Fgf Signalling In Vertebrate Development

Overview

This review will explore examples from several vertebrate model organisms and include discussions of the role of fibroblast growth factors (FGF) signaling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development and the establishment of right-left asymmetry. The FGF represent one of the relatively few families of extracellular signaling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple...
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Overview

This review will explore examples from several vertebrate model organisms and include discussions of the role of fibroblast growth factors (FGF) signaling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development and the establishment of right-left asymmetry. The FGF represent one of the relatively few families of extracellular signaling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple processes in both protostome and deuterostome groups. Given the wide range of regulatory roles attributed to the FGFs, it is perhaps not surprising that mis-regulation of this signaling pathway has been implicated in a number of human disease conditions. The focus of the present review is to look at the fundamental components of the FGF pathway and illustrate how this highly conserved regulatory cassette has been deployed to regulate multiple, diverse processes during vertebrate development.
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Product Details

Table of Contents

Introduction 1

FGF Ligands 2

FGF Receptors 4

Heparan Sulphate Proteoglycans 6

FGF Signal Transduction 7

Regulators 9

Sulfatases and Sulfotransferases 9

Sprouty 10

MAPK Phosphatases 11

Sef 12

FLRT 12

Integration with Other Signalling Pathways 14

Mesoderm Induction 17

Neural Induction 22

FGF Signalling and Posterior Neural Patterning 26

FGF Signalling at the Isthmic Organizer 28

FGF Signalling at the Anterior Neural Ridge 31

Morphogenesis 33

Gastrulation 33

Inner Ear 35

Lateral Line 36

Pronephros 37

Branching Morphogenesis 37

The Developing Heart 39

Somitogenesis 40

FGF and Myogenesis 43

Limb Development 46

Apical Ectodermal Ridge 46

The ZPA Requires the AER and Vice Versa 48

FGF and Left-Right Asymmetry 50

Perspectives 54

References 55

About the Authors 75

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