Fighting Sudden Cardiac Death: A Worldwide Challenge / Edition 1

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This book analyzes sudden cardiac death from the multiple perspectives of world-renowned experts.

Fighting Sudden Cardiac Death: A Worldwide Challenge reviews the background of sudden cardiac death (SCD) in light of new advances in genetics, mechanisms of therapy, and prevention, thus providing the reader with a more unified view of SCD, a better understanding of the pathological mechanisms of SCD, and the tools needed to identify the appropriate treatment for patients at risk for a primary event.

Its 50 chapters incorporate expert findings on a wide variety of relevant subjects, ranging from cell to examination, from idiopathic arrhythmias and SCD in athletes to arrhythmogenic heart failure, from long QT syndrome to ventricular dysplasia, from prehospital resuscitation to very sophisticated implantable devices. In-depth discussions on the background, therapy and prevention of SCD serve to increase and improve the tools available to battle this "serial killer."

Cardiologists, electrophysiologists, and internists, both in clinical practice and in the laboratory, will find a great deal of valuable information in this book.

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Editorial Reviews

For cardiologists, electrophysiologists, and internists, specialists review the background of sudden cardiac death in light of developments in genetics, mechanisms of therapy, and prevention. The 50 short studies cover definition, epidemiology, and mechanisms; out-of- hospital death; the normal heart and sports; arrhythmogenic right ventricular dysplasia; repolarization; heart failure; pediatrics; etiologies; ischemia; markers in the era of revascularization; prevention; medical and non-medical therapy, and automatic implantable cardioverter-defibrillators. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780879934606
  • Publisher: Wiley
  • Publication date: 1/1/2000
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 724
  • Product dimensions: 6.30 (w) x 9.30 (h) x 1.50 (d)

Table of Contents






I. Definition, Epidemiology and Mechanisms.


1. Definitions and Epidemiology of Sudden Cardiac Death.

R.J. Myerburg et al.

2. The Classification of Sudden Death in Clinical Trials.

L.J.M.C. Jordens.

3. How Genetics May Help to Understand and Prevent Sudden Cardiac Death.

K. Schwartz.

4. Autonomic Nervous System and Sudden Cardiac Death.

H. Calkins.

5. Apoptosis and Sudden Cardiac Death.

Z. Mallat, B. Hugel, G. Leseche, J-M. Freyssinet, A. Tedgui.

6. Spatiotemporal Organization of Ventricular Fibrillation Increases during Global Ischemia in the Isolated Rabbit Heart.

J. Chen, R. Mandapati, O. Berenfeld, M. Mansour, J. Jalife.

7. The Role of Early Afterdepolarizations in Lethal Ventricular Arrhythmias.

R. Lazzara, B. Szabo.

8. Regional Differences in Electrophysiology of Ventricular Cells: Clinical Implications for Sudden Cardiac Death.

C. Antzelevitch.

9. Nonfibrillatory Sudden Cardiac Death: Role of Bradycardia.

J-J. Blanc, J. Mansourati.

10. Sudden Cardiac Death: The Pathology Perspective.

M. Davies.


II. Out of Hospital Sudden Cardiac Death.

11. Automated External Defibrillation in Europe.

L. Bossaert.

12. The Maastricht Study: A Plea for New Approaches to Improve Results of Out-of-Hospital Resuscitation.

H.J.J. Wellens, J. de Vreede-Swagemakers, A. Lousberg, A.M. Gorgels.

13. European Resuscitation Council Guidelines for Resuscitation of the Adult Cardiac Arrest Victim.

L. Bossaert.

14. Evidence-Based Guidelines in Resuscitation: From Experiment to Guidelines.

L.B. Becker.

III. Normal Heart, Sports, and Sudden Cardiac Death.


15. Sudden Cardiac Death in Young Athletes: Epidemiology, Screening, and Prevention.

B.J. Maron.

16. Idiopathic Ventricular Fibrillation.

S.G. Priori, L. Crotti.

17. Why Patients with Arrhythmogenic Right Ventricular Dysplasia Die Suddenly.

G. Fontaine, P. Fornes, Z. Mallat, F. Fontaliran, R. Frank.

18. Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: A Genetic or an Acquired Disease?.

D. Corrado, C. Basso, M. Valente, G. Thiene.

19. Therapies for Prevention of Sudden Cardiac Death in Arrhythmogenic Right Ventricular Cardiomyopathy.

T. Wichter, M. Borggrefe, D. Boecker, G. Breithardt.


V. Sudden Cardiac Death and Repolarization.

20. The Long QT Syndrome: From Genotype to Phenotype.

P.J. Schwartz.

