BN.com Gift Guide

The Fetal and Neonatal Pulmonary Circulation / Edition 1

Hardcover (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $24.27
Usually ships in 1-2 business days
(Save 87%)
Other sellers (Hardcover)
  • All (14) from $24.27   
  • New (8) from $90.78   
  • Used (6) from $0.00   

Overview

Birth is a sudden, traumatic transition of environments. Once the placental oxygen supply ceases, the foetus has only minutes to establish pulmonary oxygen transport, which requires not only inflation of the lungs, but also sudden and sustained changes in the lung circulation. Not long ago, research in this field was largely restricted to morphology and physiology. Now the powerful new tools of cellular and molecular biology have begun to shed light on the physiological processes in the developing lung and its supporting vasculature.

In 22 chapters, three main sections explore lung growth and development, vascular cell growth and differentiation, and the mechanisms of hemodynamic control in the neonate; extensive illustrations give a comprehensive picture of pulmonary circulatory development. Factors controlling vasculogenesis and angiogenesis are described by the scientists who pioneered the field. Similarly, the intracellular signaling cascades that determine proliferation or growth inhibition of fibroblasts, smooth muscle cells, and endothelial cells are also presented in an understandable manner. Finally, the role of substances, such as nitric oxide and endothelin, that control the hemodynamics of the fetal and neonatal circulations are discussed in detail, particularly in relation to the changes occurring at birth.

This book will inform basic scientists as well as the clinician and student, and should be of particular interest to pediatric cardiologists, pulmonary medicine physicians, and vascular biologists.

The book contains black-and-white illustrations.

In 22 chapters, three main sections explore lung growth and development, vascular cell growth and differentiation, and the mechanisms of hemodynamic control in the neonate; extensive illustrations give a comprehensive picture of pulmonary circulatory development. Factors controlling vascular- and angiogenesis are described by the scientists who pioneered the field. Similarly, the intracellular signaling cascades that determine proliferation or growth inhibition of fibroblasts, smooth muscle cells, and endothelial cells are also presented in an understandable manner. Finally, the role of substances, such as nitric oxide and endothelin, that control the hemodynamics of the fetal and neonatal circulations are discussed in detail, particularly in relation to the changes occurring at birth. This book will inform basic scientists as well as the clinician and student, and should be of particular interest to pediatric cardiologists, pulmonary medicine physicians, and vascular biologists.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Robin H. Steinhorn, MD (Northwestern University Feinberg School of Medicine)
Description: This muliauthored text is a part of the American Heart Association Monograph Series. Experts in pulmonary vascular growth and remodeling during the fetal and newborn period are featured.
Purpose: The purpose is to summarize current research related to the developing pulmonary circulation. By doing so, the editors intend to inform the reader, as well as provide a benchmark for future progress in the field.
Audience: The editors state that the book is written for the basic scientist as well as the clinician and student. Given the detail provided in the book, I believe it will be of particular interest to basic scientists and clinician-investigators in pediatric pulmonology, pediatric cardiology, neonatology, and obstetricians specializing in perinatology. The contributors are all top-notch experts in their respective fields.
Features: The book is divided into three main sections, which follow a natural progression in emphasis from early lung development and vasculogenesis, to vascular cell growth and differentiation, to pulmonary vascular changes that occur as the fetus becomes a newborn. In each section a topic is examined in exceptional detail, with focus on cell types, mechanical forces, and potential signaling mechanisms responsible for the dramatic changes in pulmonary vascular resistance that occur during fetal and newborn life. Important information about abnormal development and stimuli are included throughout. The book is well illustrated with figures demonstrating histology, scientific results, and valuable diagrams of proposed mechanisms of vascular control.
Assessment: The topic of pulmonary vascular development during fetal and newborn life is often "buried" in more global pulmonary texts. This monograph is a welcome reversal in emphasis. It is a unique and valuable text, providing the investigator and clinician with "one-stop shopping" for timely, detailed, and important information about pulmonary vascular development during fetal and newborn life.
From the Publisher
"Four Stars! ****
"The Contributors are all top-notch experts in their respective fields...In each section a topic is examined in exceptional detail.
"...a unique and valuable text, providing the investigator and clinician with ‘one-stop shopping’ for timely, detailed, and important information about pulmonary vascular development during fetal and newborn life."

Doody’s Review Service

"...a most excellent work, The Fetal and Neonatal Pulmonary Circulation aims to "inform the basic scientist as well as the clinician and student, and to provide a benchmark in the field as we approach the next millennium." The resulting text serves these ambitions superbly.

"The editors have selected an impressive group of experts to contribute chapters which cover a wide range of topics, from the history of fetal and neonatal pulmonary vascular physiology, to vascular-cell growth and differentiation, to the factors and disorders, including congenital diaphragmatic hernia, which affect pulmonary hemodynamics in the newborn.

"...In an era in which the distance between the basic scientist and busy clinician seems to be ever wider, I am particularly impressed by the way in which basic science and clinical medicine fuse into a continuum in this excellent book. The Fetal and Neonatal Pulmonary Circulation shows that when we try to work together, we can. It must be the definitive work in the area. More of the same in other areas of medicine please."

