Fluoroquinolone Antibiotics / Edition 1

Fluoroquinolone Antibiotics / Edition 1

by Allan R. Ronald
     
 

ISBN-10: 3764365919

ISBN-13: 9783764365912

Pub. Date: 04/01/2003

Publisher: Birkhauser Basel

The quinolones are making a significant contribution to patient care and have added a new dimension to antibacterial therapy. During the last decade, they became important agents for treating hospital-acquired infections. This volume covers their mechanisms of action, resistance mechanisms and epidemiology, pharmacokinetics, safety and clinical applications. Their

Overview

The quinolones are making a significant contribution to patient care and have added a new dimension to antibacterial therapy. During the last decade, they became important agents for treating hospital-acquired infections. This volume covers their mechanisms of action, resistance mechanisms and epidemiology, pharmacokinetics, safety and clinical applications. Their effectiveness for respiratory, urinary, sexually transmitted, skin, soft tissue, bone and joint infections, infections of the eyes, ears, nose and throat, and less common infections such as mycobacterial, Brucella and others are reviewed. Also described is their use in pediatric, oncology and immunocompromised patients. The quinolone story continues to be intriguing with exciting future implications.This monograph is an important comprehensive review and update for researchers and clinicians in pharmacology, clinical medicine, molecular and cell biology, epidemiology and the pharmaceutical industry.

Product Details

ISBN-13:
9783764365912
Publisher:
Birkhauser Basel
Publication date:
04/01/2003
Series:
Milestones in Drug Therapy Series
Edition description:
2003
Pages:
261
Product dimensions:
6.10(w) x 9.25(h) x 0.36(d)

Table of Contents

The history of quinolones.- Structure-activity relationships of quinolones.- Epidemiology and mechanisms of resistance.- Improved safety profile of newer fluoroquinolones.- Pharmacokinetics and pharmacodynamics (PK/PD) of fluoro-quinolones: tools for combating bacteria and preventing resistance.- Fluoroquinolones in urinary tract infection.- The quinolones and sexually transmitted infections.- Gastrointestinal and intraabdominal infections.- The quinolones in otitis media and upper respiratory infections.- Quinolones in pneumonia.- Fluoroquinolones for the treatment of respiratory tractinfections other than pneumonia.- Quinolones for the treatment of skin, soft tissue, bone andprosthetic joint infections.- The role of fluoroquinolones in the therapy and prophylaxisof neutropenic patients with cancer.- Less usual indications: Mycobacterial, Brucella, Yersinia,Francisella and other infections.- The quinolones: future prospects.

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