Formulation of Fast Dispersible Tablet of Fexofenadine Hcl

Formulation of Fast Dispersible Tablet of Fexofenadine Hcl

by Arpitkumar Shah, Mukesh Patel, Natvarlal M. Patel
     
 

The purpose of this research was to formulate tasteless complexes of Fexofenadine Hydrochloride with Kyron-134 and to formulate tasteless complex into fast-Dispersible tablets (FDT) for the treatment of allergic rhinitis & chronic idiopathic urticaria. Drug release from FDT in salivary pH was insufficient to impart bitter taste. Complete drug release was observed at…  See more details below

Overview

The purpose of this research was to formulate tasteless complexes of Fexofenadine Hydrochloride with Kyron-134 and to formulate tasteless complex into fast-Dispersible tablets (FDT) for the treatment of allergic rhinitis & chronic idiopathic urticaria. Drug release from FDT in salivary pH was insufficient to impart bitter taste. Complete drug release was observed at gastric pH. The studies indicate that the formulation was taste masked drug can be formulated in to FDT with view to enhance patient compliance & to obtain faster onset action of the drug which would be advantageous in comparison to the currently available conventional forms. Formulations D-5 was found to be palatable with in vitro disintegration time of 20 s Dissolution studies showed complete release of D-5 within 30 min.

Product Details

ISBN-13:
9783659156489
Publisher:
AV Akademikerverlag GmbH & Co. KG.
Publication date:
06/27/2012
Pages:
152
Product dimensions:
6.00(w) x 9.00(h) x 0.35(d)

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