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Doody's Review ServiceReviewer: Robin H. Steinhorn, MD (Northwestern University Feinberg School of Medicine)
Description: This muliauthored text is a part of the American Heart Association Monograph Series. Experts in pulmonary vascular growth and remodeling during the fetal and newborn period are featured.
Purpose: The purpose is to summarize current research related to the developing pulmonary circulation. By doing so, the editors intend to inform the reader, as well as provide a benchmark for future progress in the field.
Audience: The editors state that the book is written for the basic scientist as well as the clinician and student. Given the detail provided in the book, I believe it will be of particular interest to basic scientists and clinician-investigators in pediatric pulmonology, pediatric cardiology, neonatology, and obstetricians specializing in perinatology. The contributors are all top-notch experts in their respective fields.
Features: The book is divided into three main sections, which follow a natural progression in emphasis from early lung development and vasculogenesis, to vascular cell growth and differentiation, to pulmonary vascular changes that occur as the fetus becomes a newborn. In each section a topic is examined in exceptional detail, with focus on cell types, mechanical forces, and potential signaling mechanisms responsible for the dramatic changes in pulmonary vascular resistance that occur during fetal and newborn life. Important information about abnormal development and stimuli are included throughout. The book is well illustrated with figures demonstrating histology, scientific results, and valuable diagrams of proposed mechanisms of vascular control.
Assessment: The topic of pulmonary vascular development during fetal and newborn life is often "buried" in more global pulmonary texts. This monograph is a welcome reversal in emphasis. It is a unique and valuable text, providing the investigator and clinician with "one-stop shopping" for timely, detailed, and important information about pulmonary vascular development during fetal and newborn life.