21. Congenital Long QT Syndrome: Therapeutic Considerations Based on the International LQTS Registry.

A.J. Moss, W. Zareba.

22. Brugada Syndrome: From Genetics to Clinical Management.

P. Brugada, J. Brugada, R. Brugada, J. Tobin, C. Antzelevitch.


VI: Heart Failure.

23. Are There Specific Risk Markers of Sudden Cardiac Death in Heart Failure Patients?.

J.Y. Le Heuzey et al.

24. Sudden Cardiac Death in Idiopathic Dilated Cardiomyopathy.

P. Cosnay et al.

25. Mechanisms of Sudden Death in Hypertrophic Cardiomyopathy: Implications for Risk Stratification.

P. Sorajja, P.M. Elliott, W.J. McKenna.

26. Prevention of Sudden Cardiac Death in Hypertrophic Cardiomyopathies.

R. Cappato.

27. The Implantable Cardioverter-Defibrillator as a Bridge to Transplantation: Is it Worthwhile?.

A. Raviele.


VII: Pediatrics.

28. Neuromuscular Disorders and Sudden Death.

D. Duboc et al.

29. Sudden Cardiac Death After Surgery of Congenital Cardiac Diseases.

E. Villain.


VIII: Etiologies.

30. Sudden Death in Mitral Valve Prolapse.

J-P. Fauchier et al.

31. Sudden Death in Patients with Cardiac Conduction Disorders.

H.E. Kulbertus.

32. Myocarditis: An Underestimated Cause of Sudden Cardiac Death.

C. Basso, F. Calabrese, D. Corrado, G. Thiene.


IX: Ischemia and Sudden Cardiac Death.

33. Arrhythmias in Acute Ischemia.

M.J. Janse.

34. Mechanisms of Ventricular Arrhythmias in the Subacute and Late Post-Infarction Period.

N. El-Sherif, B. Huang, D.O. Kozhevnikov.


X: Markers of Sudden Cardiac Death in the Era of Revascularization.

35. Usefulness of Premature Ventricular Contractions and Late Potentials for Risk Stratification after Myocardial Infarction in the Era of Revascularization.

S. Kacet, C. Kouakam.

36. Baroreflex Sensitivity and Heart Rate Variability: State of the Art and Perspective.

M. Malik, I. Savelieva.

37. Markers of Sudden Cardiac Death. Clinical Usefulness of the QT Study: QT Duration, QT Dispersion, QT Dynamicity, and T-Wave Alternans.

A. Leenhardt, P. Maison Blanche, F. Extramiana, P. Milliez, P. Coumel.

38. Value of Programmed Ventricular Stimulation to Select Candidates at Risk for Sudden Cardiac Death.

E.N. Prystowsky.

39. Value of Left Ventricular Function Stratification.

K. Isaaz.

40. Nonsustained Ventricular Tachycardia: Prognostic and Therapeutic Considerations.

N. Saoudi, F. Anselme, M. Chalumeau, A. Savoure, A. Cribier.


XI: Prevention.

41. The Role of Stress in Sudden Death: Can it be Prevented?.

P. Coumel.

42. Can Diet Prevent Sudden Cardiac Death?.

M. de Lorgeril.


XII: Medical Therapy.

43. Mechanisms of Defibrillation.

N. Chattipakorn, R.E. Ideker.

44. Can Nonarrhythmic Drugs Prevent Sudden Cardiac Death?.

E. Aliot, C. de Chillou, I. Magnin-Poull, N. Sadoul.


XIII: Nonmedical Therapy.

45. Ventricular Tachycardia Antiarrhythmic Surgery: The Legacy.

G.M. Guiraudon G.J. Klein, C.M. Guiraudon.


XIV: Automatic Implantable Cardioverter-Defibrillators.

46. A Critical Appraisal of Implantable Cardioverter-Defibrillator/Drug Trials in the Secondary Prevention of Sudden Cardiac Death.

G.V. Naccarelli, D.L. Wolbrette, H.T. Patel, J.C. Luck.

47. Quality of Life in Patients with Implantable Cardioverter-Defibrillators.

C. Wolpert, W. Jung, S. Herwig, B. Luderitz.

48. Economic Aspects of Implantable Cardioverter-Defibrillator Therapy.

O.A. Obel, A.J. Camm.

49. Can We Learn From Ongoing Implantable Cardioverter-Defibrillator Trials?.

M. Fromer.

50. The Future: A Hybrid Therapy.

S. Saksena.



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