Fluorine in Medicinal Chemistry and Chemical Biology / Edition 1

Hardcover (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $190.69
Usually ships in 1-2 business days
(Save 22%)
Other sellers (Hardcover)
  • All (3) from $190.69   
  • New (2) from $198.78   
  • Used (1) from $190.69   

Overview

The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development.

Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include:

  • Discovery and development of fluorine containing drugs and drug candidates.
  • New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates.
  • Structural and chemical biology of fluorinated amino acids and peptides.
  • Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis.
  • Applications of 19F NMR spectroscopy in biomedical research.

An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action.

Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.

Read More Show Less

Product Details

  • ISBN-13: 9781405167208
  • Publisher: Wiley
  • Publication date: 4/20/2009
  • Edition number: 1
  • Pages: 640
  • Product dimensions: 6.80 (w) x 9.90 (h) x 1.60 (d)

Meet the Author

Professor Iwao Ojima is Distinguished Professor in the Department of Chemistry, and Director of the Institute of Chemical Biology & Drug Discovery, at the State University of New York at Stony Brook. He has published over 340 papers and reviews, more than 140 patents and patent applications, and edited 5 books, including Biomedical Frontiers of Fluorine Chemistry, published in the ACS Symposium Series in 1996.

Read More Show Less

Table of Contents

Introduction

Chapter 1 “Unique Properties of Fluorine and Their Relevance to Medicinal Chemistry and Chemical Biology” by Takashi Yamazaki, Takeo Taguchi and Iwao Ojima

Medicinal Chemistry

Chapter 2 “Fluorinated Prostanoids: Development of Tafluprost, a New Anti-glaucoma Agent” by Yasushi Matsumura

Chapter 3 “Fluorinated conformationally restricted glutamate analogs for CNS drug discovery and development” by Atsuro Nakazato

Chapter 4 “Fluorinated Inhibitors of Matrix Metalloproteinases” by Roberta Sinisi, Monika Jagodzinska, Gabriele Candiani, Florent Huguenot, Monica Sani, Alessandro Volonterio, Raffaella Maffezzoni and Matteo Zanda

Chapter 5 “Fluoro-Taxoid Anticancer Agents” by Antonella Pepe, Larisa Kuznetsova, Liang Sun and Iwao Ojima

Chapter 6 “Antimalarial Fluoroartemisinins: Increased Metabolic and Chemical Stability”by Jean-Pierre Bégué, Danièle Bonnet-Delpon

Chapter 7 “Synthesis and Biological Activity of Fluorinated Nucleosides” by Tokumi Maruyama, Masahiro Ikejiri, Kunisuke Izawa and Tomoyuki Onishi

Synthetic methods for medicinal chemistry and chemical biology

Chapter 8 “Synthesis of gem-Difluoromethylenated Nucleosides via gem-Difluoromethylene-Containing Building Blocks” by Wei-Dong Meng and Feng-Ling Qing

Chapter 9 “Recent Advances in the Syntheses of Fluorinated Amino Acids” by Kenji Uneyama

Chapter 10 “Fluorinated Moieties for Replacement of Amide and Peptide Bonds” by Takeo Taguchi and Hikaru Yanai

Chapter 11 “Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery” by David Armstrong, Matthew W. Cartwright, Emma L. Parks, Graham Pattison, Graham Sandford, Rachel Slater, John A. Christopher, David D. Miller, Paul W. Smith and Antonio Vong

Chapter 12 “gem-Difluorocyclopropanes as key building blocks for novel biologically active molecules” by Toshiyuki Itoh

Chapter 13 “Fluorous Mixture Synthesis (FMS) of Drug-Like Molecules and Enantiomers, Stereoisomers, and Analogs of Natural Products” by Wei Zhang

Chapter 14 “Fluorine-18 Radiopharmaceuticals” by Michael R. Kilbourn and Xia Shao


Applications of fluorinated amino acids and peptides to chemical biology and pharmacology

Chapter 15 “Application of Artificial Model Systems to Study the Interactions of Fluorinated Amino Acids within the Native Environment of Coiled Coil Proteins” by Mario Salwiczek, Toni Vagt and Beate Koksch

Chapter 16 “Fluorinated Amino Acids and Biomolecules in Protein Design and Chemical Biology” by He Meng, Ginevra A. Clark, and Krishna Kumar

Chapter 17 “Effects of Fluorination on the Bioorganic Properties of Methionine” by John F. Honek

Chapter 18 “Structure analysis of membrane-active peptides using 19F-labeled amino acids and solid state NMR” by Parvesh Wadhwani and Erik Strandberg

Chapter 19 “Metabolism of Fluorine-containing Drugs using in vivo Magnetic Resonance Spectroscopy” by Erika Schneider

Appendix

“FDA-Approved Active Pharmaceutical Ingredients Containing Fluorine” by Elizabeth Pollina-Cormier, Manisha Das, and Iwao Ojima

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)