Fetal Islet Transplantation / Edition 1

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Editorial Reviews

Doody's Review Service
Reviewer: Daniel C. Brennan, MD (Washington University School of Medicine)
Description: This book contains selected proceedings from the Second International Sansum Symposium on Fetal Islet Transplantation that was held in October 1994 in honor of Dr. Paul Lacy, one of the preeminent investigators in islet transplantation.
Purpose: The book seeks to provide the foundation for anyone interested in the areas of fetal islet growth, differentiation, and immunology as well as transplantation. The objectives are laudable, although a separate chapter on the history or an expanded overview on fetal and islet cell transplantation in general would have gone a long way to providing a better foundation. However, such an overview was probably unnecessary for the participants of the symposium from which these selections were taken.
Audience: Although it is directly stated that the book is for anyone interested in the area of fetal islet transplantation, the nature of the symposia format determines that the audience will be those who are quite immersed in the field already.
Features: Only a cursory and one-sided discussion of the complex ethical issues involved in human fetal tissue research in general is presented. Understandably, the participants of the symposia would need little convincing for the utility or morality of this research. Thus, the book would not be useful to anyone to help clarify the fundamental ethical dilemmas of the use of human fetal tissue to ameliorate human disease.
Assessment: The selections provide a good introduction to the issue of fetal islet transplant research in particular and islet transplantation in general. The selections are brief, well written, and easy to read. The conclusions remain surprisingly optimistic despite the limited success after more than 25 years of research initiated in the early 1970s by Dr. Lacy.
Daniel C. Brennan
This book contains selected proceedings from the Second International Sansum Symposium on Fetal Islet Transplantation that was held in October 1994 in honor of Dr. Paul Lacy, one of the preeminent investigators in islet transplantation. The book seeks to provide the foundation for anyone interested in the areas of fetal islet growth, differentiation, and immunology as well as transplantation. The objectives are laudable, although a separate chapter on the history or an expanded overview on fetal and islet cell transplantation in general would have gone a long way to providing a better foundation. However, such an overview was probably unnecessary for the participants of the symposium from which these selections were taken. Although it is directly stated that the book is for anyone interested in the area of fetal islet transplantation, the nature of the symposia format determines that the audience will be those who are quite immersed in the field already. Only a cursory and one-sided discussion of the complex ethical issues involved in human fetal tissue research in general is presented. Understandably, the participants of the symposia would need little convincing for the utility or morality of this research. Thus, the book would not be useful to anyone to help clarify the fundamental ethical dilemmas of the use of human fetal tissue to ameliorate human disease. The selections provide a good introduction to the issue of fetal islet transplant research in particular and islet transplantation in general. The selections are brief, well written, and easy to read. The conclusions remain surprisingly optimistic despite the limited success after more than 25 years of research initiated in theearly 1970s by Dr. Lacy.
Booknews
Proceedings of the October 1994 symposium at Sansum Medical Research Foundation in Santa Barbara, CA, focus on the use of fetal islet tissue in controlling diabetes and repairing islets that have been damaged by autoimmune disease. Papers detail research on fetal islet growth, differentiation, immunology, and transplantation. Other topics include fetal islet transplantation and pregnancy, and networking for the collection of fetal islet tissues. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780306450662
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 1/28/1995
  • Series: The Language of Science Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 202
  • Product dimensions: 6.70 (w) x 10.16 (h) x 0.39 (d)

Table of Contents

1 Protocols for Enhancing Function of Fetal Islets in Vitro and following Transplantation 1
2 Expression of Two Non-Allelic REG Genes in the Developing Human Pancreas: Effects in Vitro of Nicotinamide and Maternal Growth Factors 15
3 Preparation of Fetal Islets for Transplantation: Importance of Growth Factors 27
4 Studies of Fetal Porcine Islet-like Cell Clusters - A Tissue Source for Xenotransplantation in Insulin-Dependent Diabetes Mellitus? 37
5 Basic Biology of Pig Fetal Pancreas and Its Use as an Allograft 51
6 Combined Transplantation of Adult and Fetal Islets for Improvement of Graft Function: Prospective Approach for Diabetes Treatment 69
7 Studies on Pretreatment of Human Fetal Islet in Vitro and Clinical Islet Transplantation in China 77
8 The Use of Human Fetal Islet Tissue for Adjunctive Treatment in Insulin-Dependent Diabetic Patients: The Case for "Partial Success" 87
9 Long-Term Studies with Cultured and Cryopreserved Human Fetal Islets for Islet Transplantation in Hungary 99
10 Fetal Islet Transplantation and Pregnancy 113
11 Encapsulated Human Islet Transplant Trials in Type I Diabetic Patients 137
12 Optimal Surveillance of Diabetic Eye Disease 151
13 Detection of Pancreatic Islet Transplant Rejection 161
14 Networking for the Collection of Fetal Islet Tissues 175
15 Consensus Session Summary: Second International Symposium on Fetal Islet Transplantation 181
Contributors 185
Index 189
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