Formulation Strategies For Dissolution Enhancement Of Insoluble Drugs

Formulation Strategies For Dissolution Enhancement Of Insoluble Drugs

by Rajnikant Patel, Madhabhai Patel, Natvarlal M. Patel
     
 

Dissolution is important parameter to achieve desired concentration of drug in systemic circulation for elicit pharmacological response. The formulation of poorly soluble drugs has been the subjects of much research, as approximately 40% of new chemical entities develop in pharmaceutical industries are insoluble in nature. In the present investigation drugs which are… See more details below

Overview

Dissolution is important parameter to achieve desired concentration of drug in systemic circulation for elicit pharmacological response. The formulation of poorly soluble drugs has been the subjects of much research, as approximately 40% of new chemical entities develop in pharmaceutical industries are insoluble in nature. In the present investigation drugs which are practically insoluble in gastric fluid and having high permeability through stomach were selected. The rational for selecting such type was "Drugs which are only permeable through stomach but due to its solubility limitation in gastric fluid they can not enter in to systemic circulation, further more gastric empting time is ranging form 30 mins to 2 hrs after this time drugs enter in to small intestine where they can soluble but can not permeable through its membrane due to its permeation limitation". To improve dissolution of such drugs in stomach are challenging and rational. Attempts were made to prepare formulations which would dissolved completely within 30 minutes or retain in stomach for more than 2 hrs if drugs can not soluble in 2 hrs even after addition of solubilising enhancing excipients.

Read More

Product Details

ISBN-13:
9783844310696
Publisher:
AV Akademikerverlag GmbH & Co. KG.
Publication date:
03/10/2011
Pages:
180
Product dimensions:
6.00(w) x 9.00(h) x 0.41(d)

Customer Reviews

Average Review:

Write a Review

and post it to your social network

     

Most Helpful Customer Reviews

See all customer reviews >