The Lancet

Robin H. Steinhorn
This muliauthored text is a part of the American Heart Association Monograph Series. Experts in pulmonary vascular growth and remodeling during the fetal and newborn period are featured. The purpose is to summarize current research related to the developing pulmonary circulation. By doing so, the editors intend to inform the reader, as well as provide a benchmark for future progress in the field. The editors state that the book is written for the basic scientist as well as the clinician and student. Given the detail provided in the book, I believe it will be of particular interest to basic scientists and clinician-investigators in pediatric pulmonology, pediatric cardiology, neonatology, and obstetricians specializing in perinatology. The contributors are all top-notch experts in their respective fields. The book is divided into three main sections, which follow a natural progression in emphasis from early lung development and vasculogenesis, to vascular cell growth and differentiation, to pulmonary vascular changes that occur as the fetus becomes a newborn. In each section a topic is examined in exceptional detail, with focus on cell types, mechanical forces, and potential signaling mechanisms responsible for the dramatic changes in pulmonary vascular resistance that occur during fetal and newborn life. Important information about abnormal development and stimuli are included throughout. The book is well illustrated with figures demonstrating histology, scientific results, and valuable diagrams of proposed mechanisms of vascular control. The topic of pulmonary vascular development during fetal and newborn life is often "buried" in more global pulmonary texts. This monograph is awelcome reversal in emphasis. It is a unique and valuable text, providing the investigator and clinician with "one-stop shopping" for timely, detailed, and important information about pulmonary vascular development during fetal and newborn life.
Booknews
Specialists in cardiovascular and pulmonary research as well as pediatric specialists from around the world have contributed to this volume to examine the status of the field of fetal and neonatal pulmonary circulations. The editors list four main areas of focus: 1) the cellular and molecular factors controlling vasculogenesis; 2) the genetic and molecular factors responsible for vascular cell differentiation; 3) the role of the extracellular matrix in regulating vascular cell proliferation and activity; and 4) the mechanisms controlling tone in the transition at birth. Annotation c. Book News, Inc., Portland, OR (booknews.com)

4 Stars! from Doody
Read More Show Less

Product Details

  • ISBN-13: 9780879934392
  • Publisher: Wiley
  • Publication date: 6/16/2000
  • Series: American Heart Association Monograph Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 404
  • Product dimensions: 6.20 (w) x 9.30 (h) x 1.19 (d)

Table of Contents

Preface.

(E.K. Weir, S.L. Archer, J.T. Reeves).

Section I. Lung Growth and Development.

1. The Development of Concepts of the Ontogeny of the Pulmonary Circulation.

(A.M. Rudolph).

2. The de Novo Formation of Blood Vessels in the Early Embryo and in the Developing Lung. (C.J. Drake, C.D. Little).

3. Early Development of the Vascular System of the Mouse Lung: Ontogeny of Endothelial Cell Heterogeneity. (R. Auerbach, O. Mierzoeva, K.C. Meyer).

4. Structural Elements of Human Fetal and Neonatal Lung Vascular Development. (D.E. deMello).

Section II. Vascular Cell Growth and Differentiation.

5. Contribution of the Adventitial Fibroblast to Pulmonary Vascular Disease.

(K.R. Stenmark, M. Das, D. Bouchey, E.C. Dempsey).

6. The Role of Thrombospondins 1 and 2 in Vascular Development.

(L.C. Armstrong, T.R. Kyriakides, P. Bornstein).

7. Elastic Fiber Proteins in Pulmonary Vascular Development.

(J.M.W. Hausladen, R.P. Mecham).

8. Proteolytic Modulation of the Extracellular Matrix. (M. Rabinovitch).

9. Signal Transduction Kinases in the Regulation of Matrix Metalloproteinase-9 Expression in Vascular Smooth Muscle Cells. (A. Cho, M.A. Reidy).

10. Transcription Factors Controlling Cellular Proliferation During Vascular Repair. (R.C. Smith, T. Mano, K. Walsh).

11. Perlecan Heparan Sulfates in the Control of Vascular Smooth Muscle Cell Proliferation. (M.C.M. Weiser-Evans, K.R. Stenmark).

12. B-Myb Represses Collagen Gene Expression in Bovine Vascular Smooth Muscle Cells. (K.E. Kypreos, D.J. Marhamati, M.A. Nugent, G.E. Sonenshein).

13. Mechanical Forces in Vascular Growth and Development. (B.L. Langille).

Section III. Mechanisms of Hemodynamic Control in the Neonate.

14. Lung Arteriolar Endothelial Cell Proliferation at Birth: Possible Roles of Stretch and Hypoxia. (J.T. Reeves).

15. Physiologic Roles of Nitric Oxide in the Perinatal Pulmonary Circulation.

(S.H. Abman, J.P. Kinsella, T.A. Parker, L. Storme, T.D. Le Cras).

16. Regulation of Endothelial Nitric Oxide Synthase Expression in the Developing Lung. (P.W. Shaul).

17. The Role of Endothelin in Perinatal Pulmonary Vasoregulation.

(D.D. Ivy, S.H. Abman).

18. O2-Sensitive K+ Channel Activity in the Ovine Pulmonary Circulation Shifts with Maturation. (D.N. Cornfield, H.L. Reeve, E.K. Weir).

19. Regulation of Ion Channels in the Ductus Arteriosus. (H.L. Reeve, E.K. Weir).

20. Cytochrome P450 in the Contractile Tone of the Ductus Arteriosus: Regulatory and Effector Mechanisms. (F. Coceani).

21. Maturational Changes in the Human Pulmonary Vascular Resistance.

(J.C. Huhta, J. Rasanen).

22. The Pulmonary Vasculature in Congenital Diaphragmatic Hernia.

(R. Tibboel, S.M.K. Shehata, A.H. Guldemeester).

Index.

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)