Fetal Nutrition and Adult Disease: Programming of Chronic Disease Through Fetal Exposure to Undernutrition

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Overview

Over the last decade, epidemiological studies have suggested that the risk of coronary heart disease, stroke mortality and hypertension is, in part, related to the environment encountered during fetal life. In particular, maternal undernutrition during pregnancy has been highlighted as a causal factor in the long-term programming of disease risk. This book, which brings together the perspectives of leading researchers from Europe, the USA and Australasia, provides the reader with a detailed account of the evidence for and against the nutritional programming of human disease, and considers the biological basis of programming. The book addresses a topic of great current interest and consists of three sections: programming the fetus, programming human disease, and the biological basis of nutritional programming.

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Editorial Reviews

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"The book is written in an extremely readable style, which is credit to the many multi-national authors. It has some excellent chapters that raise current issues in modern medicine and public health."
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Product Details

  • ISBN-13: 9780851998213
  • Publisher: CAB International North America
  • Publication date: 9/12/2004
  • Series: Frontiers in Nutritional Science Series , #2
  • Pages: 416
  • Product dimensions: 6.87 (w) x 9.75 (h) x 1.00 (d)

Table of Contents

SECTION 1: PROGRAMMING THE FETUS

• Introduction: Fetal programming of adult disease: an overview

• The nutritional basis of the fetal origins of adult disease

• Fetal hypoxia, placental function and fetal development

SECTION 2: PROGRAMMING HUMAN DISEASE

• The early life origins of cardiovascular disease: cohort studies

• Associations between fetal growth and adult disease: are they causal?

• Experimental models of hypertension and cardiovascular disease

• Associations between fetal and infant growth and non-insulin-dependent diabetes

• Programming of diabetes: experimental models

• Associations between human obesity and growth restriction during intrauterine life

• Associations between maternal nutrition in pregnancy and later adiposity in animals

• Renal disease and fetal undernutrition, Lori Woods, Oregon Health and Science University, USA

• Perinatal determinants of atopic disease

• Fetal programming of immune function

SECTION 3: BIOLOGICAL BASIS OF NUTRITIONAL PROGRAMMING

• Programming in the pre-implantation embryo

• Endocrine responses to fetal undernutrition: the IGF-Growth Hormone axis

• Impact of intrauterine exposure to glucocorticoids upon fetal development

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