Development of Skin and Cutaneous Appendages
49. Physiologic Development of the Skin

Section XI - Fetal and Neonatal Cardiovascular Physiology

50. Cardiovascular Development
51. Developmental Electrophysiology in the Fetus and Neonate
52. Developmental Biology of the Pulmonary Vasculature
53. Development of the Gastrointestinal Circulation in the Fetus and Newborn
54. Physiology of Congenital Heart Disease in the Neonate
55. Neural Regulation of Blood Pressure During Fetal and Newborn Life
56. Developmental Effects on Fetal Circulation
57. Mechanisms Regulating Closure of the Ductus Arteriosus
58. Umbilical Circulation
59. Fetal and Placental Circulation During Labor
60. Physiology of Resuscitation

Section XII - The Lung

61. Normal and Abnormal Structural Development of the Lung
62. Regulation of Alveolarization
63. Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth
64. Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis
65. Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung
66. Upper Airway Structure: Function, Regulation, and Development
67. Regulation of Lower Airway Function
68. Functional Development of Respiratory Muscles
69. Mechanics of Breathing
70. Pulmonary Gas Exchange in the Developing Lung
71. Oxygen Transport and Delivery
72. Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate
73. Basic Mechanisms of Oxygen Sensing and Response to Hypoxia
74. Evaluation of Pulmonary Function in the Neonate
75. Mechanisms of Neonatal Lung Injury
76. Impaired Lung Growth After Injury in Premature Lung
77. Antenatal Factors That Influence Postnatal Lung Development and Injury
78. Regulation of Pulmonary Circulation

Section XIII - Surfactant

79. Historical Perspective
80. Composition of Pulmonary Surfactant Lipids and Proteins
81. Structure And Development of Alveolar Epithelial Cells
82. Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion
83. Hormonal Therapy for Prevention of Respiratory Distress Syndrome
84. Surfactant Treatment
85. Genetics and Physiology of Surfactant Protein Deficiencies

Section XIV - Physiology of Gastrointestinal Tract in the Fetus and Neonate

86. Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development
87. Organogenesis of the Gastrointestinal Tract
88. Development of the Enteric Nervous System
89. Development of Gastric Secretory Function
90. Development of Gastrointestinal Motility
91. Development of the Exocrine Pancreas
92. Digestive-Absorption Functions in Fetuses, Infants, and Children
93. Development of the Intestinal Microbiome

Section XV - Liver and Bilirubin Metabolism

94. Organogenesis and Histologic Development of the Liver
95. Bile Acid Metabolism During Development
96. Neonatal Bilirubin Metabolism
97. Hereditary Contribution to Neonatal Hyperbilirubinemia
98. Mechanisms of Action of Phototherapy for Neonatal Hyperbilirubinemia

Section XVI - The Kidney

99. Embryogenesis and Anatomic Development of the Kidney
100. Functional Development of the Kidney in Utero
101. Development and Regulation of Renal Blood flow in the Neonate
102. Development of the Renin-Angiotensin System
103. Postnatal Development of Glomerular Filtration Rate in Neonates
104. Renal Transport of Sodium During Early Development
105. Potassium Homeostasis in the Fetus and Neonate
106. Role of the Kidney in Calcium and Phosphorus Homeostasis
107. Transport of Amino Acids in the Fetus and Neonate
108. Developmental Aspects of Organic Acid Transport
109. Concentration and Dilution of the Urine
110. Development of Acidification Mechanisms in the Fetus and Neonate
111. Response to Nephron Loss in Early Development

Section XVII - Fluid and Electrolyte Metabolism

112. Fluid Distribution in the Fetus and Neonate
113. Regulation of Acid-Base Balance in the Fetus and Neonate

Section XVIII - Developmental Hematopoiesis

114. Developmental Biology of Stem Cells: From the Embryo to the Adult
115. Developmental Granulocytopoiesis
116. Developmental Erythropoiesis
117. Developmental Megakaryocytopoiesis

Section XIX - Hemostasis

118. Developmental Hemostasis
119. Platelet–Vessel Wall Interactions

Section XX - Developmental Immunobiology

120. Host Defense Mechanisms Against Bacteria
121. Host-Fungi Interactions Relevant to the Newborn Infant
122. Host Defense Mechanisms Against Viruses
123. T-Cell Development
124. B-Cell Development
125. Mononuclear Phagocyte System
126. Normal and Abnormal Neutrophil Physiology in the Newborn
127. The Complement System of the Fetus and Newborn
128. Cytokines and Inflammatory Response in the Fetus and Neonate
129. Immunology of Human Milk and Host Immunity
130. Neonatal Pulmonary Host Defense

Section XXI - Neurology

131. Development of the Nervous System
132. Development of the Blood-Brain Barrier
133. Trophic Factor and Nutritional and Hormonal Regulation of Brain Development
134. Intraventricular Hemorrhage in the Neonate
135. Cerebellar Development – an Impact of Preterm Birth and Co-Morbidities
136. Electroencephalography in the Premature and Full-Term Infant
137. Developmental Aspects of Pain

Section XXII - Special Sensory Systems in the Fetus and Neonate

138. Early Development of the Human Auditory System
139. Development of Taste and Smell in the Neonate

Section XXIII - Orthopedics

140. The Growth Plate: Embryologic Origin, Structure, and Function
141. Ontogenesis of Striated Muscle

Section XXIV - Endocrine Function

142. Hypothalamus: Neuroendometabolic Center
143. Growth Factor Regulation of Fetal Growth
144. Growth Hormone in the Fetus and Newborn
145. Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn
146. Development of the Corticotropin-Releasing Hormone–Corticotropin System in the Mammalian Fetus
147. Fetal and Neonatal Adrenocortical Physiology
148. Fetal and Neonatal Thyroid Physiology

Section XXV - Ovary and Testis

149. Genetics of Sex Determination and Differentiation
150. Differentiation of the Ovary
151. Testicular Development and Descent

Section XXVI - Pathophysiology of Neonatal Diseases

152. Pathophysiology of Neonatal sepsis
153. Pathophysiology of Hypoglycemia in the Neonate
154. Pathophysiology of Cardiomyopathies
155. Pathophysiology of Persistent pulmonary hypertension of the newborn
156. Pathophysiology of Shock in the Fetus and Neonate
157. Pathophysiology of Apnea of Prematurity
158. Pathophysiology of Respiratory Distress Syndrome
159. Pathophysiology of Meconium Aspiration Syndrome
160. Pathophysiology of Bronchopulmonary Dysplasia
161. Pathophysiology of Ventilator Dependent Infants
162. Pathophysiology of Gastroesophageal Reflux
163. Pathophysiology of Neonatal Necrotizing Enterocolitis
164. Pathophysiology of Kernicterus
165. Pathophysiology of neonatal acute kidney injury
166. Pathophysiology of Edema
167. Pathophysiology of Retinopathy of Prematurity
168. Pathophysiology of Hypoxic-ischemic Brain Injury
169. Pathophysiology of Neonatal White Matter Injury
170. Pathophysiology of Meningitis
171. Pathophysiology of Neural Tube Defects
172. Pathophysiology of Preeclampsia
173. Pathophysiology of Preterm Birth
174. Pathophysiology of Chorioamnionitis

What People are Saying About This

From the Publisher

The most complete fetal and neonatal physiology text available

Editorial Reviews

"There are no comparable books in this field and this one should hold a unique place as a reference for both physician scientists and clinicians. The new section on the pathophysiology of neonatal disease adds value to this already incomparable text."

-Jay P. Goldsmith, MD (Tulane University School of Medicine), Doody’s Score: 96 - 4 Stars!

From the Publisher