Fluoroquinolone Antibiotics / Edition 1

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The quinolones are making a significant contribution to patient care and have added a new dimension to antibacterial therapy. During the last decade, they became important agents for treating hospital-acquired infections. This volume covers their mechanisms of action, resistance mechanisms and epidemiology, pharmacokinetics, safety and clinical applications. Their effectiveness for respiratory, urinary, sexually transmitted, skin, soft tissue, bone and joint infections, infections of the eyes, ears, nose and throat, and less common infections such as mycobacterial, Brucella and others are reviewed. Also described is their use in pediatric, oncology and immunocompromised patients. The quinolone story continues to be intriguing with exciting future implications.This monograph is an important comprehensive review and update for researchers and clinicians in pharmacology, clinical medicine, molecular and cell biology, epidemiology and the pharmaceutical industry.

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Product Details

  • ISBN-13: 9783764365912
  • Publisher: Birkhauser Basel
  • Publication date: 4/1/2003
  • Series: Milestones in Drug Therapy Series
  • Edition description: 2003
  • Edition number: 1
  • Pages: 261
  • Product dimensions: 0.69 (w) x 6.14 (h) x 9.21 (d)

Table of Contents

List of contributors
The history of quinolones 1
Structure-activity relationships of quinolones 11
Epidemiology and mechanisms of resistance 49
Improved safety profile of newer fluoroquinolones 73
Pharmacokinetics and pharmacodynamics (PK/PD) of fluoroquinolones: tools for combating bacteria and preventing resistance 87
Fluoroquinolones in urinary tract infection 107
The quinolones and sexually transmitted infections 121
Gastrointestinal and intraabdominal infections 137
The quinolones in otitis media and upper respiratory infections 167
Quinolones in pneumonia 177
Fluoroquinolones for the treatment of respiratory tract infections other than pneumonia 189
Quinolones for the treatment of skin, soft tissue, bone and prosthetic joint infections 205
The role of fluoroquinolones in the therapy and prophylaxis of neutropenic patients with cancer 219
Less usual indications: Mycobacterial, Brucella, Yersinia, Francisella and other infections 239
The quinolones: future prospects 251
Index 255
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